Current vacancies

Advanced Research Assistant - Cellular Generation and Phenotyping

Salary range £26,693 to £32,299 per annum depending on experience, plus benefits

An opportunity has arisen for a talented cell biology specialist to support the Cellular Generation and Phenotyping team (CGaP) here at the Sanger Institute. You will be working as a part of a team on induced pluripotent stem cell (iPSC) differentiation into neuronal lineages using both wild type and knock out iPSCs.

 Have you ever worked in a R&D, high throughput or process driven setting?

• Do you have experience working in a CL2 laboratory?
• Are you organised, meticulous and love process improvement?
• Do you thrive in a multi-disciplinary team, working together to solve complex biological issues?

If you said yes to the above questions, then this could be the job for you.

We are a core facility, responsible for providing cell biology resource and expertise to the wider institute. We do this by running multiple, diverse, high throughput projects for various faculty teams from across the Sanger Institute. Our current portfolio of projects includes genome wide CRISPR screens, iPSC derivation and differentiation, organoid derivation, The Human Cell Atlas Initiative and the generation of Plasmodium mutants. We work closely as a team of Senior Scientific Managers, Research Assistants and Faculty members to successfully deliver large scale projects.

As an Advanced Research Assistant you will play a fundamental role in expansion, banking and differentiation of iPSCs into neural stem cells and terminally differentiated neurons. Working in partnership with faculty teams you will enable the project to run at scale. The role requires you to aid in the tracking and progress of project to ensure a high quality of work and see the project through to completion.

Here at CGaP you will be part of an experienced team of enthusiastic, highly motivated Research Assistants, under the management of a Senior Scientific Manager. Your role will include the culture and manipulation of iPSCs in the lab, co-ordinate the transfer of samples to and from the faculty team, troubleshoot issues, identify areas for process improvement as well as training more junior staff.

In addition to the lab work we expect our Advanced Research Assistants to have strong time management and organisational skills and be excellent communicators. As a department we strive to work together where possible to build a culture of continuous process improvement. We also expect and support all staff to take part in department and institute wide initiatives.

This is an excellent opportunity for a motivated and adaptable individual to support the cutting edge science delivered within Cellular Generation and Phenotyping.

Reference:83282

Faculty Position in Human Cellular Genetics

The Wellcome Sanger Institute is seeking an early/mid-career stage scientist to join its Core Faculty to lead a research team in Human Cellular Genetics. Positions carry a significant core package of salaries and support backed by rewarding and flexible employment terms including excellent benefits and relocation support. Our exceptional core funding enables faculty to focus their energy on science.

We welcome candidates with research interests in the area of human cellular genetics. This could involve natural or engineered genetic variation, primary cells or cell-lines. Examples of relevant research programmes could include:

• delineating the genetic determinants of cellular phenotypes,
• applying cellular genomic technologies (e.g. dCas9) to investigate genetic associations with common diseases, rare disorders or quantitative traits,
• using genome editing, or multiplexed assays of variant effect, to determine the functional impact of genetic variants

We strongly encourage potential applicants to interpret this description broadly.

The Institute is a unique, vibrant and interactive research environment with an internationally outstanding genomic research centre at its heart. With approximately 35 core Faculty teams and 1,100 employees based south of Cambridge, UK, our mission is to use genome sequences to advance understanding of the biology of humans and pathogens in order to improve human health.

With core funding and state-of-the-art platforms in sequencing, high-performance computing, model organisms, genome editing and cellular genetics, we enable our researchers to concentrate on biological questions across a diverse range of genomic and genetic science, in both independent studies and large-scale collaborations. 

The Sanger Institute is at the forefront of human disease genetics, genome editing in cells, single cell RNA-seq, and large-scale derivation, differentiation and characterisation of iPSCs, cell-lines, primary cells and organoids.

Reference:83255

Grants Manager

Salary range £33,597 to £40,652 per annum depending on experience plus benefits

We are seeking a highly motivated Grants Manager to join our team at the Wellcome Sanger Institute to oversee the acquisition and management of funding for research projects.

You will require strong interpersonal skills as we work across a large network both internally and externally, building positive relationships and advising on grant related matters.

