Faculty Positions - Human Genetics
The Wellcome Sanger Institute is seeking an exceptional mid to late career stage scientist to join its Core Faculty to lead a research team in Human Genetics and contribute to the Institute’s scientific portfolio. Positions carry a significant core package of salaries and support backed by rewarding and flexible employment terms including excellent benefits and relocation support.
Faculty positions in Human Genetics
The Human Genetics Programme is driving a step-change in our understanding of genetic causes and biological mechanisms of disease susceptibility and progression. Our research integrates population-scale genetics, longitudinal clinical data, and large-scale genetic perturbation studies in cellular model systems. Current faculty research focuses on developmental disorders and diseases of the blood and immune system, and we aim to transform the clinical impact of human genomic data in the diseases we study. We are developing a comprehensive, predictive understanding of the genetics of severe developmental disorders at nucleotide resolution, which will provide the evidence base to diagnose these lifelong conditions more accurately, more rapidly and earlier in life. We are determining the molecular mechanisms that underpin genetic associations with diseases and traits involving blood and immune cells, including both disease susceptibility and disease progression, to empower the development of new drugs and the implementation of effective stratified and preventative medicine.
For more information about the programme and its team, visit www.sanger.ac.uk/programme/human-genetics/
Support available in Human Genetics
We have an established operational infrastructure within the Human Genetics Programme to support the research of the Human Genetics faculty. The Operational teams, led by the Head of Human Genetics Operations, are structured into two primary areas:
These teams work collaboratively to deliver a backbone of operational support to the Human Genetics Programme Faculty, enabling them to focus on delivering their cutting-edge research. The administration team includes PA support for all faculty and assistance in managing complex large-scale projects. The informatics team develops, maintains and operates informatics pipelines, data and software resources and analytical infrastructures, to support large-scale computational analyses.
The operations teams also provide a key interface with central Institute functions including the core Sanger pipelines within Scientific Operations and the Management Operations teams. The Administration team provides day-to-day administration including core and grant funding finance management, identifying third party funding opportunities, and ensuring regulatory and legal compliance in collaboration with central Institute teams.
Roles available in Human Genetics
The Wellcome Sanger Institute is seeking a Group Leader 3 (GL3) Faculty member to join as a Core Faculty member leading a research team in Human Genetics, and contributing to the Institute’s scientific portfolio.
GL3 Faculty members embody the long term intellectual foundations of the Institute’s science, run internationally recognized, successful independent research groups and demonstrate significant internal and external leadership, and are normally supported with resources for 6 FTE plus consumables. They are expected to have a substantial record of research achievement and be scientific leaders at the forefront of their own fields. Within the Institute they lead and develop Sanger’s long term research strategy and play a central role in the development of the five year research plans.
Positions carry a significant core package of salaries and support, which are backed by rewarding and flexible employment terms including excellent benefits and relocation support. Our exceptional core funding enables Faculty to focus their energy on science.
GL3 Faculty positions are the equivalent of a Professor at a UK university or a Full Professor at a US University. These positions provide significant internal and external leadership, scientifically and institutionally and are designed to lead and develop Sanger’s long term research strategy and play a central role in the development of the Institute’s five year research plans. Our GL3 Faculty have an outstanding international research profile and reputation and are leaders of a major research field or group. They provide strategic research leadership, making a significant contribution to the delivery, coherence and continuous development of the Programme to become a world-class research unit. They are thought-leaders used to contributing to peer review bodies/committees, professional organisations, learned societies, Government committees etc and will be experienced in leading a team including mentoring and motivation of colleagues and line reports with evidence of impact. These positions have a rolling tenure but have a review every six years.
