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Overview of the all job opportunities within Sanger.

Head of Programme - Tree of Life

Reporting to the Director of the Institute, the Programme Head will build and lead a scientific research team as part of a global consortium to deliver this visionary genome sequencing initiative and associated research programme. You will be a recognised authority in your field, who will take a lead in defining the strategy and scientific priorities for the Tree of Life programme in line with the Institute's mission to undertake leading edge genome research and provide insight into evolution and genetic variation, underpinned by large-scale, high throughput DNA sequencing. The role includes programme oversight, the recruitment of additional faculty to the programme, and active involvement in the senior management team steering the scientific and corporate direction of the Institute. 

You will be at the centre of the UK-wide Darwin Tree of Life Project, dedicated to sequencing all eukaryotic species in the UK (estimated at c66K), as well as representing the Institute within the International Earth Biogenome Project.  This will include collaboration and active engagement with scientists at the Royal Botanic Gardens, Natural History Museum-London, Smithsonian Institute, Max Plank Institute, Earlham Institute, and many others.

In addition to providing scientific leadership and contributing to the science delivered through the Tree of Life, the Programme Head will oversee the logistical aspects of programme such as sample collection and field-based protocols and will work closely with the Institute's sequencing and computational platforms.

The Head will be required to balance the complex people and project needs with programme strategy and resource considerations, and ensure effective and synergistic alignment of the programme with the wider Darwin and Earth Biogenome initiatives.

This is an open role subject to a 6-year review process

Reference:83214


Postdoctoral Fellow - Bacterial Evolutionary Biology

Salary in the region of £31,503 - £39,492 (dependent on experience) plus excellent benefits

Fixed term for 3 years

We are seeking a talented, motivated scientist with a strong interest in, and experience of, analyzing genomes and large genomic datasets to gain insights into the patterns and drivers of pathogen evolution. Ideally you would have biological or mathematical/statistics background with a demonstrated interest in developing bioinformatic skills or have proven track record of applying existing skills toward the analysis of complex genomic datasets. 

The position you are applying for falls within the Bacterial Genomics and Evolution faculty team, under the leadership of Professor Nick Thomson. We use genomic approaches to explore questions of basic science relating to the evolution and spread of bacterial pathogens in both humans and animals. We have established, over many years, strong collaborations with groups working on infectious diseases in local as well as national public health settings, NGO’s and leading research institutes around the world, providing access to people, resources and incredible datasets. We have a specialist interest in the evolution and spread of diarrhoeal disease (both the pathogen[s], their host[s] and the role of the microbiota) and tropical diseases. The team has a broad range of lab and informatics experience, and works collaboratively to analyse complex datasets with a history of developing novel informatics and lab-based approaches for accessing genomic and transcriptomic data.  

To help you see the type of work we have been doing, here is a selection of the team’s most recent publications. 

Tropical and diarrhoeal diseases:

Methods lab and in silico:

Antimicrobial resistance: 

In addition, these are important papers from other groups chosen to give you a sense of the team’s broader interests and areas/themes that they may wish to explore. 

If you wish to highlight a possible area of interest based on any of the papers above for further discussion, if shortlisted for an interview, please do highlight this in your application.  

This position would place you within a Faculty team within the Parasites and Microbes Programme, all set within a world leading genomics institute. You would be working closely with informaticians, wet-lab biologists, Postdoctoral Fellows and PhD students within the group and across this programme. You will be required to coordinate analysis of multiple project datasets and identify and establish new collaborations and projects, as well as to form part of an integrated team. The candidate will have substantial support and opportunities to broaden their skill-set and further their career.

Reference:83204


Postdoctoral Fellow - Bacterial Genomics and Evolution

Salary range: £31503 to £37305 per annum plus excellent benefits

Fixed-term for 3 years

We are seeking a talented, motivated and experienced bacterial genomics and evolution scientist who can actively coordinate analysis of multiple project datasets, develop new analysis protocols for use across the group and identify and establish new collaborations and new projects.

