Sanger Careers

Affiliate Jobs

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Current vacancies

Overview of the all job opportunities within Sanger.

Advanced Research Assistant - Mouse Molecular Technologies

Salary in the region of £26,693 to £30,000 per annum depending on experience plus benefits

We are are seeking an Advanced Research Assistant to join the Mouse Pipelines team. 

The Mouse Pipelines team is an essential component of a larger effort at the Sanger Institute to generate animal models of human disease, and to elucidate the function of genes via targeted knockouts and systematic phenotyping. As part this endeavour, we are seeking a highly motivated individual to join the Mouse Molecular Technologies group. 

You will determine the genotypes of mutant mice by PCR and real-time qPCR, and characterization of mutant alleles generated by targeted embryonic stem cells or CRISRP/Cas9 mutagenesis.

You will have substantial experience in molecular biology and PCR, and we in turn will offer the opportunity for you to gain additional skills within the group. 

Reference:83058


Advanced Research Assistant - Cancer, Ageing and Somatic Mutation Programme

Salary in the region of £26,693 - £32,299 (dependent on experience) plus excellent benefits

Permanent/ Open Contract

We are seeking an enthusiastic advanced research assistant to carry out both routine and more bespoke laboratory protocols and procedures. You will work as part of the support team providing solutions for the Cancer, Ageing and Somatic Mutation Programme led by Peter Campbell and other members of faculty at the Sanger Institute. Supervisory responsibility for the day-to-day operation of the laboratory will be a key requirement of the role and it will be expected that you will be able to use your skills and experience to trouble shoot and innovate where required. Excellent verbal and email communication is essential to keep both the team and senior staff fully appraised of progress.

Reference:83082


Communications Officer

Salary in the region of £26,000 to £28,000 per annum depending on experience plus additional benefits

The Wellcome Sanger Institute has been at the forefront of pioneering scientific research in genomics for the last 25 years. Our commitment to delivering big, bold exploratory research that pushes the boundaries of what is known and what is possible in genomics remains central to who we are and what we do. The Institute is a vital part of the Wellcome Genome Campus - home to some of the world's foremost institutes and organisations in genomics and computational biology, committed to delivering life-changing science with the reach, scale, and creativity to solve some of humanity's greatest challenges.

Our Communications team supports this work through telling the story of this important work across many internal and external communications channels.

We are growing our team and have created this brand new and exciting role to serve the communications needs of the Institute and Campus and are seeking a Communications Officer to join us.

  • You will support communications activity across the team.
  • You will support processes and develop materials and new processes where required.
  • You will be working and learning across all areas of Institute and Campus communications both internally and externally.

You will be self-motivated and driven to deliver high quality communications, you will be highly organised, focused with strong diplomatic skills, and be able to demonstrate strong persuasion and social skills and enjoy a dynamic, reciprocal and considerate environment.

Reference:83075


Computational Postdoctoral Fellow - CASM Programme

Salary £31,503 to £38,030 (dependant on experience) plus excellent benefits

Fixed term for 3 years

A postdoctoral position is available at the Wellcome Sanger Institute (WSI) under the leadership of Dr Peter Campbell as part of the Cancer Genome Project. This is an exciting opportunity for the successful candidate to explore the relationship between accumulation of somatic mutations in normal tissues and the development of cancer, with a focus on understanding the interplay between selective pressures, mutational processes and clonal structure.

The successful applicant will hold a PhD and will have gained significant experience and expertise in large-scale analyses of next-generation sequencing data and the mathematical and statistical modelling of complex data sets. He or she will be part of a multidisciplinary team and will be tasked with proactively seeking and maintaining appropriate collaborations. Successful candidates will also be expected to drive forward the project, working closely with biologists, clinicians and bioinformaticians within and outside the group to accomplish scientific objectives.

Reference:83026


Faculty Position in Cellular Genetics

The Wellcome Sanger Institute is seeking an exceptional early to mid-career stage scientist to join its Core Faculty to lead a research team in Cellular Genetics and contribute to the Institute’s scientific portfolio.