You'll play a vital role in the team working alongside researchers, across management operations and also in communication with research funders, offering great exposure for someone looking to develop their career in a research operations setting. 

Reference:83285

HR Apprentice

Salary £17,045 per annum plus benefits 

We have an exciting opportunity in our HR Team, for someone who has a keen interest in making the first step towards developing a career within Human Resources. We have created a 2-year rotational HR Apprenticeship where you will experience full exposure to the HR function.

During your apprenticeship journey you will contribute to a variety of projects whilst having the opportunity to learn new skills and gain experience in all aspects of HR within a supportive and encouraging team.

You'll be given real responsibility from the beginning and as a HR Apprentice you will spend the duration of your apprenticeship rotating around the team working within HR Services, Recruitment, HR Business Partnering Team, Engagement, Learning & Development and HR Projects.

You will be able to commence your Apprenticeship in September 2019, and work towards gaining the HR Support, Level 3 Apprenticeship. 

Reference:83272

Head of Operations - Parasites and Microbes Programme

Salary in the region of £70,000 to £80,000 (dependent on experience) plus excellent benefits

Permanent/ Open contract

The Wellcome Sanger Institute is one of the premier centres of genomic discovery and understanding in the world. It leads ambitious collaborations across the globe to provide the foundations for further research and transformative healthcare innovations. Its success is founded on the expertise and knowledge of its people and the Institute seeks to share its discoveries and techniques with the next generation of genomics scientists and researchers worldwide.

The Institute is built around four research programmes, each supported by operational teams which play a vital role in enabling and supporting the science. The Parasites and Microbes Programme is currently looking for a dynamic, motivated, and skilled Head of Operations who can bring together a range of research support services across the Programme into a cohesive, service oriented team of approximately 30 people. 

Research services include: Informatics (software development, application management and data analysis), laboratory management and support, grant applications and management, financial management, and administration support.  Although it is desirable to have experience in at least one of these areas, we are looking for an individual who is passionate, hardworking and highly motivated with previous operational leadership of multiple, distinct and varied services.  Furthermore, the proven ability to lead people through change is also essential.

You will need to take a collaborative approach to your work, balancing the needs of the Programme against the Institute’s goals. You will likely hold a degree and must exhibit excellent communication and negotiation skills.  You will have a track record of building trusted and effective working relationships with teams, customers and other key stakeholders both within and outside of the Institute.

Please contact John Sillitoe john.sillitoe@sanger.ac.uk for further information regarding the role.

Reference:83278

Maintenance Technician- RSF Equipment

Salary range £20,250 to £24,503 per annum depending on experience plus benefits

We are looking for a maintenance technician to join our engineer team within the Research Support Facility (RSF) to provide continued support to the automation and specialist equipment used.

We have a state of the art animal facility providing a controlled environment for the mice, rats, hamsters and fish. The facility provides a dedicated barrier and non barrier area to support IVC and isolator housing provision to our breeding colonies and experimental model organisms.

You will be responsible for the smooth running and upkeep of the specialist equipment and machinery in the RSF. This will include the routine servicing and maintenance, troubleshooting equipment faults and keeping an inventory of spare parts. You will ensure Health and Safety compliance and adherence to Standard Operating Procedures and Risk Assessments.

When required you will assist with the broader duties of the RSF support team, which may include operating specialised equipment, dispersal and collection of cages and water bottles, ensuring high levels of cleanliness are maintained, receiving, and distributing deliveries.

You will be required to participate in some outside normal hours working and at weekends/public holidays to ensure the RSF is satisfactorily maintained at all times.

Reference:83277

Postdoctoral Fellow - Statistical Genomics

Salary in the region of £31,503 - £39,492 (dependent on experience) plus excellent benefits

Fixed term for 3 years

We are seeking to appoint a highly motivated postdoctoral fellow in statistical genomics to join Hilary Martin’s nascent group at the Wellcome Sanger Institute.