This is a rare and exciting opportunity for an experienced Postdoctoral Fellow or Staff Scientist to work within the Bacterial Genomics and Evolution team, under the leadership of Professor Nicholas Thomson. This team uses genomic approaches to explore questions of basic science relating to the evolution and spread of bacterial pathogens in both humans and animals.

Nick's team works in the areas of diarrhoeal disease and sexually transmitted infections (STIs). Research areas include the study of diseases such as cholera and dysentery that continue to cause significant mortality and morbidity in low-income countries.

A strong cross-cutting theme in our current work is the understanding of antimicrobial resistance (AMR); probably the most important driving force directing bacterial evolution in recent times. The team also has a history of developing novel approaches for accessing genomic and transcriptomic data, for example to enable direct sequencing of genomes from swabs without the need to culture.

You will have substantial opportunities for learning and development, working closely with informaticians, wet-lab biologists, Postdoctoral Fellows and PhD students across the Infection Genomics Programme.

The position requires someone who has shown ability to execute projects and deliver results at a practical level while working relatively independently. This position aims to bring wet-lab based research together with in silico analysis. You would have experience of both but the minimum criterion is experience in one but a deep an interest in both disciplines.

Reference:83209


Postdoctoral Fellow - Computational Biology (Haematological Cancer Genetics)

Salary in the region of £31,503 - £39,492 (dependent on experience) plus excellent benefits

Fixed term for 3 years

We are looking for a postdoctoral fellow to develop computational approaches for identifying individuals at risk of developing haematological malignancies using DNA sequencing data and high-throughput blood cell analysis from large numbers of individuals. The ultimate aim is to develop a robust approach for early detection of pre-leukaemia to drive future programmes for leukaemia prevention.

We recently reported that a significant proportion of individuals at high risk of developing acute myeloid leukaemia (AML) can be identified many years in advance (Abelson et al, Nature 2018). We also found that those at risk of AML displayed subtle changes in routine blood count parameters. The successful applicant will combine DNA sequencing with data from state-of-the-art haematology analysers and blood cell image analysis to augment our ability to identify individuals at risk of AML and related cancers.

You will have strong data analysis skills, be able to think around scientific questions creatively and feel comfortable interacting with other interdisciplinary team members, internal and external collaborators. You will be based within the Vassiliou Group  (Sanger) and work closely with the computational cancer biology research group (Moritz Gerstung) at the European Bioinformatics Institute EMBL-EBI.

Reference:83218


Postdoctoral Fellow - Statistical Genomics

Salary in the region of £31,503 - £39,492 (dependent on experience) plus excellent benefits

Fixed term for 3 years

We are seeking to appoint a highly motivated postdoctoral fellow in statistical genomics to join Hilary Martin’s nascent group at the Wellcome Sanger Institute.

The majority of genetic studies of disease have been conducted in populations with European ancestry, and many of the findings from these do not translate into other ethnic groups. Extending these studies to other populations is important for targeted risk prediction and personalized medicine. Our group focuses on genomics in understudied populations with high levels of parental relatedness (consanguinity), which have unique features that provide exciting research opportunities (e.g. longer runs of homozygosity, large pedigrees, higher rates of human knockouts, giving greater power for many analyses). We work closely with the individuals and populations we’re studying in community engagement and dissemination of our scientific findings.

You will drive exciting new projects using genomic data from large cohorts of richly phenotyped individuals enriched for parental relatedness, including East London Genes and Health (currently N~30,000 British South Asians), Born in Bradford (N=12,000, ~half with Pakistani ancestry) , and Deciphering Developmental Disorders (N=10,000 trios, mixed ancestries). You will work with electronic health record data in collaboration with the new Health Data Research UK institutes in Cambridge and London.