The Institute is an internationally outstanding genomic research centre with approximately 40 core Faculty teams and 1,100 employees based south of Cambridge. Our mission is to use genome sequences to advance understanding of the biology of humans and pathogens in order to improve human health. With core funding and state-of-the-art platforms in sequencing, model organisms, cellular genetics and IT, we enable our researchers to concentrate on biological questions across a diverse range of genomic and genetic science, in both independent studies and large-scale collaborations. The result is a unique, vibrant and interactive research environment with synergies and cross-fertilisation of ideas across and between programmes. 

We welcome candidates with research interests in cell atlasing, including single cell genomics, spatial gene expression methods and computation. We are also looking for candidates who want to apply these methods to specific biomedical research areas, and have expertise in protocol development with respect to tissue acquisition and processing.

Reference:83051


Finance Partner - Management Operations

Salary range: circa £52000pa plus excellent benefits

We are seeking to recruit a Finance Partner with a broad set of skills to provide flexible, proactive and timely financial expertise at the Wellcome Sanger Institute.

Working with a wide variety and large number of stakeholders you will provide intelligent financial reporting, modelling support and assistance to budget holders across the management operations division (COO, senior management, decision making committees) and the CFO. Alongside the Head of Financial Planning and Reporting, you will support on strategic initiatives and management decisions and provide expert financial guidance and opinion to assist non-finance professionals in developing budgets and managing their financial responsibilities.

Paramount to the success of this role is the ability for you to work independently, demonstrating initiative, creative thinking and problem solving and to build strong open and transparent working relationships with a wide variety and large number of stakeholders.

Effective time management, detailed forward planning and project management ensuring that the goals of finance and key stakeholders are being met is also key to this role. 

Reference:83060


HR Systems Analyst

Salary range £33,505 to £40,541 per annum (determined by experience), plus additional benefits

We are looking for a HR Systems Analyst to join our HR Services team who will have a meaningful role in the team to be the HR SaaS Information System (COREHR) expert.

You will maintain and develop the HRIS to ensure it works effectively for the business and is kept documented and compliant with both internal and legislative process.

Using your expert systems knowledge you will be responsible for ensuring data integrity, including quality, accuracy, security and usability of employee data, providing guidance on MI reporting.

You will take the lead in planning and implementing upgrades and additional modules with enhanced functionality and value add. Actively providing advice on best practice use of the system and future improvements and working with colleagues across the institute to ensure the delivery of an excellent customer experience and the evolving business requirements of the Institute are met.

Reference:83064


Head of High Throughput Gene Editing

Competitive salary and benefits package 

An exciting opportunity has arisen for a talented scientific manager to lead the High Throughput Gene Editing (HTGE) Core Facility here at the Sanger. The HTGE core facility is part of a cluster of core facilities at the institute, providing DNA sequencing, cell biology and mouse model skills and expertise to the wider institute.

The HTGE team is responsible for the high throughput generation of genetically modified cells and as such supports a wide range of research projects. Currently the team are focussed on the generation of CRISPR mediated gene knockouts in human iPS cells and produce approx. 100 gene knockouts per year.

As the Head of the HTGE core facility you will play a fundamental role in maintaining and developing a highly efficient, groundbreaking service. You will work with other teams across the other core facilities and the wider institute to develop and implement new genetic engineering processes to expand the portfolio of services on offer. As well as challenging the team to explore ways of improving quality and efficiency through new working practises, automation and process streamlining.

You will be providing leadership and direction to a team of approx. 10 scientists, mentoring staff, co-ordinating work and setting standards to ensure the continued high quality and timely delivery of gene editing projects.

Reference:83079


International Fellows Programme

The Wellcome Sanger Institute is seeking to appoint International Fellows to contribute to the Institute’s scientific portfolio.  Fellows should be early career stage scientists with existing faculty positions in a low or middle income country. Applications from senior scientists whose proposals are tightly aligned with the Institute’s strategic direction will also be considered.