The majority of genetic studies of disease have been conducted in populations with European ancestry, and many of the findings from these do not translate into other ethnic groups. Extending these studies to other populations is important for targeted risk prediction and personalized medicine. Our group focuses on genomics in understudied populations with high levels of parental relatedness (consanguinity), which have unique features that provide exciting research opportunities (e.g. longer runs of homozygosity, large pedigrees, higher rates of human knockouts, giving greater power for many analyses). We work closely with the individuals and populations we’re studying in community engagement and dissemination of our scientific findings.

You will drive exciting new projects using genomic data from large cohorts of richly phenotyped individuals enriched for parental relatedness, including East London Genes and Health (currently N~30,000 British South Asians), Born in Bradford (N=12,000, ~half with Pakistani ancestry) , and Deciphering Developmental Disorders (N=10,000 trios, mixed ancestries). You will work with electronic health record data in collaboration with the new Health Data Research UK institutes in Cambridge and London.

The primary responsibility will be to develop and implement methods for genomic analysis of large-scale exome sequencing and genotype chip data. The aim is to infer the role of population genetic processes in shaping genetic variation in populations with high rates of cousin marriage, and explore the contribution of autozygosity to the genetic architecture of rare and complex diseases and incorporate this into better population-specific risk predictors. The precise projects will be tailored to the successful applicant’s interests and expertise, but could include: 1) inferring which genes or genomic regions are under certain types of selection, and leveraging this to inform discovery of disease genes; 2) inferring historical patterns of parental relatedness, and estimating the age of variants under recessive selection; 3) quantifying the contribution of different types of genetic variation and inheritance modes to various diseases. The latter will build on recent work in the group which has focused on quantifying differences in genetic architecture of rare developmental disorders between different populations.

There is a strong commitment to personal and professional development with the group, and you will be encouraged to propose and develop your own ideas/methods within the scope of the group’s interests, and build-up a strong academic profile.

You will collaborate closely with other groups at the Sanger Institute (particularly the Hurles group) and elsewhere. The post will benefit from the Sanger Institute’s capability for the generation and analysis of large-scale genetic datasets, including a 15000+ core computational cluster, the largest in life science research in Europe, and multiple petabytes of high-speed cluster file systems.

Reference:83203

Principal Bioinformatician - Experimental Cancer Genetics

Salary in the region of  £43,722- £52,903 dependent on experience) plus excellent benefits

Fixed term for 5 years

The Experimental Cancer Genetics group aims to identify cancer genes and to understand their function (https://www.sanger.ac.uk/research/faculty/dadams/). We are also interested in how genes interact to promote cancer development, and how these interactions may be exploited for therapy. Examples of recent studies include the identification of genes associated with familial melanoma (1), pan-drivers of cancer development (2), and genes that regulate genomic stability (3). The group is a mixture of pure wetlab, mixed wet/dry lab students and postdocs; with computational support provided by two Senior Bioinformaticians.

We are now seeking to recruit a Principal Bioinformatician who can facilitate the scientific work of the group by leading the computational data analysis support for the team and their collaborators. Many of our experiments involve the generation of large quantities of either whole-genome or exome sequencing data which require strong computational skills to 1) create high quality mutation calls 2) carry out statistical analysis to interpret the functional consequences 3) evaluate newly published tools to identify new types of mutations or signatures of mutation. Integrating genomic data with other data forms is also another important part of what we do. The group also performs CRISPR screens and uses the last analysis tools to explore these data.

The post-holder must be a good communicator and be able to understand the scientific background and technical detail of the team's projects, and be to be proficient at devising and implementing software solutions and statistical analysis. The role would also involve line management and day to day supervision for bioinformaticians in the team. This role would suit somebody with significant previous bioinformatics experience who wishes to gain knowledge of next-generation sequencing technologies and analyses, although experience with next-gen data is highly desirable. The successful candidate will work in conjunction with other computational biologists in the group and with other teams at the WSI.

 (1) Wong et al. (2018) Cross-species genomic comparison of human mucosal, canine oral and equine melanoma. Nature Communications – in press.

