Current vacancies

Overview of the all job opportunities within Sanger.

Advanced Research Assistant

Salary range £26,960 - £32,622 depending on experience plus excellent benefits

Fixed Term contract for 1 or 2 years.

We are seeking to appoint a highly motivated individual to provide laboratory research support for the Soranzo team (http://www.sanger.ac.uk/research/faculty/nsoranzo/) at the Wellcome Sanger Institute.

The group's primary research interest is to investigate the effect of genetic variation on human phenotype, including quantitative organismal and molecular traits, combining statistical analyses and functional genomics approaches. We have recently revealed thousands of loci at high resolution for common and rare genetic variants which affect human blood cell traits (Astle et al Cell 2016). Through integration with large scale molecular phenotyping, including characterising layers of transcription and epigenetic states, we have begun to resolve the molecular mechanisms in which these variants act.

We are now looking to recruit an Advanced Research Assistant to work on new and exciting projects further elucidating these observations. The primary goal of this work will be to apply large scale genetic screens to test the functional consequences of common and rare genetic variants implicated in haematopoietic cell development and function.

Your primary responsibility will be to contribute to the team’s research by supporting laboratory projects involving cell culture and genetic engineering techniques. This project offers the opportunity to work in a multi-disciplinary team building upon recently published and diverse data sets with the potential to apply various molecular biology and genome editing technology to answer key questions affecting human biology. You will work in close collaboration with computational scientists and have significant opportunities to work in collaboration with other groups at the Institute.

The post will be for one year initially with possible opportunity to extend to two years.

Reference:83488


Advanced Research Assistant

Open Targets

Salary range £26,960 - £32,622 depending on experience plus excellent benefits

Fixed term for 3 years.

A position is now available for a highly motivated Advanced Research Assistant to join the research group of Dr. Ana Cvejic, Dr Peter Campbell and Open Targets partners at the Wellcome Sanger Institute.

Open Targets aims to provide evidence on the biological validity of therapeutic targets and provide an initial assessment of the likely effectiveness of pharmacological intervention on these targets, using genome-scale experiments and analysis. This pioneering public-private partnership between Sanofi, Celgene, EMBL-EBI, GlaxoSmithKline, Takeda, and the Wellcome Sanger Institute, aims to provide a R&D framework that applies to all aspects of human disease, and to share its data openly with the scientific community (http://www.opentargets.org).

We are seeking an enthusiastic Advanced Research Assistant to carry out both routine and more bespoke laboratory protocols and procedures. The research focuses on the regulation of haematopoiesis in homeostasis and disease.  You will work as part of the team to provide laboratory support for the lab members. You will be working with a number of molecular biology techniques, in particular single cell transcriptomics, epigenetics and in vitro cell culture. You will be able to use your skills and experience to troubleshoot and innovate where required. Excellent verbal and email communication is essential to keep both the team and senior staff fully appraised of progress.

 

Reference:83467


Animal Technician - Full/part time and flexible working opportunities available

Salary range £20,453 to £24,748 - (Additional pay through overtime, weekend and bank holiday working)

Full time, part time and flexible working opportunities available 

Do you want to care for animals? 

Looking for a new opportunity?

About us:

We have a state of the art animal facility providing a controlled environment for the mice, and fish housed within it using IVC technology.

Our state of the art facility provides

  • a dedicated animal barrier,
  • germ free and containment giving provision for the housing and utilisation of model organisms in research in breeding colonies and experimental groups. 

Daily task and responsibilities would include:

  • providing food and water for the animals and organising special diets if needed
  • carrying out regular observations and health checks
  • making sure that animals are clean, comfortable and behaving as expected
  • keeping up high levels of hygiene for each animal
  • monitoring heating, lighting and humidity
  • monitoring the weight and growth of animals
  • maintaining high standards of cleanliness throughout the animal facility
  • keeping accurate records and inputting data onto computer systems.

As part of the team you will be required to participate in weekend/public holiday rota (1 weekend in 3) to ensure we are staffed and maintained at all times. You will receive an enhanced over time rate during these periods of work. 