The primary responsibility will be to develop and implement methods for genomic analysis of large-scale exome sequencing and genotype chip data. The aim is to infer the role of population genetic processes in shaping genetic variation in populations with high rates of cousin marriage, and explore the contribution of autozygosity to the genetic architecture of rare and complex diseases and incorporate this into better population-specific risk predictors. The precise projects will be tailored to the successful applicant’s interests and expertise, but could include: 1) inferring which genes or genomic regions are under certain types of selection, and leveraging this to inform discovery of disease genes; 2) inferring historical patterns of parental relatedness, and estimating the age of variants under recessive selection; 3) quantifying the contribution of different types of genetic variation and inheritance modes to various diseases. The latter will build on recent work in the group which has focused on quantifying differences in genetic architecture of rare developmental disorders between different populations.

There is a strong commitment to personal and professional development with the group, and you will be encouraged to propose and develop your own ideas/methods within the scope of the group’s interests, and build-up a strong academic profile.

You will collaborate closely with other groups at the Sanger Institute (particularly the Hurles group) and elsewhere. The post will benefit from the Sanger Institute’s capability for the generation and analysis of large-scale genetic datasets, including a 15000+ core computational cluster, the largest in life science research in Europe, and multiple petabytes of high-speed cluster file systems.

Reference:83203


Postdoctoral fellow (Immune Screening) - Experimental Cancer Genetic

Salary range: £31,503 to £39,492 depending on experience plus excellent benefits

Fixed Term contract for 3 years

With the completion of the human genome and analysis of variation across multiple individuals, attention is now turning to the functional analysis of genes in mammals and their validation as therapeutic targets. Open Targets aims to provide evidence on the biological validity of therapeutic targets and provide an initial assessment of the likely effectiveness of pharmacological intervention on these targets, using genome-scale experiments and analysis. This pioneering public-private partnership between Biogen, Celgene, EMBL-EBI, GlaxoSmithKline, Takeda, and the Wellcome Sanger Institute, aims to provide a R&D framework that applies to all aspects of human disease, and to share its data openly with the scientific community (http://www.opentargets.org).

A new project funded by Open Targets, joint between the Experimental Cancer Genetics group headed by Dr David Adams at the Wellcome Sanger Institute together with Open Targets partners, is to perform in depth analysis of factors that control T cell survival and differentiation within the tumour microenvironment. This will involve the use of bespoke targeted CRISPR screens applied to primary cells and using in vivo tumour models in order to identify novel candidates genes and/or pathways for validation and in-depth characterization.

We are looking for a talented Postdoctoral Fellow to be responsible for the immune aspect of this project to include the isolation and culture of the T cells required the in vivoscreens and their subsequent isolation from tissues. You will follow the validation and characterisation phases of the project.

We offer a competitive reward package, including excellent benefits.

Postdoctoral Fellows are typically in their first or second postdoctoral position as part of a period of early career research training. You are encouraged to apply if you have submitted your PhD thesis and you are awaiting your PhD award.

Reference:83200

Documents:

Postdoctoral fellow - Experimental Cancer Genetics

Salary in the region of £31,503 - £39,492 (dependent on experience) plus excellent benefits

Fixed term for 3 years

CRISPR saturation mutagenesis to define cancer driver mutations and germline predisposing alleles

We are looking for a talented postdoctoral fellow to join our team at the Wellcome Sanger Institute. In this project you will use new genome editing techniques such as multiplex homology directed repair and base editing to pre-emptively identify all possible cancer pre-disposing alleles by saturation mutagenesis of cancer driver genes.

Classical genetic approaches for interpreting variants, such as case-control or co-segregation studies, require finding multiple individuals with each variant to associate that variant with a disease state. Because the majority of variants are present in only a small fraction of the population or are private to an individual, this strategy has clear limits. Fully realising the clinical potential of genetics requires that we accurately infer pathogenicity even for rare or private variation. Many computational approaches to predicting variant effects have been developed, but they can identify only a small fraction of pathogenic variants with high confidence. Experimentally measuring a variant's functional consequences can provide clearer guidance, but individual assays performed only after the discovery of the variant are both time and resource intensive. You will initially start with genes that predispose to melanoma development but we will ultimately extend this approach across all cancer genes.