(3) van der Weyden et al., (2017) Genome-wide in vivo screen identifies novel host regulators of metastatic colonization. Nature, 12:233-236

(3). Robles et al., (2014) POT1 loss-of-function variants predispose to familial melanoma. Nature Genetics, 46:478-481

Reference:83293

Principal Software Developer - Cancer Genome Analysis

Salary in the region of  £47,812 - £57,853 dependent on experience) plus excellent benefits

3 Years Contract

The Translational Cancer Genomics Group investigates how abnormalities in the DNA of cells contribute to cancer and impact on patient responses to therapy. This provides fundamental insights into disease mechanisms with implications for the development of improved therapies (https://www.sanger.ac.uk/science/groups/garnett-group). The lab is a mixture of wet-lab experimental and data scientists.

We are seeking to recruit a Principal Software Developer to facilitate the work of the group by supporting the computational analysis of next-generation sequencing datasets.  

The primary role will be to conduct the genetic analysis of hundreds of new cancer models being generated as part of the Human Cancer Model Initiative (https://www.sanger.ac.uk/science/collaboration/human-cancer-model-initiative-hcmi / https://ocg.cancer.gov/programs/HCMI). The candidate will ideally have experience in the analysis of next generations sequencing data (WGS, RNAseq), including calling of single nucleotide variants, detecting copy number alterations, analysis of mutational signatures and clonal dynamics, and analysis of gene expression data. The candidate should have experience in statistics as well as working with state-of-the-art algorithms. The candidate will also have the opportunity to integrate genomic datasets with results from systematic drug testing and genetic screens, and will support the work of students and postdocs in the laboratory.

The post-holder must be a team player and good communicator, and be able to understand the scientific background and technical detail of the team's projects. The candidate will be proficient at devising and implementing software solutions and statistical analyses. This role would suit somebody with significant previous bioinformatics experience and experience with next-generation sequencing data analysis. The successful candidate will work in conjunction with other computational biologists in the group and the wider Cancer Programme at the Sanger Institute.

Reference:83273

Programme Manager - Health Data Research UK Cambridge

Salary range from: £55,000 to £75,000pa dependent on experience.

Health Data Research UK Cambridge is looking to recruit an energetic, enthusiastic and skilled Programme Manager to join our pioneering organisation. The role will be based at the Wellcome Sanger Institute on the Wellcome Genome Campus.

Formed in April 2018, Health Data Research UK (HDR UK) has six UK sites, comprising 22 universities and research institutes, whom work collaboratively as foundation partners to make game-changing improvements in people’s health by harnessing data science at scale across the UK. HDR UK Cambridge is based at the Wellcome Sanger Institute and its collaborative partners are:

• Wellcome Sanger Institute
• EMBL-European Bioinformatics Institute
• Cambridge University Hospitals NHS Foundation Trust
• University of Cambridge

Our preferred candidate will provide a dedicated operational and administrative support to the Director, Associate Directors and their teams.  You will need to take a collaborative approach to your work demonstrating excellent networking and relationship building. You will hold a science degree (or have equivalent experience) and will have experience of working within a research environment. We are looking for individuals who can provide an efficient operational and administrative service within a fast-paced environment and facilitate effective communication between the Programme and key internal and external partners. Strong project management skills, as well as recent experience of handling budgets and producing high quality grant applications, reports and briefing materials will be advantageous.

We are looking for a motivated and enthusiastic individual with a desire to develop and progress. If you think you have the attributes, skills and experience that we are looking for, please go to our job description and recruitment pack to find out more.

Reference:83289

Public Engagement-Administration and Events Officer (Maternity Cover)

Salary range £26,000 to £31,000 per annum depending on experience plus excellent benefits.

Fixed Term-Maternity Cover.

Wellcome Genome Campus Connecting Science is looking for an enthusiastic Administration and Events Officer to join our dynamic Public Engagement team.

Reporting to the Head of Public Engagement, you will handle the Public Engagement events calendar while taking responsibility for the organisation of some flagship event projects, including our European Researchers’ Night (LifeLab) and Café Sci Cambridge.

As well as providing support to the Head of Public Engagement and wider team, you will act as the first point of contact for the many and varied enquiries coming from a range of communities and partners. Your role will also include the organising of schedules for public and schools groups and liaising with key partners to ensure the successful delivery of our growing calendar of exciting events.