The Institute is an internationally renowned genomic research centre with nearly 40 core faculty teams and 1,100 employees, based south of Cambridge. Our mission is to use genome sequences to advance understanding of the biology of humans and pathogens in order to improve human health. With core funding and state-of-the-art platforms in sequencing, model organisms, cellular genetics and information technology, we enable our researchers to concentrate on biological questions across a diverse range of genomic and genetic science, in both independent studies and large-scale collaborations. The result is a unique, vibrant and interactive research environment with synergies and cross-fertilisation of ideas across and between programmes. 

We welcome candidates with research interests that complement one of our four research programmes, bringing in new capacities and ideas.  Applications from exceptional individuals who have a different scientific focus within the broad field of genomics are also welcome. 

The successful candidate will initially be appointed for two years, with renewal for an additional two years upon successful review. Fellows will be allocated a yearly stipend that can be used to supplement salary costs at their home institution, as well as travel costs. Fellows are required to spend several months at the Wellcome Sanger Institute during the appointment, with access to the Institute’s research community and infrastructure.

Ideal Candidates

Ideal candidates will have typically completed a PhD or MD within the past 10 years while having completed at least three years in a post-doctoral or clinical setting.  Candidates with more experience will need to demonstrate a well-defined research agenda that is relevant to the Wellcome Sanger Institute and impactful to their home Institution.  All candidates need to be associated with an institute of higher learning, research centre, or hospital within a low or middle income country.

Reference:83042


Postdoctoral Fellow (Computational) - Hemberg Group

Salary in the region of £31,503 - £39,492 (dependent on experience) plus excellent benefits

Fixed term for 2 years

The Hemberg group is primarily interested in developing quantitative methods and models for analysing gene expression and gene regulation. We are particularly interested in working with data generated from high-throughput technologies, making sure that the software used to analyse this data is computationally and statistically rigorous. We are looking to appoint a computational post-doctoral fellow who is interested in applying their skills to transcriptomics and genomics. Prior experience of working with next-generation sequencing data is not necessary. We are looking for someone with strong mathematical and/or programming skills who is willing to learn about problems in molecular biology.

  • To carry out development of computational methods for analysis of high throughput genomics data, with a focus on single-cell analysis or regulatory genomics
  • To plan a programme of research that is original but fits within the general research area of the team, taking into account the relevant literature, own experience, and advice from the team leader and other appropriate scientists
  • To carry out the research, developing the practical skills required for successful completion
  • To analyse data and write up results for publication, and to deal with all aspects
  • of the publication process
  • To communicate the results through other relevant means, such as talking or presenting posters at scientific meetings
  • To seek appropriate training, including taking an active part in any training programmes organised for postdoctoral training fellows. This will include transferable skills training
  • To take a full part in the general duties of the team, and to pass on skills and knowledge to other team members and visitors. To take part in wider Sanger Institute activities as appropriate
  • To complete training period in a timely manner, publish the research and document any unpublished data and materials before moving on to a new position

The post-holder will work as part of the Hemberg group at WSI, for more information on the group’s research see: http://www.sanger.ac.uk/science/groups/hemberg-group

Postdoctoral Fellows are typically in their first or second postdoctoral position as part of a period of early career research training. Successful applicant(s) who have submitted their PhD thesis and are awaiting their PhD award are encouraged to apply. This position is initially for a fixed term of 2 years. For further information please contact Martin Hemberg on mh26@sanger.ac.uk

Reference:83048


Postdoctoral Fellow (Genome Assembly)

Salary range: £31,503 to £39,492 (depending on experience) plus excellent benefits

Fixed term contract for 3 years

We are looking for a highly motivated and experienced computational scientist to develop genome assembly algorithms using 3rd generation sequencing data. 

The Wellcome Sanger Institute is a world leader in genomic research, with an expanding scientific programme dedicated to understanding gene function in health & disease.