This project is a collaboration between the labs of Dr. David Adams (https://www.sanger.ac.uk/people/directory/adams-david) and Dr. Andrew Bassett (https://orcid.org/0000-0003-1632-9137) from Experimental Cancer Genetics and Cellular Engineering, respectively, and is suitable for an energetic postdoctoral fellow with an interest in CRISPR technology and some computational experience. Informal enquires can be made to David Adams (da1@sanger.ac.uk) or Andrew Bassett (ab42@sanger.ac.uk).

Reference:83187


Principal Animal Technician - Research Support Facility

Salary in the region of £26,762 to £32,383 per annum plus benefits

We are looking for a Principal Animal Technician to join our team of licensed animal technicians within our Research support facility (RSF)

We have a state of the art animal facility providing a controlled environment for the mice, and fish housed within it using IVC technology.

Our state of the art facility provides;

  • a dedicated animal barrier,
  • germ free and containment giving provision for the housing and utilisation of model organisms in research in breeding colonies and experimental groups. 

You will be responsible for the supervision and mentorship of a small team of technicians and the co-ordination of technical procedures in a specific area. Promoting and maintaining husbandry and welfare care for the animals within a defined area. You will also be expected to tackle various projects and to drive the implementation of standards and initiatives within your allocated area in support of the RSF managers.

You will be required to participate in weekend/public holiday rota (approximately 1 weekend in 3) to ensure the RSF is satisfactorily maintained at all times

Reference:83192


Principal DevOps Engineer - Pathogen Informatics

Salary range up to £47,812 to £57,853 pa plus excellent benefits

Permanent 

We are seeking to recruit a Principal Development Operations Engineer to provide technical and infrastructural leadership for the Pathogen Informatics team. The Pathogen Informatics team work within the Parasites and Microbes programme to provide informatics solutions that can be translated into diagnostics, treatments or therapies that reduce global health burdens. We collaborate with scientists to develop novel software to accelerate genetics research.

The team is transitioning from traditional high performance computing infrastructure to a container based cloud environment running OpenStack. You will be the cloud and software container deployment technology authority. You will:

  • Have a real passion for solving difficult technical problems, from the network to the application stack
  • Have a focus towards automating everything and anything at scale
  • Spend time trying to determine how something works, not stopping with just knowing what it does
  • Want to make real API and back-end systems faster, more reliable, more efficient
  • Enjoy the challenge of dynamic projects, enjoy having broad and deep technical knowledge and are driven to iterate with new technologies
  • Work with the team leader and Principal Developers to develop the team's container deployment strategy
  • Orchestrate the execution of bioinformatics analysis pipelines, both on local systems as well as on cloud-based environments
  • Lead on a suite of software containers for deploying genomics analysis software
  • Interact with frontline helpdesk to receive reports and diagnose service interruptions
  • Join with other senior technical leaders in guiding institute wide technology initiatives, principles and practices

Our Team

Our team is based on the principles of agile development so that the software can be rapidly prototyped, updated regularly and receive rapid feedback from scientists in the Parasites and Microbes programme. The team employ a test-driven development strategy for all software development projects and strongly promote open source development using Github.

Reference:83195


Principal Software Developer - Pathogen Informatics

Salary range up to £47,812-£57,853 pa plus excellent benefits

Permanent

We are seeking to recruit a Principal Software Developer to provide technical and infrastructural leadership for the Pathogen Informatics team. The Pathogen Informatics team work within the Parasites and Microbes programme to provide informatics solutions that can be translated into diagnostics, treatments or therapies that reduce global health burdens. We collaborate with scientists to develop novel software to accelerate genetics research.