Training and beyond:

We will provide you with all the appropriate training for you to fulfil your role and offer you a career pathway so you can continue to progress and learn new skills with us! 

Once you have the experience and have completed the training required, you could also be involved in setting up scientific studies and breeding animals. You may also train and mentor other Animal Technicians and trainees.

What we can offer:

Our employees have access to a comprehensive range of benefits and facilities including:

  • Defined Contribution Pension Scheme and Life Assurance
  • Group Income Protection
  • Private Health Insurance
  • 25 days annual leave, increasing by one day a year to a maximum of 30
  • Family friendly environment including options for flexible and part-time working, a childcare voucher scheme and Campus Nursery
  • Two days paid Employee Volunteering Leave a year
  • Employee Discount Scheme
  • Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities
  • Active Campus Sports and Social Club
  • Free Campus Bus Service

Reference:83429


Bioinformatics Apprentice - PaM

Salary £17,489 per annum plus benefits 

4 year apprenticeship

We have an exciting opportunity for someone to join the Parasites and Microbes research programme as an Apprentice Bioinformatician, whilst working towards gaining a BSc (Hons) Bioinformatics Degree at Anglia Ruskin University CLICK HERE

Watch this video to learn about what Bioinformatics is and how the Degree apprenticeship works CLICK HERE

We encourage individuals who are enthusiastic, eager to learn, willing, and able to work in a team environment.

You will be involved in multiple activities, run as a series of placements of up to a year, across several research teams that use genomics as a core part of basic and applied infectious-disease research. You will work collaboratively to support ongoing projects by analysing data, developing analysis pipelines and interfaces. 

This is a developmental role to encourage new talent in the area of Bioinformatics. Following training complementary to your apprenticeships degree you will: 

  • Work with large sets of genome or transcriptome data.
  • Develop and maintain Bioinformatics analysis programs and pipelines
  • Use modern Cloud infrastructure to run pipelines
  • Interact with wet-lab and dry-lab scientists 

During your apprenticeship we can offer you: 

  • A senior team member dedicated as your mentor
  • A permanent publically available portfolio of your coding and development
  • Opportunity to publish results
  • Mentoring program to explore your long-term opportunities
  • A comfortable working environment with a first name culture, informal dress code, a company social calendar and modern offices set to the 55 acre grounds of Hinxton Hall and associated wetland reserve.

Application enquiries should be directed to apprenticeships@sanger.ac.uk

Reference:83468


Bioinformatics Apprentice - IT

Salary £17,489 per annum plus benefits 

4 year apprenticeship

We are looking for enthusiastic and passionate individual to join the Genome Reference Informatics Team as an Apprentice whilst working towards gaining a fully funded BSc (Hons) Bioinformatics Degree Apprenticeship at Anglia Ruskin University CLICK HERE

Watch this video to learn about what Bioinformatics is and how the Degree apprenticeship works CLICK HERE

You will have the opportunity to develop in the area of IT and Bioinformatics, gaining valuable skills whilst making an important contribution to the institute and its Darwin Tree of Life Project which will decipher the genetic code of all life in the British Isles. You will be given the appropriate training and learn from our experienced team where you will go on to:

  • Help generating genome assemblies for the Darwin Tree of Life Project
  • Manage and assess big data for our genome sequencing projects
  • Assist in the development and running of pipelines and processes to further improve assemblies
  • Interact with our on-site scientists and informaticians as they tackle tomorrow’s scientific challenges

About us: 

Our team is responsible for: Assembly generation, assessment and improvement as well as data management and assisting collaborators in the interpretation of genomic data. You will be involved in all key activities, with the intention to develop and take on more responsibilities as your knowledge and skills grow.

During your apprenticeship we can offer you:

  • A mentor and membership to our mentoring program to explore your long-term opportunities
  • A permanent publicly available portfolio of your coding and development 
  • A comfortable working environment with a first name culture, informal dress code, and company social calendar 
  • The opportunity to work with cutting edge datasets in the genomics world and conduct scientific analyses at very large scale
  • Access to talks from high profile scientific speakers 
  • Exposure to the inner workings of a world-renowned genome research institute 

Application enquiries should be directed to apprenticeships@sanger.ac.uk

Reference:83463


Computational Biologist/Bioinformatician

Open Targets

Salary range: £36,737-£44,451 per annum depending on experience plus excellent benefits.