In the High Performance Assembly group, part of Sequencing Informatics, we develop algorithms and software tools for de novo genome assembly and sequence alignment for various applications. High profile projects such as the Genome10K Vertebrate Genome Project (VGP) and the Cancer Genome Project start to collect and sequence a large number of human and non-human samples, aiming for high quality de novo assemblies. The sequencing platforms include, but not limited to PacBio, Oxford Nanopore, 10X genomics, Bionano and HiC etc and the VGP consortium plans to combine various data types in order to produce assemblies with the best quality. The 2nd and 3rd generation sequencing technologies offer huge amount of sequencing output at massively reduced costs but the new datasets pose significant challenges in the assembly progress. To further strengthen our bioinformatics applications development, we are looking for outstanding computational scientists to join us working in this exciting area.

Reference:83035

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Postdoctoral Fellow (Population/Medical Genetics)

Salary in the region of £31,503 - £39,492 (dependent on experience) plus excellent benefits

Fixed term for 3 years

We are seeking to appoint a highly motivated postdoctoral fellow in human population/medical genomics to join Hilary Martin’s nascent group at the Wellcome Sanger Institute.

The fellow will lead new and exciting projects using data from large cohorts of individuals enriched for parental relatedness (consanguinity), including East London Genes and Health (currently N~30,000 British South Asians), Born in Bradford (N=12,000, ~half with Pakistani ancestry), and the Deciphering Developmental Disorders study (N=10,000 trios, mixed ancestries). Populations with high levels of autozygosity are understudied, so we have a limited understanding of whether and how the genetic architecture of diseases differs between them and other populations. Additionally, these populations have unique features that provide exciting research opportunities (e.g. a much higher rate of homozygous knockouts, which may be informative about new drug targets). We work closely with the individuals and populations we’re studying in community engagement and dissemination of our scientific findings.

The primary responsibility will be to deploy cutting-edge genomic analyses of exome sequencing and genotype chip data from populations with high rates of parental relatedness to explore fine-scale structure, its impact on disease risk, and genetic architecture of both rare and complex diseases. This will build on recent work in the group which has focused on quantifying differences in genetic architecture of rare developmental disorders between populations with varying levels of autozygosity.

The precise projects will be tailored to your interests and expertise, but could include investigating such questions as: 1) Does autozygosity impact complex traits, and if so, through which types of variation? 2) Does autozygosity contribute to rare disorders through mechanisms more complex than simple monogenic recessive inheritance? Can individuals with high autozygosity help us to understand incomplete/variable penetrance? 3) To what extent does the biraderi (clan) structure in Pakistani populations impact the distribution of disease-causing variation? There will also be an opportunity to work with electronic health record data in collaboration with the new Health Data Research UK institutes in Cambridge and London, and to do recall studies of individuals with rare knockouts to shed light on gene function and potentially identify new drug targets.

There is a strong commitment to personal and professional development within the group, and you will be encouraged to develop your own ideas and projects within the scope of the group’s interests, and build-up a strong academic profile.

You will work in close collaboration with multi-disciplinary teams at the Sanger Institute (particularly the Hurles group) and elsewhere. The post will benefit from the Sanger Institute’s capability for the generation and analysis of large-scale genetic datasets.

Reference:83056


Postdoctoral Fellow (Statistical Genomics)

Salary in the region of £31,503 - £39,492 (dependent on experience) plus excellent benefits

Fixed term for 3 years

We are seeking to appoint a highly motivated postdoctoral fellow in statistical genomics to join Hilary Martin’s nascent group at the Wellcome Sanger Institute.

The majority of genetic studies of disease have been conducted in populations with European ancestry, and many of the findings from these do not translate into other ethnic groups. Extending these studies to other populations is important for targeted risk prediction and personalized medicine. Our group focuses on genomics in understudied populations with high levels of parental relatedness (consanguinity), which have unique features that provide exciting research opportunities (e.g. longer runs of homozygosity, large pedigrees, higher rates of human knockouts, giving greater power for many analyses). We work closely with the individuals and populations we’re studying in community engagement and dissemination of our scientific findings.