You will be responsible for the technical leadership and be the technology authority for the team. You will

  • Work with the team leader and Product Owners to clarify, elaborate, and iterate on the technology roadmap and designs.
  • Engage with team members through the daily scrum to remove blockers, work more efficiently, and produce high quality products.
  • Actively identify issues and opportunities and collaborate with other teams to achieve successful collaborations.
  • Assist with the personal development, mentoring and growth of junior developers to inspire, support and enable them to achieve their full potential.
  • Delegate responsibility where applicable and actively engage in key decision-making.
  • Join with other senior technical leaders in guiding institute wide technology initiatives, principles and practices.

Our Team

Our team is based on the principles of agile development so that the software can be rapidly prototyped, updated regularly and receive rapid feedback from scientists in the Parasites and Microbes programme. The team employ a test-driven development strategy for all software development projects and strongly promote open source development using Github.

Reference:83188


Research Administrator - Parasites and Microbes Programme

Salary range: £35642 to £43127pa plus excellent benefits

Permanent

The Wellcome Sanger Institute conducts ground-breaking genomic research on an unprecedented scale and our administration team plays a vital role in enabling and supporting our science. The Parasites and Microbes Programme is currently looking for a dynamic, visionary, and skilled Research Administrator to support the Programme, and join our pioneering organisation.

Providing dedicated support to the Head of Programme and their Faculty Teams within the Parasites and Microbes Programme, our Research Administrators need to take a collaborative approach to their work. With a desire to develop and progress you will already have experience of working within a research environment but will always be looking to share and develop knowledge further.

We are looking for individuals who can provide an efficient administrative service and facilitate effective communication between the Programme, internal stakeholders and external partners. Strong project management skills, as well as recent experience of handling budgets and producing high quality grant applications, reports and briefing materials will be advantageous. 

A willingness to be flexible, a key challenge of this role will be to maintain the appropriate balance between competing demands / priorities to deliver work in a timely fashion.

Reference:83194


Research Assistant - Cancer, Ageing and Somatic Mutations Programme

Salary in the region of £19,514- £23,612 (dependent on experience) plus excellent benefits

Permanent/ Open Contract

We are seeking an enthusiastic research assistant to carry out routine laboratory protocols and procedures. It will be expected that the successful candidate will be able to use their skills and experience to trouble shoot and innovate where required. They will work as part of the support team providing solutions for the Cancer, Ageing and Somatic Mutations Programme led by Peter Campbell and other members of faculty at the Sanger Institute.

 

Reference:83199


Senior Bioinformatician - Cancer Dependency Map Analytics

Salary £36,373 to £44,011, depending on experience plus excellent benefits

Fixed term for 3 years

The Wellcome Sanger Institute is seeking for an experienced Bioinformatician to provide computational support to the international Cancer Dependency Map consortium, and to other projects engaged in the analysis of data from genome-editing and functional-genomics screens, in collaboration with Open Targets.

The selected candidate will join the Cancer Dependency Map Analytics team, actively interacting with the Cancer Dependency Map consortium, whose broad goal is to identify vulnerabilities and dependencies that could be exploited therapeutically in every cancer cell.

The successful candidate will be able to extensively use computational pipelines for pre-processing and quality control assessment of data from genome-editing screens, and to implement new analytical pipelines on an individual project needs’ basis extending existing software, writing, documenting and maintaining code packages on public/internal repositories. Past experience with genomic data curation and familiarity with the management of data from large-scale in-vitro drug/functional-genomic screens will be positively considered.

Finally, the selected candidate will interact with Open Targets partners and collaborators, and with web development teams to coordinate data/results flows on the public domain.

This position offers the opportunity to work at one of the world’s leading genomic centres at the forefront of genomic research. The successful candidate will have access to Sanger's computational resources, including a 15000+ core computational cluster, the largest in life science research in Europe, and multiple petabytes of high-speed cluster file systems.

We are part of a dynamic and collaborative environment at the Genome Campus and, although we seek someone who can work independently, the selected candidate will have the opportunity to interact with researchers across many programmes at the Institute.