Fixed Term Contract for 3 Years.

Open Targets has recently launched Open Targets Genetics (https://genetics.opentargets.org), a portal that aggregates large scale GWAS data with functional genomics data to identify potential drug targets at disease-associated loci.

Computational Biologist/Bioinformatician role funded by Open Targets, is available at the Wellcome Sanger Institute in a new team under the leadership of Dr. Maya Ghoussaini. This is an exciting opportunity for you to participate in the enhancement of the existing Open Targets Genetics Portal through the development of new functionality and features.

You will actively engage in the integration of new eQTL datasets and tissue-specific genomic datasets.

You will have the opportunity to work across a range of analysis such as:

  • Integrate genetic and cell-specific genomic data to identify and validate casual links between targets and diseases and improve the Genetics Portal
  • Perform association analysis on UK Biobank data with a particular focus on therapeutic areas important for Open Targets
  • Work together with other members of the Open Targets team on statistical genetics analysis for large scale sequence analysis

In this role, you will develop and apply computational pipelines to elucidate causal mechanisms through integrative analyses of data from GWAS, eQTL/pQTL, chromatin interactions and conformation, biobanks, and other related sources to identify and prioritise drug targets

 You will have the opportunity to interact with active computational and experimental research teams using cutting edge genomic techniques. 

Reference:83434


Computational Postdoctoral Fellow - Cancer Drug Combinations

Open Targets

 

Salary range £31,897 - £39,240 (dependent on experience) plus excellent benefits

Fixed Term for 3 Years

The Garnett lab is seeking a computational postdoctoral scientist to use CRISPR-Cas9 screening to identify combination targets for cancer.

Many cancer patients have tumours with resistance to standard of care therapy or have a

molecular context that is not addressed by current treatments. Combination therapies aimed at inhibiting multiple targets or cancer pathways can combat resistance and exploit new actionable dependencies in defined genetic contexts.  The aim of this study is to exploit the power of large-scale CRISPR screening in cancer cell lines to identify and investigate new target combination for cancer.

A postdoctoral position is available in the Garnett lab as part of a collaborative research team. The position involves development of analytical and statistical approaches to model gene-gene interactions using large-scale CRISPR screening datasets, and combining these results with genomic data, transcriptomic and proteomic datasets.

This project forms part of the Open Targets collaboration, a private-public partnership between academia and industry, including the Sanger Institute, the European Bioinformatics Institute (EBI: Petsalaki lab), European Molecular Biology Laboratory (EMBL: Zaugg lab) and pharmaceutical companies as part of the Open Targets community.

You should have a PhD in computer science, cancer bioinformatics or related discipline, with experience working with large-scale genomic and functional genomic datasets.

You will be team players, have excellent organizational skills, and strong verbal and written communications skills, as well as a proven track record of productivity. Postdoctoral fellows are typically in their first or second postdoctoral position as part of a period of early career research training. The position is initially for a 3-year fixed term.   

Further details of the Garnett lab (https://www.sanger.ac.uk/science/groups/garnett-group) and Open Targets (https://www.opentargets.org/) are available at the provided links.

Reference:83477


Conference & Events Office Administrator

Connecting Science

Salary range £19,514 to £23,612 per annum depending on experience, plus excellent benefits

Fixed Term contract for 2 years.

We are looking for an enthusiastic and experienced Administrator to support our busy Advanced Courses and Scientific Conference Programme at the Wellcome Genome Campus. 

Working within the Scientific Conference’s event management team you will support the Conference & Events Manager and the Conference & Events Organisers team with their day to day administration. The workload will be varied and include setting up conference calls, processing speaker expense claim forms, attending meetings and minute taking, managing the group e-mail account and updating and maintaining databases, websites and spreadsheets. 

To succeed in the role of Conference & Events Office Administrator you will be methodical and well organised, you will be able to work well within a small team and demonstrate excellent communication skills. You will need to be able to work flexibly, meet deadlines and help work on a number of Conference & Events projects which will be at different stages simultaneously.