You will drive exciting new projects using genomic data from large cohorts of richly phenotyped individuals enriched for parental relatedness, including East London Genes and Health (currently N~30,000 British South Asians), Born in Bradford (N=12,000, ~half with Pakistani ancestry) , and Deciphering Developmental Disorders (N=10,000 trios, mixed ancestries). You will work with electronic health record data in collaboration with the new Health Data Research UK institutes in Cambridge and London.

The primary responsibility will be to develop and implement methods for genomic analysis of large-scale exome sequencing and genotype chip data. The aim is to infer the role of population genetic processes in shaping genetic variation in populations with high rates of cousin marriage, and explore the contribution of autozygosity to the genetic architecture of rare and complex diseases and incorporate this into better population-specific risk predictors. The precise projects will be tailored to the successful applicant’s interests and expertise, but could include: 1) inferring which genes or genomic regions are under certain types of selection, and leveraging this to inform discovery of disease genes; 2) inferring historical patterns of parental relatedness, and estimating the age of variants under recessive selection; 3) quantifying the contribution of different types of genetic variation and inheritance modes to various diseases. The latter will build on recent work in the group which has focused on quantifying differences in genetic architecture of rare developmental disorders between different populations.

There is a strong commitment to personal and professional development with the group, and you will be encouraged to propose and develop your own ideas/methods within the scope of the group’s interests, and build-up a strong academic profile.

You will collaborate closely with other groups at the Sanger Institute (particularly the Hurles group) and elsewhere. The post will benefit from the Sanger Institute’s capability for the generation and analysis of large-scale genetic datasets, including a 15000+ core computational cluster, the largest in life science research in Europe, and multiple petabytes of high-speed cluster file systems.

Reference:83057


Postdoctoral Fellow - Cancer Dependency Map Analytics

Salary £31,503 to £39,492 (dependant on experience) plus excellent benefits

Fixed term for 3 years

The Wellcome Sanger Institute is seeking for a highly motivated researcher with strong skills in computational functional genomics to fill a postdoctoral fellow position, in collaboration with Open Targets. The aim of the fellow is to develop new algorithms and computational tools for the analysis of large-scale cancer pharmacogenomics and functional-genomics datasets to identify new oncology therapeutic targets and markers of gene-essentiality/drug-response.

To achieve this, the successful candidate will design methods to transform raw data into interpretable and predictive models via systematic statistical inference and unsupervised machine learning.  This will encompass integrating data generated in house from large scale in-vitro drug/genome-editing screens with the multi-modal characterization of the underlying models and that of cancer patients (from publicly available resources) in order to: (i) optimize/identify the most clinically relevant molecular determinants of gene-essentiality/drug-response; (ii) prioritize potential new targets/therapeutic-markers on the basis of unmeet clinical needs and translational potential.

The selected candidate will join the Cancer Dependency Map Analytics team and will actively interact with the international Cancer Dependency Map consortium, whose goal is to identify vulnerabilities and dependencies that could be exploited therapeutically in every cancer cell to advance personalized cancer treatments. The groups involved in this initiative have already characterized up to 1,000 cancer cell lines using high throughput genomic, transcriptomic, and proteomic techniques, as well as applied large scale drug panels to assess cell-line specific sensitivities. Work is currently ongoing to identify genes that inhibit cell growth when knocked out using CRISPR/Cas9 -- these could then be used as targets for therapies.

The successful candidate will perform original research to globally advance the state of the field with novel methods, data resources and results (applying methods and models to uncover new insight into cancer dependencies).

This position offers the opportunity to work at one of the world’s leading genomic centres at the forefront of genomic research. The successful candidate will have access to Sanger's computational resources, including a 15000+ core computational cluster, the largest in life science research in Europe, and multiple petabytes of high-speed cluster file systems.