Francesco Iorio - Please contact francesco.iorio@sanger.ac.uk for informal enquiries

Reference:83193


Senior Software Developer - Human Cell Atlas & Teichmann Lab

Salary in the region of £40,850 - £49,428 (dependent on experience) plus excellent benefits

Fixed term for 3 years

Highly motivated Full-Stack Developer required to work on infrastructure for Big Data Genome analysis using OpenStack within the Teichmann laboratory at the Sanger Institute.

An exciting unique opportunity has become available to develop software infrastructure for Human Cell Atlas project (https://www.humancellatlas.org) which aims to increase our understanding of human body on a cellular level. The post holder will be part of the Teichmann group, working closely with colleagues in the core IT team of the Cellular Genetics division and the European Bioinformatics Institute.

Specifically, the post holder will contribute to developing a virtualised compute cloud infrastructure to allow our analysis workflows to be run in a distributed, adaptable and scalable environment. This position would suit a Software Developer who enjoys developing software solutions for large scale data analysis. The post holder will also apply these skills to building and improving the pipeline and portal development within the Teichmann/ Cellular Genetics team at the Sanger Institute.

We are looking for an individual who enjoys working in a multi-disciplinary team environment to help solve complex IT issues which will ultimately aid our understanding of the human body on a cellular level.

Reference:83190


Team Administrator - CASM - (Maternity Cover)

Salary in the region of £26,529 to £32,299 per annum, plus benefits

Fixed term contract - Maternity Cover

We have a new opportunity for an experienced and motivated Administrator to join the Cancer Ageing and Somatic Mutation Research Programme. You will be joining a small group of administrators that work closely with the Senior Management Team and their areas to support scientific delivery.

You will provide high level administrative support primarily to a number of faculty and senior management, plus their teams. This will include but will not be limited to:

  • diary management
  • meeting organisation and note taking
  • travel arrangements
  • expense claims and credit card reconciliations

You will be a confident administrator with the ability to see the bigger picture, spot areas of improvement and relish being part of a small supportive team, and be a visible contributor to the wider group as well as the organisation.

What we can offer you:

In addition to a competitive salary and a variety of benefits  you will have the opportunity to expand and develop your role over time, tackle new projects that excite and interest you, and contribute to the ongoing success of the Cancer Ageing and Somatic Mutation Research Programme. 

We value the insights of our support team and you will be invited to attend and be an active participant in team meetings and organisational initiatives.

Secondment Opportunity for Internal Candidates only:

We also welcome internal applicants wishing to pursue a secondment opportunity. Applicants must discuss their intentions with their line manager before applying to ensure this can be accommodated.

Reference:83197


Team Administrator - Cellular Genetics

Salary in the region of £26,529 - £32,099 (dependent on experience) plus excellent benefits

Permanent/ Open Contract

The Wellcome Sanger Institute conducts cutting edge genomic research on an unprecedented scale and our administration team plays a vital role in enabling and supporting our science.

We are seeking to appoint an experienced and highly skilled individual to provide a first-class and proficient service as a Team Administrator within the Cellular Genetics Programme at the Wellcome Sanger Institute.

The role will consolidate administrative, personal assistant and Programme support. This will include, but is not limited to, diary organisation and coordination, organisation of team and Programme meetings and seminars, providing support and arrangements for visitors to the Programme, facilitating travel for Programme faculty and teams, and other administrative tasks including purchasing, minuting meetings, completing paperwork, processing expenses and generally ensuring smooth operation of the Programme.

You will have previously provided a professional and high quality administrative service with recent experience of implementing and managing administrative systems, procedures and policies.

You should be a highly organised, efficient, self-motivated and energetic individual who is able to work independently in a dynamic environment with flexibility, adjusting to varying priorities and finding solutions to challenges that arise. You will need to be tactful and discrete in communication and respect confidentiality. The ability to build effective relationships with members of the Institute and external partners at all levels is essential. Your personal qualities will include professionalism, personal drive, trustworthiness and the ability to work collaboratively.

Reference:83196


16 records found