Overview of the all job opportunities within Sanger.
The Wellcome Trust Sanger Institute is located on the stunning Wellcome Genome Campus. Set over 125 acres, the campus hosts the biggest aggregate concentration of people in the world working on the common theme of Genomes and Biodata. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to solve some of humanity’s greatest challenges.
The Campus is a community of organisations working in genomic research, enterprise, education and discourse. It is home to some of the world's foremost institutes and organisations in genomics and computational biology, including the Wellcome Trust Sanger Institute which is the largest organisation on Campus, the European Bioinformatics Institute (EMBL-EBI), Open Targets and Genomics England. Also located here is Connecting Science - its mission is to enable everyone to explore genomic science and its impact on research, health and society by drawing on the ground-breaking research taking place on the Campus.More than ever before, the Institute is at the forefront of genetic discovery and emerging real-life health benefits as a result of the research that we do.
We are currently seeking a Director of Scientific Operations to lead the delivery of all of our scientific operations and high-throughput platforms to provide invaluable data and resources which are vital for our world-leading science. The post holder will be responsible for overseeing DNA pipelines (including R&D and informatics), Cellular Operations and in vivo models and customer relations. The role will continually evolve our services to embrace new technologies and the ever-changing demands of bold new scientific challenges.
Driving a committed culture which embraces innovation and collaboration you will provide oversight and direction to a team of 300 people and represent the Institute on a global platform. You will be a visionary and inspirational senior leader who can energise and empower others to achieve high performance in a rapidly changing science environment. With considerable experience of leading a large-scale research infrastructure, you will have the ability to engage deeply in the technical aspects of the Institute’s major pipelines when required. You will be adept at balancing the longer term strategic view whilst ensuring that day-to-day operations deliver.
This is an excellent opportunity for a highly skilled professional to contribute to the leadership of our Institute and shape the direction of our operations to reflect the strategic requirements of our research programmes and the vision of the Institute for the future.
Genome Research Limited is an Equal Opportunity employer. As part of our commitment to gender equality and promoting women’s careers in science, we hold an Athena SWAN Bronze Award. We will consider all qualified applicants without discrimination on grounds of disability, sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.
For an informal and confidential discussion about the role, please contact our advising consultants Juliet Taylor or Rebecca O’Connor on 020 7426 3373 at GatenbySanderson.
Closing date for applications is noon on Friday 12th January 2018
To view the job description and person specification, please click apply now which will take you Gatenby Sanderson website.
Salary range £25,411 to £30,995 per annum depending on experience
We are seeking a self-motivated and enthusiastic Advanced Research Assistant to join the DNA Illumina high-throughput Team within the DNA Pipelines department at the Wellcome Trust Sanger Institute.
The DNA Pipelines department (DNAP) has a central role within WTSI, delivering high quality data to our faculty and their collaborators over a range of techniques and platforms. These include, but are not limited to, Sequencing using Illumina & PacBio technologies, Genotyping using Illumina, Agena BioScience and Fluidigm technologies and BioNano Genome mapping. We have a Sample Logistics team providing import and export of samples globally and internally.
This is a laboratory based role where you will be responsible for generating DNA libraries in a high throughput environment using a variety of automation platforms (Tecan, Agilent Bravo and Beckman Coulter BioMek liquid handling platforms). Working as part of a team you will be expected to plan, organise and schedule own workload in line with priorities, interpret results to a pass / fail level and maintain equipment to ensure it is fit for purpose and operating within set validation criteria. The successful candidate will also be expected to help with the day to day running of the laboratory and be active and keep track of their own training records.
Excellent knowledge and practical experience of at least one of the platforms currently used in DNAP is a prerequisite for this role. Excellent organisational and planning skills in a busy environment would also be essential along with experience in the use of LIMS software.
You will have a strong understanding of the team product portfolio and the scientific theory underpinning the processes.
The Wellcome Trust Sanger Institute is seeking exceptional scientists to join the Institute as Associate Faculty, contributing to the Institute’s scientific portfolio in the area of synthetic genomics.
The Institute is an internationally outstanding genomic research centre with approximately 40 core faculty teams and 1,100 employees based south of Cambridge. Our mission is to use genome sequences to advance understanding of the biology of humans and pathogens in order to improve human health. With core funding and state-of-the-art platforms in sequencing, model organisms, cellular genetics and IT, we enable our researchers to concentrate on biological questions across a diverse range of genomic and genetic science, in both independent studies and large-scale collaborations. The result is a unique, vibrant and interactive research environment with synergies and cross-fertilisation of ideas across and between programmes.
We welcome candidates with research interests in synthetic genomics that may complement the research in one of our five research programmes bringing in new areas and ideas. Applications from exceptional individuals who have a different scientific focus within the field are also welcome.
The successful candidates will not be employed by the Institute, but will be expected to spend between 10-20% of their time focused on the development of their Sanger research programme, contributing to the scientific life of the Institute. Associate Faculty positions are accompanied with start-up funding to establish a small, independent team, engaged in research that cannot be conducted at their home organisation and enhanced by the Institute’s platforms, systems, and infrastructure. Associate Faculty will be expected to secure third party funding to support their research endeavour.