We are part of a dynamic and collaborative environment at the Genome Campus and, although we seek someone who can work independently, the selected candidate will have the opportunity to interact with researchers across many Programmes at the Institute.

This PDF post is currently being advertised alongside a Postdoctoral Fellow– Modeling Gene Essentiality in Cancer (ref 83076) in Cellular Genetics 

Reference:83073

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Postdoctoral Fellow - Modeling Gene Essentiality in Cancer

Salary £31,503 to £39,492 (dependant on experience) plus excellent benefits

Fixed term for 3 years

The Wellcome Sanger Institute is seeking a highly motivated researcher with strong skills in computational genomics to fill a postdoctoral fellow position. The aim of the fellow is to develop a quantitative framework for predicting cancer vulnerabilities. To achieve this, the successful candidate will create generative probabilistic models that integrate the abundant data gathered in the international DepMap consortium for the available cancer cell lines, as well as apply deep neural networks and other suitable machine learning approaches to identify features to include in the model. Our collaborators in the consortium have world-leading expertise in cancer genomics to help guide model development.

The broader goal of the Cancer Dependency Map (http://depmap.org/sanger, and http://depmap.org/broad) is to identify a targetable vulnerability in every cancer cell. Ultimately, this will pave way for tumor-specific treatments. The groups involved have already characterized up to 1,000 cancer cell lines using high throughput genomic, transcriptomic, and proteomic techniques, as well as applied large scale drug panels to assess line-specific sensitivities. Work is currently ongoing to identify genes that inhibit cell growth when knocked out using CRISPR/Cas9 -- these could then be used as targets for therapies. The initiative is funded by OpenTargets (www.opentargets.org), a unique pre-competitive collaboration of companies and research institutions. As part of this effort, positions are also available for a bioinformatician to process genome-wide knock-out screen data, and a postdoctoral fellow to identify new therapeutic targets, and molecular markers of response to genetic and small molecule perturbations.

The successful candidate will perform original research in quantitative modelling of gene essentiality in cancer cell lines. The ultimate expected output is a model, that given a genome sequence and potentially additional molecular characterization, predicts the phenotypic impact of the knockout of each gene. It is important you have the ability to bridge from understanding the processes generating the observed data, to implementing computational pipelines to extract information and creating correct generative models for analysis. You are expected to make progress on your project as the first priority, while budgeting time for training in further skills, piloting new leads, and potentially collaborating on other projects. To function effectively in a multidisciplinary, collaborative setting, you have to be able to communicate well with scientists from diverse backgrounds, and be a pleasant colleague.

This position offers the opportunity to work at one of the world’s leading genomic centres at the forefront of genomic research. You will have access to Sanger's computational resources, including a 15000+ core computational cluster, the largest in life science research in Europe, and multiple petabytes of high-speed cluster file systems. Our group also has laboratory space and access to core facilities, where we generate our own data with the help of dedicated staff. This provides an exciting opportunity for you to not only analyse the data, but to be actively involved in the planning and execution of large-scale experiments.

We are part of a dynamic and collaborative environment at the Genome Campus and, although we seek someone who can work independently, you will have the opportunity to interact with researchers across Sanger, as well as our neighbours at the European Bioinformatics Institute.

This PDF post is currently being advertised alongside a Postdoctoral Fellow- Cancer Dependency Map Analytics (ref 83073) in Cancer Genomics

Reference:83076


Postdoctoral Fellow in Statistical and Computational Genomics

Salary in the region of £31,503 - £39,492 (dependent on experience) plus excellent benefits

Fixed term contract for 3 years

A postdoctoral position is available in the Wellcome Sanger Institute under the leadership of Dr Daniel Gaffney. The main research focus of our group is to understand how genetic variants influence cellular functions, using a mixture of statistical genetics, machine learning and high throughput functional genomics data. This post will focus on applications of single sequencing to problems in genetic mapping, in particular to cellular model systems based on human induced pluripotent stem cells. The post-holder will also have access to unique, large-scale functional genomics data sets generated human induced pluripotent stem cells that our group has developed as part of the Human Induced Pluripotent Stem Cells Initiative.