Reference:83253

Research Assistant

Salary range £20,000 to £23,612 per annum depending on experience plus benefits

Fixed term 3 year contract 

Phenotyping team (CGaP) at the Sanger Institute. You will be working as a part of a team on induced pluripotent stem cell (iPSC) differentiation into neuronal lineages using both wild type and knock out iPSCs.

Do you love working in a high throughput or process driven setting?

• Are you organised, meticulous and love process improvement?
• Do you thrive in a multi-disciplinary team, working together to tackle complex biological issues?

If you said yes to the above questions, then this is the job for you.

We are a core facility, responsible for providing cell biology resource and expertise to the wider institute. We do this by running multiple, diverse, high throughput projects for various faculty teams from across the Institute. Our current portfolio of projects includes genome wide CRISPR screens, iPSC derivation and differentiation, organoid derivation, The Human Cell Atlas and the generation of Plasmodium mutants. We work closely as a team of Senior Scientific Managers, Research Assistants and Faculty members to successfully deliver large scale projects.

As a Research Assistant you will play a fundamental role in expansion, banking and differentiation of iPSCs into neural stem cells and terminally differentiated neurons. Working in partnership with faculty teams you will enable the project to run at scale. The role requires you to aid in the tracking and progress of project to ensure a high quality of work and see the project through to completion.

Here at CGaP, you will be part of an expert team of enthusiastic, highly motivated Research Assistants, under the management of a Senior Scientific Manager. Your role will include the culture and manipulation of iPSCs in the lab, co-ordinate the transfer of samples to and from the faculty team, troubleshoot issues, identify areas for process improvement as well as training more junior staff.

In addition to the lab work we expect our Research Assistants to have strong time management and organisational skills and be excellent communicators. As a department we strive to work together where possible to build a culture of continuous process improvement. We also expect and support all staff to take part in department and institute wide initiatives.

This is an excellent opportunity for a motivated and adaptable individual to join the team in delivering high quality science.

Reference:83284

Risk Manager

Salary range: £44,803 to £54,211 per annum depending on experience plus benefits

An exciting opportunity has arisen for a Risk Manager at the Wellcome Sanger Institute.

You will have the opportunity to shape the whole risk management environment at the Institute and in the wider campus operations. This role combines elements of strategic and operational risk (including managing disaster recovery) and offers the opportunity to get involved in all aspects of the organisation, adding real value.

As a respected source of risk management knowledge you'll provide guidance and support to others helping to establish an appropriate framework and culture and taking responsibility for risk training and awareness. Using your influencing skills you will ensure that the appropriate attention is directed towards strategic and operational risks and their management.

You will maintain and manage the strategic risk register and provide specific direction and input in developing and rolling out the disaster recovery plan. You will also assist with the development of departmental / cross functional operational risk registers and appropriate risk mitigation strategies.

You will assess proposed changes to key policies and procedures to ensure key risks are mitigated and assist with ongoing corporate governance review. 

Resilient, pragmatic, and self-motivated, you will have an analytical and creative approach, with strong oral and written interpersonal skills. You will be an adaptable, credible influencer with excellent risk problem solving. 

Please include a CV and cover letter.

It is essential that in your written application you give evidence of examples of proven experience against each of the selection criteria listed in Part One of the person specification. These responses will be developed and discussed with those candidates invited for interview, together with the other criteria listed in Part Two. Ideally, the successful candidate will be a member of the Institute of Risk Management (or equivalent) or the Business Continuity Institute.

Reference:83268

Senior Scientific Manager (Software)

Salary range £45,556 to £55,123 per annum plus benefits 

We are recruiting for a development manager to lead an established team delivering software to support the cellular and genomics operational facilities at the Sanger Institute in Cambridge.

About you

You will be experienced with Agile development methods that foster a servant leadership culture. We typically use Scrum with certified Scrum Masters and Product Owners yet remain open and curious to evaluating other approaches that manage the uncertainty in delivering software.

You will be experienced modelling complex domains. You will be working closely with the development team, scientists in operations and senior partners to identify and design features that add new value to organisation. We typically use combinations of UML, user stories, mock-ups, informal whiteboarding and occasionally prototyping to build a shared understanding of what is required.

