Postdoctoral Fellow - Experimental Data Generation
Salary range £31,897 - £39,240 (dependent on experience) plus excellent benefits
Fixed term for 3 years
A position is now available for a highly motivated Postdoctoral Fellow to join the research group of Dr. Ana Cvejic, Dr Peter Campbell and Open Targets partners at the Wellcome Sanger Institute (WSI).
Open Targets aims to provide evidence on the biological validity of therapeutic targets and provide an initial assessment of the likely effectiveness of pharmacological intervention on these targets, using genome-scale experiments and analysis. This pioneering public-private partnership between Sanofi, Celgene, EMBL-EBI, GlaxoSmithKline, Takeda, and the Wellcome Sanger Institute, aims to provide a R&D framework that applies to all aspects of human disease, and to share its data openly with the scientific community (http://www.opentargets.org).
The project will combine state-of-the-art single-cell experimental data generation with computational analysis using novel methods to reveal the full spectrum of transcriptional and epigenetic changes that are associated with myeloid progenitors’ migration and differentiation at the tumour sites.
You will have a PhD with significant experience in molecular and cell biology. Experience in CRISPR screening will be highly desirable. Knowledge or interest in the field of haematology, cancer biology and inflammation would be highly advantageous. You will be able to demonstrate independent, critical thinking, will be passionate about science, and keen to learn and improve skills in an outstanding research environment.
- PhD in immunology, cancer biology, biological sciences (or similar)
- Extensive experience in a research environment with a well-established publication track record
- Demonstrable ability to lead the projects
- Highly organised
- Ability to work independently and as a part of the team
- Experience in flow cytometry and cell culture
- Experience in working with patient-derived material
- Experience with CRISPR screening
Open Targets is a pioneering public-private initiative between GlaxoSmithKline (GSK), Takeda, Celgene, Sanofi, EMBL-EBI (European Bioinformatics Institute) and the WSI (Wellcome Sanger Institute), located on the Wellcome Genome Campus in Hinxton, near Cambridge, UK.
Open Targets aims to generate evidence on the biological validity of therapeutic targets and provide an initial assessment of the likely effectiveness of pharmacological intervention on these targets, using genome-scale experiments and analysis. Open Targets aims to provide an R&D framework that applies to all aspects of human disease, to improve the success rate for discovering new medicines and share its data openly in the interests of accelerating drug discovery.
Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.
Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:
- Defined Contribution Pension Scheme and Life Assurance
- Group Income Protection
- Private Health Insurance
- 25 days annual leave, increasing by one day a year to a maximum of 30
- Family friendly environment including options for flexible and part-time working, a childcare voucher scheme and Campus Nursery
- Two days paid Employee Volunteering Leave a year
- Employee Discount Scheme
- Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities
- Active Campus Sports and Social Club
- Free Campus Bus Service
Genome Research Limited hold an Athena SWAN Bronze Award and will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.
Please include a covering letter and CV with your application.
Closing date: 2nd June 2019