Candidates in Biology with a background in quantitative analysis and population genetics are strongly encouraged to apply. We also welcome candidates with a background in Physics, Statistics or Computer Science with strong interests in computational biology. Excellent programming skills, experience with very large data sets and an ability to work as part of a team are essential. The post-holder will work as part of the Gaffney group at WSI, for more information on the group’s research see:

http://www.sanger.ac.uk/science/groups/gaffney-group

The goal of our lab is to understand how regulatory variants alter cellular phenotypes using a variety of experimental and computational approaches. The Wellcome Sanger Institute offers a world-class academic environment, access to cutting edge sequencing facilities and extensive expertise in genome analysis and human genetics.

Postdoctoral Fellows are typically in their first or second postdoctoral position as part of a period of early career research training. Successful applicant(s) who have submitted their PhD thesis and are awaiting their PhD award are encouraged to apply. This position is initially for a fixed term of 3 years. For further information please contact Daniel Gaffney on dg13@sanger.ac.uk.

Reference:83046

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Postdoctoral fellow (Immune Screening) - Experimental Cancer Genetics

Salary range: £31,503 to £39,492 depending on experience plus excellent benefits

Fixed Term contract for 3 years

With the completion of the human genome and analysis of variation across multiple individuals, attention is now turning to the functional analysis of genes in mammals and their validation as therapeutic targets. Open Targets aims to provide evidence on the biological validity of therapeutic targets and provide an initial assessment of the likely effectiveness of pharmacological intervention on these targets, using genome-scale experiments and analysis. This pioneering public-private partnership between Biogen, Celgene, EMBL-EBI, GlaxoSmithKline, Takeda, and the Wellcome Sanger Institute, aims to provide a R&D framework that applies to all aspects of human disease, and to share its data openly with the scientific community (http://www.opentargets.org).

A new project funded by Open Targets, joint between the Experimental Cancer Genetics group headed by Dr David Adams at the Wellcome Sanger Institute together with Open Targets partners, is to perform in depth analysis of factors that control T cell survival and differentiation within the tumour microenvironment. This will involve the use of bespoke targeted CRISPR screens applied to primary cells and using in vivo tumour models in order to identify novel candidates genes and/or pathways for validation and in-depth characterization.

We are looking for a talented Postdoctoral Fellow to be responsible for the immune aspect of this project to include the isolation and culture of the T cells required the in vivoscreens and their subsequent isolation from tissues. You will follow the validation and characterisation phases of the project.

We offer a competitive reward package, including excellent benefits.

Postdoctoral Fellows are typically in their first or second postdoctoral position as part of a period of early career research training. You are encouraged to apply if you have submitted your PhD thesis and you are awaiting your PhD award.

Reference:83069

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Postdoctoral fellow (Statistical Genetics)

Salary up to £37,396 plus excellent benefits

Fixed term for 3 years 

Our group has a long-standing interest in the genetics of inflammatory bowel disease (IBD). IBD is a chronic, debilitating disorder of the gastrointestinal tract that affects around 0.5% of the population, with a typical onset in early adulthood. Many IBD patients ultimately require major abdominal surgery, resulting in lifelong disability, because an appropriate drug either does not exist or is not administered soon enough. Total healthcare costs in the UK are estimated to be over £1 billion per year. IBD pathogenesis is poorly understood but is likely driven by a dysregulated immune response to commensal gut microorganisms in genetically susceptible individuals. IBD is highly heritable and our group has played a leading role in the identification of 240 regions of the genome associated with disease susceptibility.