You will have a passion for process improvement. You will have experience participating in retrospectives, be comfortable using games beyond starfish to identify areas for improvement and celebrate great team working. You may have some experience with system thinking tools to engage with more complex situations.

You have a worldview of investing in the capability of the team through formal study, tactical project tasks and pairing to build team capacity. We guide and sponsor our developers though Open University degrees, MOOCS and on-site lectures to support their professional development.

You will have a technical background in software development. You will have experience with XP practices and familiarity with the tools and technologies a development team use to maintain the quality of a product over years of production use and change. You will be confident gaining practical knowledge in new technologies and what opportunities this could bring to the team.

You will have experience in mentoring or managing small-(2-3) to medium-(4-6) sized development teams. You should have demonstrable success in being part of a team that has learnt from failure and triumph. You may be an experienced manager or a senior developer wanting to step into management

 Technologies

We use JavaScript, Ruby, Python and Java with their associated web frameworks to build distributed concurrent systems, persisting data in relational & noSQL databases. Today these are MySQL, postgresql and Mongodb.

We favour RESTful web services and Message bus services to integrate our software. Software can be monoliths or microservices. We are increasing using private cloud technologies to deploy test and production systems to the Ubuntu O/S. Today RabbitMQ, Packer, Ansible, Terraform and Openstack support this strategy.

 What we can offer you

• Delivering opensource software to support science at scale at one of the world’s leading cellular & genomics institutes. Be part of some of the amazing advancements in science. You can find more on Git Hub (https://github.com/sanger) and the Sanger web site (https://www.sanger.ac.uk/news/archive )

• The autonomy to choose and refine the process you use to deliver software in collaboration with the team and the customer. Success will influence the technical strategy of the organisation.

• Face to face discussion and timely feedback with the domain experts, our scientists to regularly deliver software that improves our operational process.

• Access to our mentoring and coaching network to support your personal growth.

• A ringfenced training budget to invest in yourself and your team for training and conferences.

• An academic culture that is embracing commercial opportunities, informal dress code and excellent benefits package outlined below.

Reference:83243

Senior Software Developer - Human Cell Atlas & Teichmann Lab

Salary in the region of £40,850 - £49,428 (dependent on experience) plus excellent benefits

Fixed term for 3 years

Highly motivated Full-Stack Developer required to work on infrastructure for Big Data Genome analysis using OpenStack within the Teichmann laboratory at the Sanger Institute.

An exciting unique opportunity has become available to develop software infrastructure for Human Cell Atlas project (https://www.humancellatlas.org) which aims to increase our understanding of human body on a cellular level. The post holder will be part of the Teichmann group, working closely with colleagues in the core IT team of the Cellular Genetics division and the European Bioinformatics Institute.

Specifically, the post holder will contribute to developing a virtualised compute cloud infrastructure to allow our analysis workflows to be run in a distributed, adaptable and scalable environment. This position would suit a Software Developer who enjoys developing software solutions for large scale data analysis. The post holder will also apply these skills to building and improving the pipeline and portal development within the Teichmann/ Cellular Genetics team at the Sanger Institute.

We are looking for an individual who enjoys working in a multi-disciplinary team environment to help solve complex IT issues which will ultimately aid our understanding of the human body on a cellular level.

Reference:83276

Senior Web Developer - COSMIC

Salary in the region of £40,850 - £49,428 (dependent on experience) plus excellent benefits

Permanent / Open Contract

A revolution is underway in health informatics, with genetics increasingly important in understanding human health and disease. COSMIC (http://cancer.sanger.ac.uk/), a database of genetic mutations in cancer, is a major resource in cancer research, used by over 3000 scientists every day across the informatics, diagnostic and pharmaceutical industries. We are expanding rapidly and developing a range of new services to support multiple academic and industrial research efforts.

As a Senior Web Developer with COSMIC, you will be at the heart of our development efforts in this fast-moving discipline. Working closely with our scientists, bioinformaticians and web developers, you will play an important role in improving the ways in which we curate, analyse and display information. You will help to ensure that COSMIC remains a world-leading resource for scientists researching new approaches to understanding and treating cancer.