Reference:83425


International Fellows Programme

The opportunity

We are seeking to appoint International Fellows to contribute to the Institute’s scientific portfolio.  Fellows should be early career stage scientists with existing faculty positions in a low or middle income country. Applications from senior scientists whose proposals are tightly aligned with the Institute’s strategic direction will also be considered.

The Institute is an internationally renowned genomic research centre with nearly 35 core faculty teams and 1,100 employees, based south of Cambridge. Our mission is to use genomic data to advance understanding of the biology of humans and pathogens in order to improve human health. With core funding and state-of-the-art platforms in sequencing, model organisms, cellular genetics and information technology, we enable our researchers to concentrate on biological questions across a diverse range of genomic and genetic science, in both independent studies and large-scale collaborations. The result is a unique, vibrant and interactive research environment with synergies and cross-fertilisation of ideas across and between our research programmes. 

We welcome applications from candidates whose research interests complement one of our four research programmes, wish to work closely with Sanger faculty and are able to bring in new capabilities and new ideas. Applications from individuals who have a different scientific focus within the broad field of genomics are also welcome. 

The successful candidates will initially be appointed for two years, with the potential for renewal for an additional two years upon successful review. Fellows will be allocated a yearly budget that can be used for research costs, as a stipend to supplement salary costs at their home institution, as well as travel costs.

To maximise the impact of our International Fellows programme, Fellows are expected to spend several months at the Wellcome Sanger Institute during their appointment, where they will benefit from access to the Institute’s fantastic research community and infrastructure. However, we understand this type of commitment could cause disruption to work and home-life and are very open to discussion surrounding flexibility with individual’s circumstances (please see below).

About you

Ideal candidates will have typically completed a PhD or MD within the past 10 years as well as having at least three years experience in a post-doctoral or clinical setting.  Candidates with more experience will need to demonstrate a well-defined research agenda that is relevant to the Wellcome Sanger Institute and impactful to their home Institution.  All candidates need to be associated with an institute of higher learning, research centre, or hospital within a low or middle income country.

About us

The Institute is located on the stunning Wellcome Genome Campus. This growing and dynamic site is the UK hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre, and Genomics England Limited’s 100,000 Genomes Sequencing Centre. The Campus is also home to the Wellcome Conference Centre and the Wellcome Genome Campus Connecting Science. Connecting Science inspires new thinking, sparks conversation and supports learning by drawing on the ground-breaking research taking place on the Campus.

What else do I need to know?

We have a dedicated Visa and Immigration adviser to provide expert, reliable advice on a range of immigration queries that support the global outlook and collaborative nature of the Institute. We are able to advise and support initial visa applications. Visa information will be discussed in more depth with successful applicants.

Reference:83421


Legal Counsel (part time and flexi working considered)

Competitive salary plus benefits 

Part time and flexible working considered equally alongside full time applications.

The Wellcome Sanger Institute is one of the premier centres of genomic discovery and understanding in the world. Through big, bold, exploratory research it continually seeks new ways to unlock, understand and harness the wealth of information stored within genomes, in order to improve health and life on earth.  As a result, it has been instrumental in some of the most significant initiatives and projects in genomics over the last 25 years. The Wellcome Sanger Institute leads ambitious collaborations across the globe to provide the foundations for further research and transformative healthcare innovations. Its success is founded on the expertise and knowledge of its people and the Institute seeks to share its discoveries and techniques with the next generation of genomics scientists and researchers worldwide.

We currently have two opportunities to join our small, one site based team reporting into the General Counsel. You'll have a minimum of 6 years PQE, but more experienced candidates are encouraged to apply. 

As Legal Counsel for Wellcome Sanger Institute, you’ll:

  • Support our technology transfer team, research programmes and management operations teams, including advising them on a wide range of activities;
  • Draft and negotiate a broad range of research, collaboration and similar agreements; and
  • Work closely with our Faculty and Board of Management advising them on complex issues, implications, risks and courses of action.