For further information about our Faculty Model, please visit https://www.sanger.ac.uk/about/careers/faculty-recruitment
Opportunity and selection criteria
Human Genetics seeks a GL3 Faculty member with research interests in any (or a combination) of the following:
Human genetics at the cellular level
Blood and immune-mediated diseases
Developmental disorders (including CNS disorders or other organ systems, e.g. congenital heart defects)
Human genetics at the cellular level could involve natural or engineered genetic variation, primary cells or cell-lines. Examples of relevant research programmes could include:
delineating the genetic determinants of cellular phenotypes, applying cellular genomic technologies to investigate genetic associations with common diseases, rare disorders or quantitative traits,
using genome editing, or multiplexed assays of variant effect, to determine the functional impact of genetic variation
We strongly encourage potential applicants to interpret this description broadly. We will focus on scientific achievement, experience, leadership and personal suitability in line with our core behavioural competencies: collaboration, communication, leadership, integrity, results-driven, and innovation.
About the Institute
The Wellcome Sanger Institute is a world-leading genomics research centre, based on the Wellcome Genome Campus, arguably the largest single-site community worldwide of expertise in Genomes and BioData. We undertake large-scale research that forms the foundations of knowledge in biology and medicine. We are open and collaborative; our data, results, tools and technologies are shared across the globe to advance science.
Our ambition is vast – we take on projects that are not possible anywhere else.
The high-throughput, large-scale biological research undertaken at the Institute is a central defining characteristic distinguishing our science from that of most research institutes and universities.
It’s an exciting time to join the Sanger Institute as we recruit exceptional scientists in all five of our research programmes: Cancer, Ageing and Somatic Mutation, Cellular Genetics, Human Genetics, Parasites and Microbes, and Tree of Life, spanning all levels of our Faculty model. You’ll join a unique, vibrant and interactive research environment with an internationally outstanding genomic research centre at the heart, as a Core Faculty member to lead a research team in one of the five programmes, and contribute to the Institute’s scientific portfolio.
Applications should be accompanied by:
- Curriculum vitae, complete list of publications and details of three referees;
- A two-page cover letter summarising:
- your scientific and leadership achievements to date,
- your contribution to the wider research community and society, you may wish to include diversity and inclusion initiatives and public engagement events.
- which Faculty level you wish to be considered for and why; and
A three-page outline of future research plans indicating how these fit with the research areas, the chosen Programme, and the wider Institute. Please include a short abstract at the start of this document (no more than 250 words) summarising your plans.
We understand that the global impact of COVID-19 and the lockdown period may have negatively impacted your research, as you may have had to adjust your working pattern, had reduced access to research facilities, and/or taken on additional responsibilities, such as childcare or caring for others. As part of our recruitment process we would like to better understand your experiences and how COVID-19 has impacted on your research progress and any research outputs, so that we can take this into consideration when we review your application. Please use the application form to tell us more.
Interviews will be held in January/February 2022
For an informal conversation about the positions, before submitting an application,
please contact Dr Matthew Hurles. Further information regarding the Institutes science, Faculty and building a career at the Institute can be found at Our Science, Faculty teams and Faculty careers.
If you have any questions about the application process or have any informal enquiries about working at and moving to the Sanger Institute, please contact Sam Bowker, Head of Recruitment and Immigration.
Our global reputation for excellence is strengthened by our commitment to developing and maintaining a positive, fair and healthy working environment – our Equality, Diversity and Inclusion (EDI) Programme is about valuing our people and supporting them to be their best. Our leaders play a key role in nurturing a positive and inclusive culture where everyone can thrive and diversity is celebrated.
We provide a range of progressive policies which support everyone to achieve a positive work life balance. Our innovative and flexible approach within our scientific leadership model for Faculty who have taken parental leave, includes extending tenure by up to an additional 18 months to support the transition back to research; access to a flexible returners’ grant scheme when returning from parental leave and access to a carers’ grant that offers financial support. In considering candidates for a Faculty position, if an absence or career break may have impacted on scientific outputs, this will be taken into consideration.
We strive to be an inclusive and dynamic research environment, and encourage applications from those wishing to work flexibly to meet personal responsibilities. We are committed to providing equal opportunities for everyone, regardless of their background. Acknowledging that people from certain backgrounds are under-represented at this level, we are especially interested in receiving applications from women and people from Black, Asian and Minority Ethnic backgrounds.