Associate Faculty Requirements
- Associated with a institute of higher learning or research centre
- Easily accessibility to the Wellcome Genome Campus
Up to £39,004 (depending on experience)
Fixed term for 2 years
The Sanger Institute Malaria Programme generates and analyses large-scale genome datasets in order to understand how Plasmodium genetics affects the biology and epidemiology of malaria, with a particular focus on host-parasite interactions. Interactions between Plasmodium and host proteins are of interest both for their fundamental biology, controlling for example which Plasmodium species are able to infect which hosts or which individuals develop severe or uncomplicated malaria, and because they are potential intervention targets, particularly for vaccine development. The Sanger Institute Malaria Programme uses a range of large-scale approaches, including protein-protein interaction screens, large-scale genetic studies and genome sequencing, to identify and study novel host-parasite interactions, such as that between the major Plasmodium falciparum vaccine candidate PfRH5 and its human receptor Basigin. Understanding the functional impact of variation in these interactions is key to understanding the biological story of human-parasite coevolution, as well as accelerating the process of vaccine development.
There is now an opening for a post-doctoral fellow to work in the Rayner lab to use the latest genetic, genomic and molecular tools to identify and investigate host-parasite interactions during Plasmodium falciparum erythrocyte stages. The postdoctoral fellows will develop and apply approaches such as CRISPR-Cas9 genome editing, quantitative mass spectrometry, RNAseq, and P. falciparum erythrocyteinvasion and phenotyping assays. The projects will require working closely with other group members at the Sanger Institute and also partners in the USA and in malaria endemic countries. The successful candidates will be independent, self-starters, and keen to make the most of this exciting opportunity. While these are funded positions, we believe that the rich biology has many possibilities for the development of new independent projects, and career development and support are a key element of the role.
Up to £39,004 (depending on experience)
Fixed term for 3 years
The Hemberg group is primarily interested in developing quantitative methods and models for analysing gene expression and gene regulation. We are particularly interested in working with data generated from high-throughput technologies, making sure that the software used to analyse this data is computationally and statistically rigorous. We are looking to appoint a computational post-doctoral fellow who is interested in applying their skills to transcriptomics and genomics. Prior experience of working with next-generation sequencing data is not necessary. We are looking for someone with strong mathematical and/or programming skills who is willing to learn about problems in molecular biology.
- To carry out development of computational methods for analysis of high throughput genomics data, with a focus on single-cell analysis or regulatory genomics
- To plan a programme of research that is original but fits within the general research area of the team, taking into account the relevant literature, own experience, and advice from the team leader and other appropriate scientists
- To carry out the research, developing the practical skills required for successful completion
- To analyse data and write up results for publication, and to deal with all aspects
- of the publication process
- To communicate the results through other relevant means, such as talking or presenting posters at scientific meetings
- To seek appropriate training, including taking an active part in any training programmes organised for postdoctoral training fellows. This will include transferable skills training
- To take a full part in the general duties of the team, and to pass on skills and knowledge to other team members and visitors. To take part in wider Sanger Institute activities as appropriate
- To complete training period in a timely manner, publish the research and document any unpublished data and materials before moving on to a new position
The fellow will help shape the future direction of the research group and have the opportunity to develop their own research projects within the scope of the group’s interests. Supervisor - Dr Martin Hemberg http://www.sanger.ac.uk/science/groups/hemberg-group
Salary up to £34,810 plus excellent benefits
Fixed term for 3 years
Our group has a long-standing interest in the genetics of inflammatory bowel disease (IBD). IBD is a chronic, debilitating disorder of the gastrointestinal tract that affects around 0.5% of the population, with a typical onset in early adulthood. Many IBD patients ultimately require major abdominal surgery, resulting in lifelong disability, because an appropriate drug either does not exist or is not administered soon enough. Total healthcare costs in the UK are estimated to be over £1 billion per year. IBD pathogenesis is poorly understood but is likely driven by a dysregulated immune response to commensal gut microorganisms in genetically susceptible individuals. IBD is highly heritable and our group has played a leading role in the identification of 240 regions of the genome associated with disease susceptibility.
We are looking to appoint a statistical or computational postdoctoral fellow with an interest in complex disease genetics to take the lead on one of our large-scale sequencing based studies. As part of the UK IBD Genetics Consortium we are currently whole-genome sequencing over 15,000 IBD cases and 20,000 population controls at >15X coverage. This will enable us, for the first time, to powerfully test the entire allelic spectrum for association to IBD. Data from this project will be combined with that from multi-omic studies of disease-relevant cell types to identify new therapeutic targets for IBD.