We are looking to appoint a statistical or computational postdoctoral fellow with an interest in complex disease genetics to take the lead on one of our large-scale sequencing based studies. As part of the UK IBD Genetics Consortium we are currently whole-genome sequencing over 15,000 IBD cases and 20,000 population controls at >15X coverage. This will enable us, for the first time, to powerfully test the entire allelic spectrum for association to IBD. Data from this project will be combined with that from multi-omic studies of disease-relevant cell types to identify new therapeutic targets for IBD.

The fellow will join a multi-disciplinary team of statisticians, geneticists, immunologists, computer scientists and clinicians who work together to understand the genetics and genomics of immune-mediated disease. The fellow will help shape the future direction of the research group and have the opportunity to develop their own research projects within the scope of the group’s interests. Supervisor - Dr Carl Anderson

Reference:83078

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Principal / Systems Support and Development Specialist

Principal System Support and Development Specialist: Salary IT Grade 1 - £47,773 to £57,806 per annum dependent on experience

Systems Support and Development Specialist: Salary IT Grade 2 - £37,739 to £45,664 per annum dependent on experience

We are looking for a Systems Support and Development Specialist to join the Data Services Architecture Team. You will be an integral part of the forward thinking and flexible team who provide critical services to their customers and are recognised for the value they provide.

The main objective of the role is to deliver high quality, customer focused Finance System (Unit4 Business World Milestone 6 – UBW-MS6) & other Corporate Applications support services to the Campus through the provision of technical support, training and solutions provision. This includes researching new technologies and developing appropriate solutions as required. The role should promote effective use of these applications at all times in order to support the research aims of the campus and the wider functions.

This role requires a high degree of communication and people skills to engage with the user community, including the 800 users of the UBW-MS6 application across the core modules; Finance, Logistics, PCB, Reporting (Excel, Excelerator and ARC) and the interface to the Jagger eMarketplace. You will learn quickly and as working as part of a team, understand complex software and database packages and be able to react quickly to change of customer & management requirements. You will be involved on-going development of the ERP system with more modules to be implemented and an on-going improvement plan to deliver, taking more responsibility for the dedicated management of change.

A broad range of experience in software service provision is required, but specific knowledge of the Unit4 Business World application is a significant advantage to deliver immediate value to the role. You will require to support a unique environment of leading edge scientific customers and those in more traditional finance and logistics departments. You will also be required to assist in architecting and specifying scalable but flexible Application solutions to deliver a high quality end user experience

Reference:83086


Public Health Web Software Developer - CGPS

Salary: upto £44525 plus excellent benefits

Fixed-term until: 30th September 2019

We are seeking an experienced web developer to work on an exciting and progressive project between the US Centers for Disease Control (CDC) and The Centre for Genomic Pathogen Surveillance (CGPS).

The role is focussed on providing generic data flow components to aid the linkage and interpretation of genomic and epidemiological information to inform understanding of the spread of pathogenic organisms.

To understand the spread of pathogens, data on their location, in both time and space, their public health impact, their likelihood of causing disease and other epidemiological data, often housed in different systems, need to be brought together and visualised in ways that enable public health workers and officials to inform decisions. Increasingly, genomic data are used to assess similarity between different samples and offer a huge leap in our understanding.

Bringing these data together provides exciting challenges, both logistically and from a data science and software development perspective.

You will help to assess data requirements, liaise with our core team of developers and implement a number of data flow components for pilot utility with a number of groups at the CDC. A set of reusable components will form the basis of a generic system focussed on open re-use both within the CDC and for broader utility within other CGPS projects and the wider community.

You will be a highly motivated and capable web developer with an enthusiasm for implementing generic, flexible and adaptable software components linked to interactive front-end visualisation tools such as Microreact.org.

Based at the Wellcome Genome Campus you will work with a team of developers, data scientists and genomic epidemiologists driven to provide interpretation tools to translate a wealth of genomic and epidemiological data into interfaces and outputs that can inform public health decision-making. Examples of existing applications that highlight technologies include

Microreact , Epicollect5 and WGSA.

 

Reference:83077


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