Advanced Research Assistant - Open Targets

Advanced Research Assistant - Open Targets

Advanced Research Assistant - Open Targets

We are looking for a highly motivated Advanced Research Assistant to join a collaborative, large-scale project that aims to understand the cellular basis of neurodevelopmental disorders. The prospective candidate will be involved in studying how mutations in chromatin modifying enzymes affect neuronal development and cause disease. The primary goal of the work is to culture and differentiate human iPS cells with and without mutations to neuronal cell types, and profile the cells with a range of cellular and genomic assays. This is an exciting opportunity to be engaged in all aspects of a cutting-edge research project, from planning and pilot work to data generation and novel discoveries.

The project forms part of the Open Targets collaboration ( and provides a unique opportunity to deliver translational science together with industry partners including GSK, Celgene, Sanofi, and Takeda. The prospective candidate will work at the Wellcome Sanger Institute with Dr. Helena Kilpinen and the Cellular Generation and Phenotyping (CGaP) core facility, collaborating closely with the Hurles group and other members of the Open Targets team.

Salary per annum
26,960 to 32,622
Full Time or Part Time
Full Time
Contract Type
Fixed Term
Contract Length
2 years with the possibility of extension
Job Reference

Essential Skills

  • Degree in Biological Sciences, or equivalent qualification
  • Previous work experience in a molecular biology laboratory
  • Excellent laboratory practice and attention to detail
  • Ability to work to a schedule and successfully manage a project
  • Ability to keep good up-to-date records
  • Excellent organisational and communication skills
  • Ability to work independently and within a group but be able to recognise when to seek help
  • Ability to test, implement, and troubleshoot new techniques and protocols
  • Extensive experience with mammalian cell culture
  • Experience with core molecular biology techniques, including RT & qPCR, and RNA/DNA extraction
  • Experience with core cell biology techniques, including immunofluorescence and microscopy
  • Excellent sample management for high-throughput assays; tracking, labelling and storage of samples

Ideal Skills

  • Experience in human iPS culture and differentiation
  • Experience with neuronal cell types
  • Experience with protocols relevant to genomics of gene expression and gene regulation including chromatin immunoprecipitation (ChIP), and ATAC-seq
  • Knowledge of single-cell sequencing technologies

Other information

Open Targets is a pioneering public-private partnership between EMBL-EBI (European Bioinformatics Institute), GlaxoSmithKline (GSK), the Wellcome Sanger Institute (Sanger), Celgene, Sanofi and Takeda, located on the Wellcome Genome Campus in Hinxton, near Cambridge, UK.

Open Targets brings together expertise from six complementary institutions to generate evidence on the biological validity of therapeutic targets and provide an initial assessment of the likely effectiveness of pharmacological intervention on these targets, using genome-scale experiments and analysis. Open Targets aims to provide an R&D framework that applies to all aspects of human disease, to improve the success rate for discovering new medicines and share its data openly in the interests of accelerating drug discovery.

Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.

Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:

  • Defined Contribution Pension Scheme and Life Assurance
  • Group Income Protection
  • Private Health Insurance
  • 25 days annual leave, increasing by one day a year to a maximum of 30
  • Family friendly environment including options for flexible and part-time working, a childcare voucher scheme, Campus Nursery and Summer holiday club
  • Two days paid Employee Volunteering Leave a year
  • Employee Discount Scheme
  • Campus Gym, tennis courts and sports hall plus a range of dining facilities
  • Active Campus Sports and Social Club
  • Free Campus Bus Service

Genome Research Limited hold an Athena SWAN Bronze Award and will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

Please include a covering letter with your application describing how you meet the essential criteria for the role and why you are interested in the position. 

Closing date: 22 September 2019