The fellow will join a multi-disciplinary team of statisticians, geneticists, immunologists, computer scientists and clinicians who work together to understand the genetics and genomics of immune-mediated disease. The fellow will help shape the future direction of the research group and have the opportunity to develop their own research projects within the scope of the group’s interests. Supervisor - Dr Carl Anderson
Salary in the region of £19,000 plus excellent benefits
Fixed term for 2 years
The Genomics of Drug Sensitivity in Cancer group focuses on understanding the consequences of alterations in the DNA of cancer cells. We do this at scale using multiple approaches including drug sensitivity screens in cancer cell models. Vulnerabilities within cancer cells identified from the data generated can then be exploited as novel drug targets or as genetic markers for patient selection.
To support this research we are seeking a Research Assistant to join the drug sensitivity screening team to perform high-throughput viability assays in cell lines and organoid models. The role will be based in the laboratory focusing on culturing the cell models, preparing and processing micro-well assay plates.
The screening team manages over 1000 cancer cell models requiring individuals to demonstrate excellent organisational and time management skills in order to meet project deadlines and weekly schedules. The biological assays utilise state of the art automation platforms and sample management systems to process and track experiments through the lab. Experience in cell culture and associated techniques or high-throughput laboratories would be an advantage although not essential. The highly integrated work requires excellent communication skills to co-ordinate tasks, equipment and model information between team members.
The working week for this position includes Saturday however we are open to discuss the most suitable pattern for the remaining four days (Monday-Friday).
Salary: grade 1 in the region of £43,182 - £52,250 (dependant on experience) plus excellent benefits
Fixed Term for 3 years
We are seeking to appoint a statistical epidemiologist to conduct real-world statistical analyses in the busy Global Health and Populations Research Group, co-located between the Wellcome Trust Sanger Institute and the University of Cambridge, led by Dr. Manjinder Sandhu. Our group assesses the burden and aetiology of chronic diseases among populations, integrating principles and procedures underlying epidemiology, genomics and public health, with a strong interest in global health.
The successful applicant will work on analysing real-world data in the field of genomics and electronic health records (EHRs). This will include planning and undertaking complex statistical analyses of longitudinal data with repeated measures to assess epidemiological associations between multiple exposures and disease outcomes. They will also provide statistical input into protocols, study reports and papers for publication.
We are looking for someone who has substantial experience in data harmonisation and statistical analysis of large-scale longitudinal data from electronic health record databases in the UK, informed by an understanding of the structure and format of these databases. They should be able to work independently to plan and deliver statistical analyses, as well as devise the statistical methodology for observational research projects. Furthermore, they should be able to evaluate existing statistical methods in different data contexts, as well as devise novel statistical methodology for projects where existing methods have recognised limitations.
As a senior postholder in the research group, the successful applicant will also contribute statistical support to other global health research projects within the group as required; help to develop scientific goals for related projects and coordinate activities and interact with other members of the group so that goals are met; contribute to publications or disseminate research findings; and contribute to the process of securing funds.
This post provides a unique opportunity to lead large-scale epidemiological studies involving statistical analyses of millions of individuals, in the context of population health and genomics globally.
Salary range: £43182 to £52250pa plus excellent benefits.
Fixed term for 3 years
We are seeking a talented, motivated and experienced Senior Staff Scientist at the Wellcome Trust Sanger Institute, under the leadership of Dr Trevor Lawley (www.lawleylab.com). We are expanding the germ free/gnotobiotic capability for controlled-microbiome studies, and are looking for a Senior Staff Scientist to work closely with Dr Trevor Lawley and other members of the Sanger Institute, to provide operational and scientific leadership.
This is an exciting opportunity for the successful candidate to join a dynamic team investigating the role of the microbiota in human health and a variety of diseases, such as autoimmunity, infections and cancers, using genomics, microbiology and model organisms. There is a strong translational focus to the Lab with the goal of developing novel, microbiome based diagnostics and therapeutics.
The successful applicant will have experience in designing and executing mouse experiments and managing mouse colonies. Key responsibilities include, facilitating and building a strong host-microbiota interactions programme to build on the current understanding of the interactions with disease areas such as cancer, immune system modulation, and infection. The successful candidate will be part of a multidisciplinary, collaborative team and will be expected to work closely with existing team members to accomplish scientific objectives and proactively identify, establish and develop new collaborations and new projects and publications.
You will have substantial opportunities for learning and development, working closely with informaticians, wet-lab biologists, Postdoctoral Fellows and PhD students.
Salary in the region of £50,000 plus excellent benefits
Fixed Term for 8 months
The Wellcome Trust Sanger Institute and Centre for Genomic Pathogen Surveillance is seeking a motivated and talented Web Software Engineer to focus on data processing / visualisation and delivery of genomic data, via the web, as part of the Gates Funded Global Pneumococcal Sequencing Project. The postholder will work within a team expanding and improving bioinformatics services, increasing code test coverage and automated integration testing. The postholder will also have domain responsibility for delivery of information to the community of pneumococcal researchers, public health labs and policy makers key in influencing decisions based on outputs of data analytics.
The most complex part of the role will be the development of scalable visualisation, management of data and collaborators for delivering analysis of complex biological datasets from whole genome sequences of pneumococcal pathogens.
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