We are in the process of large-scale redevelopment of the COSMIC database, APIs, internal tooling, and external web app. This presents a unique opportunity for a talented full-stack developer to truly make their mark, working within the COSMIC web team, with developers and our UX lead, to build the new COSMIC platform.

While we are keen to find a developer with practical experience of modern JavaScript web apps, we recognise that many of the technologies we're using are only just reaching maturity. So, if you're passionate about using latest technologies but haven't got years of experience, we'd still love to hear from you.

We are open to a range of flexible working options including part-time or full-time employment as well as flexible hours.

Your qualities:

• A passion for writing clear, concise, and well-tested code
• Excellent written and spoken communication skills
• Collaborative and proactive ethos

What you will be doing:

We’re just beginning to rebuild our internal and external web services. While the initial designs are in place, we’re keen to incorporate intelligent suggestions from smart individuals to help produce the best system we can. We’re eager to use the right tool for the job and if you think a different language, framework or stack will give us a better end product, we’re all ears.

Reference:83270

Senior Web Developer - Cellular genetics informatics

Salary in the region of £40,850 - £49,428 (dependent on experience) plus excellent benefits

Permanent/ Open Contract

We are looking for a Senior Web Developer to join our Informatics team (https://www.sanger.ac.uk/science/groups/cellular-genetics-informatics). We are part of the Cellular Genetics programme which uses state of the art experimentation and computational tools to understand the biology of cells. Our team develops infrastructure for efficient data storage, access and analysis that supports the programme's research goals.

In this role you will develop and maintain infrastructure and visualization code for the Cellular Genetics programme’s needs. This will include creating user-friendly web portals for the researchers to access their data (both sequencing and imaging data), integrating automated execution of the analysis pipelines from the front end and visualisation of the results in the most convenient way. You will also be involved in working on the web interface for the Human Cell Atlas project https://www.humancellatlas.org/, in collaboration with the European Bioinformatics Institute) and develop web interfaces for specific research projects. Your role will be very collaborative and include a lot of interaction with both research scientists and the software team.

You will have access to Sanger's elite computational resources, including an OpenStack private cloud, an LSF computational cluster and many petabytes of high-speed distributed file systems and object stores.

We support recent graduates or current students in their final year to apply, although it is strongly desirable that you have relevant development experience outside of coursework (e.g. active participation in open source projects or the pursuit of personal coding projects). 

Reference:83257

Staff Scientist or Postdoctoral Fellow - Cancer Microbiota Interactions

Staff Scientist £36,373 - £44,011 or Postdoctoral Fellow £31,503 - £38,755  –Cancer-Microbiota Interactions plus excellent benefits

We are seeking a talented, motivated and experienced Staff Scientist or Postdoctoral Fellow to work at the Wellcome Sanger Institute on immune system-microbiota interactions under the leadership of Dr Trevor Lawley (www.lawleylab.com) and Dr David Adams (http://www.sanger.ac.uk/people/directory/adams-david).  We are expanding our germ free/gnotobiotic capabilities and are looking for a Scientist to lead the development of mouse models to understand how the human microbiota influences health and immunity. This position would be ideal for someone who recently completed postdoctoral training and has a strong background in mouse biology with a focus on such areas as immunology, metabolism, cancer biology or vaccinology.

This is an exciting opportunity for the successful candidate to join a dynamic team investigating the role of the microbiota in a variety of diseases, such as infections, cancers and immunotherapy using clinical samples, genomics, microbiology and model organisms. There is a strong translational focus with the goal of developing novel, microbiome-based diagnostics and therapeutics.

The successful applicant will have experience in designing and performing mouse experiments and analysis of the immune system using approaches such as flow-cytometry, transcriptomics and immunophenotyping to identify human commensal bacteria with immunomodulatory properties.  The post-holder will be part of a multidisciplinary, collaborative team and will be expected to work closely with existing team members to accomplish scientific objectives and proactively identify, establish and develop new collaborations and drive publications.

**please note: discussions will take place during the interview process as to which role profile you are being considered for.