Reference:83491


Postdoctoral Fellow - Bacterial Evolutionary Biology

Salary in the region of £31,897 - £39,986 (dependent on experience) plus excellent benefits

Fixed term for 3 years

We are seeking a talented, motivated scientist with a strong interest in, and experience of, analyzing genomes and large genomic datasets to gain insights into the patterns and drivers of pathogen evolution. Ideally you would have biological or mathematical/statistics background with a demonstrated interest in developing bioinformatic skills or have proven track record of applying existing skills toward the analysis of complex genomic datasets. 

The position you are applying for falls within the Bacterial Genomics and Evolution faculty team, under the leadership of Professor Nick Thomson. We use genomic approaches to explore questions of basic science relating to the evolution and spread of bacterial pathogens in both humans and animals. We have established, over many years, strong collaborations with groups working on infectious diseases in local as well as national public health settings, NGO’s and leading research institutes around the world, providing access to people, resources and incredible datasets. We have a specialist interest in the evolution and spread of diarrhoeal disease (both the pathogen[s], their host[s] and the role of the microbiota) and tropical diseases. The team has a broad range of lab and informatics experience, and works collaboratively to analyse complex datasets with a history of developing novel informatics and lab-based approaches for accessing genomic and transcriptomic data.  

To help you see the type of work we have been doing, here is a selection of the team’s most recent publications. 

Tropical and diarrhoeal diseases:

Methods lab and in silico:

Antimicrobial resistance: 

In addition, these are important papers from other groups chosen to give you a sense of the team’s broader interests and areas/themes that they may wish to explore. 

If you wish to highlight a possible area of interest based on any of the papers above for further discussion, if shortlisted for an interview, please do highlight this in your application.  

This position would place you within a Faculty team within the Parasites and Microbes Programme, all set within a world leading genomics institute. You would be working closely with informaticians, wet-lab biologists, Postdoctoral Fellows and PhD students within the group and across this programme. You will be required to coordinate analysis of multiple project datasets and identify and establish new collaborations and projects, as well as to form part of an integrated team. The candidate will have substantial support and opportunities to broaden their skill-set and further their career.

Reference:83458


Postdoctoral Fellow - Cancer Drug Combinations

Open Targets

 

Salary range £31,897 - £39,240 (dependent on experience) plus excellent benefits

Fixed Term for 3 Years

The Garnett lab is seeking a postdoctoral scientist to use CRISPR-Cas9 screening to identify combination targets for cancer.

Many cancer patients have tumours with resistance to standard of care therapy or have a

molecular context that is not addressed by current treatments. Combination therapies aimed at inhibiting multiple targets or cancer pathways can combat resistance and exploit new actionable dependencies in defined genetic contexts.  The aim of this study is to exploit the power of large-scale CRISPR screening in cancer cell lines to identify and investigate new target combination for cancer.

A postdoctoral position is available in the Garnett lab as part of a collaborative research team. You will develop dual-knockout CRISPR-based screening approaches and lead efforts to experimentally evaluate combination targets.

This project forms part of the Open Targets collaboration, a private-public partnership between academia and industry, including the Sanger Institute, the European Bioinformatics Institute (EBI: Petsalaki lab), European Molecular Biology Laboratory (EMBL: Zaugg lab) and pharmaceutical companies as part of the Open Targets community.

You  have experience using CRISPR and CRISPR-based screening methods, strong molecular biology and tissue culture skills, and have a knowledge of cancer biology and therapeutics.

You will be team players, have excellent organizational skills, and strong verbal and written communications skills, as well as a proven track record of productivity. Postdoctoral fellows are typically in their first or second postdoctoral position as part of a period of early career research training. The position is initially for a 3-year fixed term.   

Further details of the Garnett lab (https://www.sanger.ac.uk/science/groups/garnett-group) and Open Targets (https://www.opentargets.org/) are available at the provided links.

Reference:83478


Postdoctoral Fellow - Computational

Open Targets

Salary range £31,897 - £39,240 (dependent on experience) plus excellent benefits

Fixed term for 3 years

A postdoctoral position is available at the Wellcome Sanger Institute under the leadership of Dr Ana Cvejic and Dr Peter Campbell as part of the Open Targets project.

