Advanced Research Assistant
We are seeking an enthusiastic and motivated research assistant to provide experimental, scientific and operational support to the Cvejic Lab. The Cvejic Lab is a core part of the Open Targets consortium (https://www.opentargets.org/), a collaboration between world-leading experts from academia and industry that fosters research across multiple disease areas including neurodegeneration, oncology, and immunology.
About the Role:
We are seeking an enthusiastic Research Assistant to carry out both routine and more bespoke laboratory protocols and procedures. The research focuses on the regulation of haematopoiesis in homeostasis and disease. You will work as part of the team to provide laboratory support for the lab members. You will be working with a number of molecular biology techniques, in particular histological techniques, single cell transcriptomics and in vitro cell culture. You will be able to use your skills and experience to troubleshoot and innovate where required. Excellent verbal and email communication are essential to keep both the team and senior staff fully appraised of progress.
As a member of the Cvejic Lab, you will work closely with other members of the team to facilitate single-cell research to the Cvejic Lab and generate experimental evidence to meet our project aims.
You will mainly perform histological procedures such as fixation, embedding, sectioning and staining of human samples for downstream analysis. Furthermore, you will often assist with processing human samples for single-cell RNA sequencing, multiome, spatial transcriptomics and in vitro assays. You will have the opportunity to learn and utilise state-of-the-art phenotyping methodologies, such as scRNAseq, scATACseq, FACS and high-content imaging.
The position is initially funded for 24 months with the possibility for extension. This role will be based for the majority of the time in the Cvejic Lab at the Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge.
- Degree in Molecular Biology/Cellular Biology/Biomedical Science or a closely related discipline.
- Extensive laboratory experience in basic molecular biology techniques (qPCR, PCR, nucleic acid extraction and purification, gel electrophoresis).
- Experience with histology procedures (fixation of tissues, embedding, sectioning of paraffin and frozen tissues) and staining of tissues (e.g. H&E, immunohistochemistry (IHC)).
- Knowledge and practical experience with cell culture.
- Ability to use initiative, troubleshoot and work independently on agreed tasks.
- Capable of working to a schedule and delivery of a variety of projects simultaneously.
- Ability to maintain a sterile environment when handling tissue samples.
- Detail-oriented and highly organised, including keeping excellent scientific records.
Please apply with your CV and a cover letter describing how you meet the criteria for the role. Interviews may take place on a rolling basis before the application deadline, therefore we encourage you to apply early to avoid disappointment. We welcome applications from a broad range of candidates and are committed to creating a diverse and inclusive work place.
Informal inquiries can be made directly to Ana Cvejic.
The Wellcome Sanger Institute is a proud signatory of the Technician Commitment to play our part in valuing, developing and rewarding our highly skilled technical employees.
About Open Targets
Open Targets is a pioneering public-private partnership between European Bioinformatics Institute (EMBL-EBI), GlaxoSmithKline (GSK), the Wellcome Sanger Institute (Sanger), Sanofi and Bristol Meyers Squibb (BMS), located at the Wellcome Genome Campus in Hinxton, near Cambridge, UK.
Open Targets brings together expertise from five complementary institutions to generate evidence on the biological validity of therapeutic targets and provide an initial assessment of the likely effectiveness of pharmacological intervention on these targets, using genome-scale experiments and analysis. Open Targets aims to provide an R&D framework that applies to all aspects of human disease to improve the success rate of discovering new medicines and share data openly in the interest of accelerating drug discovery.