Reference:83287

Stores Assistant

Salary in the region of £19,500 per annum, plus benefits 

We have a new opportunity for a Stores Assistant to join our skilled and knowledgeable team.

You will work on a 7 week rota system which assigns individuals to specific stores tasks for a week at a time and you will be trained across all of these tasks.

Our main areas of responsibility is to process deliveries for our customers through Goods in a timely fashion and to provide portering services to support the scientific community and other service departments.

• Process consumables on behalf of Genome Research Limited (GRL)
• Provide inventory held lab consumables for products that are high value, high usage and critical to pipeline teams
• Provide a daily portering service whereby all deliveries and requests for inventory are dropped at their delivery points in line with our same day, next day service level
• To respond and resolve delivery queries and emails in a timely manner
• To provide excellent customer service and logistical support to our customers

We operates a counter service 5 days a week; we provide a shop front for customers to collect their perishable deliveries, samples, work related documents and personal deliveries. Customers can also make urgent requests of stocked products, product or order enquiries at the counter during our opening times.

• You will ensure that our service levels are maintained to the highest standard and covered at all times.
• adhere to health and safety requirements and following standard operating procedures to provide an effective high quality customer focused stores service to agreed operating standards.

On the job training and support will be provided by an allocated mentor within the team. 

Reference:83280

Technical Innovator

Salary range and grade depending on skills and experience, both include benefits package

£37,739 to £45,664 - Grade 2

£47,773 to £57,806 - Grade 1

We are seeking to appoint a visionary computer architecture researcher to join our IT team in the role of Technical Innovator. In this unique, exciting and forward-thinking role you will be responsible for defining the future of our hardware and software solutions within the Sanger IT team, providing the opportunity to shape our organisation and Campus, making the huge scale computation challenges of tomorrow possible.

The Sanger Institute is a world leader in bioinformatics research for the benefit of human health. Specifically, our scientific niche is in large-scale, high-throughput biology, often incorporating systematic genome-wide screens. These are enabled by major data generation platforms in DNA sequencing, cellular genetics and mouse genetics with an accompanying large IT platform supporting computational data analysis.

To support such a vibrant, wide-ranging and creative research community, the Sanger Institute has one of the world’s largest life science IT facilities. Our facilities currently provide research groups with HPC clusters that deliver more than 20,000 compute cores, 15 PB of high performance Lustre file systems and data repositories exceeding 16PB.

The recent addition of a Flexible Compute Environment, based on OpenStack and 100GB/s software defined networking, exceeds 6000 further CPU’s and provides 1PB of high performance object storage to our customers. This new environment provides exciting opportunities to our research community both for collaboration and to embrace otherwise disruptive technologies as they come to market.

Such flexibility is key to our being able to adapt to the rapidly developing requirements of our scientific environment. Remaining at the leading edge of technology will be key to our IT strategy over the forthcoming years.

We are therefore delighted to announce that we are looking for an enthusiastic individual to compliment our existing IT staff. This exciting role is to look 5+ years ahead to what may be possible, rather than technology that is available today. You will evaluate how it aligns with our developing scientific challenges and how we can further engage with our strategic commercial and scientific IT partners to develop the solutions that we will need in the future.

For such a blue-sky research position, you should possess a mixture of talents and qualifications, and will be able to demonstrate:

• A strong and creative problem-solving mentality.
• An open and enquiring approach to IT, its challenges and how to overcome them.
• Highly self-motivated and with a will to share and disseminate information
• An ability to present new ideas and opportunities to a wider audience of both highly technical and non-technical audiences
• Provide contributions to wider audiences through peer review papers and conference presentations and posters.
• The proven ability to rapidly learn and evaluate new methods and tools
• Excellent written, verbal and numerical skills.
• Forward and independent thinking!

We believe that this post would be ideally suited to someone with a high degree in a computation or mathematic or scientific background. Specific knowledge of cloud or HPC technologies is desirable but a deep understanding and the implementation of today’s IT technologies, such as machine learning and computation approaches is more important.

This is a fantastic opportunity to not just join a world leading genetics research institute but also to help shape its IT future!

Reference:83239