Open Targets aims to provide evidence on the biological validity of therapeutic targets and provide an initial assessment of the likely effectiveness of pharmacological intervention on these targets, using genome-scale experiments and analysis. This pioneering public-private partnership between Sanofi, Celgene, EMBL-EBI, GlaxoSmithKline, Takeda, and the Wellcome Sanger Institute, aims to provide a R&D framework that applies to all aspects of human disease, and to share its data openly with the scientific community (http://www.opentargets.org).

The project will combine state-of-the-art single-cell experimental data generation with computational analysis using novel methods to reveal the full spectrum of transcriptional and epigenetic changes that are associated with myeloid progenitors’ migration and differentiation at the tumour sites.

You will have a PhD in Bioinformatics, Computational Biology, Biostatistics or in a related quantitative field (e.g. Mathematics, Physics, Statistics). You will be passionate about science and excited to learn and improve skills in an outstanding research environment. You will be part of a multidisciplinary team, seeking and maintaining appropriate collaborations. You will also be expected to drive forward the project, working closely with biologists, clinicians and bioinformaticians within and outside the group to accomplish scientific objectives.

Reference:83461


Postdoctoral Fellow - Experimental Data Generation

Open Targets

Salary range £31,897 - £39,240 (dependent on experience) plus excellent benefits

Fixed term for 3 years

A position is now available for a highly motivated Postdoctoral Fellow to join the research group of Dr. Ana Cvejic, Dr Peter Campbell and Open Targets partners at the Wellcome Sanger Institute (WSI). 

Open Targets aims to provide evidence on the biological validity of therapeutic targets and provide an initial assessment of the likely effectiveness of pharmacological intervention on these targets, using genome-scale experiments and analysis. This pioneering public-private partnership between Sanofi, Celgene, EMBL-EBI, GlaxoSmithKline, Takeda, and the Wellcome Sanger Institute, aims to provide a R&D framework that applies to all aspects of human disease, and to share its data openly with the scientific community (http://www.opentargets.org).

The project will combine state-of-the-art single-cell experimental data generation with computational analysis using novel methods to reveal the full spectrum of transcriptional and epigenetic changes that are associated with myeloid progenitors’ migration and differentiation at the tumour sites.

You will have a PhD with significant experience in molecular and cell biology. Experience in CRISPR screening will be highly desirable. Knowledge or interest in the field of haematology, cancer biology and inflammation would be highly advantageous. You will be able to demonstrate independent, critical thinking, will be passionate about science, and keen to learn and improve skills in an outstanding research environment.

Reference:83465


Postdoctoral Fellow - Functional Genomics

Salary range: £31,897-£39,986 per annum depending on experience plus excellent benefits.

Fixed Term Contract for 3 Years.

Applications are invited for a 3-year Postdoctoral Fellowship within the Genomics of Inflammation and Immunity group at the Wellcome Sanger Institute (WSI), headed by Dr. Carl Anderson (www.andersonlab.info). Our group uses large-scale genetic and genomic data to understand the biological basis of inflammatory bowel disease (IBD) risk and progression. The ultimate goal of our IBD research is to identify new drug targets for the disease, and ascertain which individuals should be prescribed a given drug.

We have been awarded funding from the Crohn’s Colitis Foundation (CCF) to generate single-cell transcriptomic data from intestinal biopsies obtained from 160 IBD patients undergoing colonoscopy. All individuals will also be genotyped, with the goal of combining these datasets to map eQTLs across the more than forty different cell-types in the inflamed gut. The results from these analyses will then be combined with our detailed maps of IBD risk loci (and other gastrointestinal diseases) to identify genes that are dysregulated to bring about disease. The ultimate goal of the research is thus to improve our basic knowledge of IBD pathogenesis and identify novel candidate drug targets for treating disease.

You will use your established expertise in single-cell genomics and/or QTL mapping to lead the analysis and ensure that the project delivers on its ambitious goals. You will take intellectual ownership of the project and think broadly about questions that can be addressed using the data. You will collaborate closely with other members of the Anderson Lab working on a similar project to build a single-cell derived map of gut eQTLs from biopsies ascertained from 300 healthy individuals. As such, this project will suit a self-motivated individual with good communication skills who is looking to make a personal contribution to genomic research.

Reference:83482


Postdoctoral Fellow - Single Cell Genomics

 Open Targets

Salary range: £31,897-£39,986 per annum depending on experience plus excellent benefits.

Fixed Term Contract for 3 Years.

Applications are invited for a 3-year Postdoctoral Fellowship within the Genomics of Inflammation and Immunity group at the Wellcome Sanger Institute (WSI), headed by Dr. Carl Anderson (www.andersonlab.info). Our group uses large-scale genetic and genomic data to understand the biological basis of inflammatory bowel disease (IBD) risk and progression. The ultimate goal of our IBD research is to identify new drug targets for the disease, and ascertain which individuals should be prescribed a given drug.

The project will generate single-cell transcriptomic data from intestinal biopsies obtained from 300 healthy individuals undergoing colonoscopy. All individuals will also be genotyped, with the goal of combining these datasets to map eQTLs across the more than forty different cell-types in the gut. The results from these analyses will then be combined with our detailed maps of IBD risk loci (and other gastrointestinal diseases) to identify genes that are dysregulated to bring about disease. The ultimate goal of the research is thus to improve our basic knowledge of IBD pathogenesis and identify novel candidate drug targets for treating disease.

This project forms part of the Open Targets collaboration (www.opentargets.org/), a public-private initiative between the Wellcome Sanger Institute (WSI), EMBL-EBI, GlaxoSmithKline (GSK), Biogen, Celgene, Takeda and Sanofi to combine large-scale genomic experiments with statistical and computational methods to identify and validate the causal links between targets, pathways and diseases. As a postdoctoral fellow working on this project, you will also benefit from close interactions with collaborating scientists from Open Targets pharmaceutical partners.

Based at the WSI, you will use your established expertise in single-cell genomics and/or QTL mapping to lead the analysis and ensure that the project delivers on its ambitious goals. You will take intellectual ownership of the project and think broadly about questions that can be addressed using the data. You will collaborate closely with other members of the Anderson Lab working on a similar project to build a single-cell derived map of gut eQTLs from biopsies ascertained from Crohn’s disease patients with active inflammation. As such, this project will suit a self-motivated individual with good communication skills who is looking to make a personal contribution to genomic research at the interface of academia and the pharmaceutical industry.

Reference:83472


Postdoctoral Fellow - Tumour Cell Immune Response CRISPR

Open Targets

Salary range £31,897 - £39,240 (dependent on experience) plus excellent benefits

Fixed Term for 3 Years

The Garnett lab is seeking a postdoctoral scientist to develop CRISPR base-editing screens to investigate tumour cell mediators of immune signalling and response to immunotherapy. 

Immunotherapies against PD1 and CTLA-4 are effective for the treatment of multiple tumour types. However, immune checkpoint blockade is not effective for all cancers or molecular subtypes, and the range and duration of clinical responses remains poorly understood. The aim of this project is to develop CRISPR base-editing screens in cancer cells to characterize regulation of tumour cell mediated immune signaling to understand mechanisms of resistance to checkpoint therapies. 

You will work as part of multidisciplinary and collaborative team. The project forms part of the Open Targets collaboration, a private-public partnership between academia and industry, including the Sanger Institute, the Netherlands Cancer Institute (PI: Dr. Emile Voest, MD PhD), and pharmaceutical companies as part of the Open Targets community.

You will have a background in immunology and cancer biology, an in-depth knowledge and experience of CRISPR-based screening methods, and strong molecular biology skills. You should be a team player, have excellent organizational skills, and strong verbal and written communications skills, as well as a proven track record of productivity. Postdoctoral fellows are typically in their first or second postdoctoral position as part of a period of early career research training. The position is initially for a 3-year fixed term.  

Further details of the Garnett lab (https://www.sanger.ac.uk/science/groups/garnett-group), Sanger Institute CRISPR R&D team (https://www.sanger.ac.uk/science/groups/gene-editing-and-cellular-research-and-development), (Voest lab (https://www.nki.nl/divisions/molecular-oncology-immunology/voest-e-group/) and Open Targets (https://www.opentargets.org/) are available at the provided links.

Reference:83479


Principal Animal Technician- Full/part time and flexible working available

Salary range £27,030 to £32,707 (Additional pay through overtime, weekend and bank holiday working)

We have part time, full time and flexible working opportunities

Do you want to care for animals? 

Looking for a new opportunity?

You will be responsible for the supervision and mentorship of a small team of technicians and the co-ordination of technical procedures in a specific area. Promoting and maintaining husbandry and welfare care for the animals within a defined area. You will also be expected to tackle various projects and to drive the implementation of standards and initiatives within your allocated area in support of the RSF managers.

About us:

We have a state of the art animal facility providing a controlled environment for the mice, and fish housed within it using IVC technology.

Our state of the art facility provides

  • a dedicated animal barrier,
  • germ free and containment giving provision for the housing and utilisation of model organisms in research in breeding colonies and experimental groups. 

As part of the team you will be required to participate in weekend/public holiday rota (1 weekend in 3) to ensure we are staffed and maintained at all times. You will receive an enhanced over time rate during these periods of work. 

What we can offer:

Our employees have access to a comprehensive range of benefits and facilities including:

  • Defined Contribution Pension Scheme and Life Assurance
  • Group Income Protection
  • Private Health Insurance
  • 25 days annual leave, increasing by one day a year to a maximum of 30
  • Family friendly environment including options for flexible and part-time working, a childcare voucher scheme and Campus Nursery
  • Two days paid Employee Volunteering Leave a year
  • Employee Discount Scheme
  • Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities
  • Active Campus Sports and Social Club
  • Free Campus Bus Service

Reference:83431


Research Administrator - Cellular Genetics

Salary in the region of £35,998 - £43,558 (dependent on experience) plus excellent benefits

Permanent/ Open Contract

The Wellcome Sanger Institute conducts cutting edge genomic research on an unprecedented scale and our administration team plays a vital role in enabling and supporting our science. The Cellular Genetics Programme is currently looking for a dynamic, ambitious, and skilled Research Administrator to support the Programme, and join our pioneering organisation.

Providing dedicated support to the Faculty Teams within the Cellular Genetics Programme, our Research Administrators need to take a collaborative approach to their work. Preferable candidates will hold a science degree and will have proven experience of working within a research environment. We are looking for individuals who can provide an efficient administrative service and facilitate effective communication between the Programme, key internal stakeholders and external partners. Strong project management skills, as well as recent experience of handling budgets and producing high quality grant applications, reports and briefing materials will be advantageous. A good understanding of the governance and regulation of the use of human samples is essential as many of our projects use human material and contribute data to the the Human Cell Atlas. 

If you are looking for an exciting opportunity to provide administrative support to amazing scientific research then we welcome your application. You'd be joining a tight-knit team within an Administration Network that promotes personal and professional development, thus giving the successful candidate the chance to grow within the role and build their potential.

Reference:83490


Research Administrator - Tree of Life

Salary in the region of £35,998 - £43,558 (dependent on experience) plus excellent benefits

Fixed term for 3 years

An exciting new opportunity has arisen for a dynamic, ambitious and skilled Research Administrator to assist and support the Programme Manager and Faculty members with the establishment and delivery of the Darwin Tree of Life Project which will decipher the genetic code of all life in the British Isles. The role will be making an important contribution to the Wellcome Sanger Institute on the Wellcome Genome Campus.   

Providing dedicated support to the Programme lead and their Faculty Teams within the Tree of Life Programme, our Research Administrator need to take a collaborative approach to their work. Preferable candidates will hold a science degree and will have proven experience of working within a research environment. We are looking for individuals who can provide an efficient administrative service and facilitate effective communication between the Programme, key internal stakeholders and external partners. Strong project management skills, as well as recent experience of handling budgets and producing high quality grant applications, reports and briefing materials will be advantageous. 

A willingness to be flexible, a key challenge of this role will be to maintain the appropriate balance between competing demands/priorities to deliver work in a timely fashion.

We are looking for motivated and enthusiastic individual with a desire to develop and progress. Our Administrative Career Development Programme means that there will be plenty of opportunity to expand your horizons with us. 

Reference:83473


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