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Postdoctoral Fellow - Single cell genomics of disease

Salary range: £31,897-£39,986 per annum depending on experience plus excellent benefits.

Fixed Term Contract for 3 Years.

Applications are invited for a 3-year Postdoctoral Fellowship within the Genomics of Inflammation and Immunity group at the Wellcome Sanger Institute (WSI), headed by Dr. Carl Anderson ( Our group uses large-scale genetic and genomic data to understand the biological basis of inflammatory bowel disease (IBD) risk and progression. The ultimate goal of our IBD research is to identify new drug targets for the disease, and ascertain which individuals should be prescribed a given drug.

We have been awarded funding from the Crohn’s Colitis Foundation (CCF) to generate single-cell transcriptomic data from intestinal biopsies obtained from 160 IBD patients undergoing colonoscopy. All individuals will also be genotyped, with the goal of combining these datasets to map eQTLs across the more than forty different cell-types in the inflamed gut. The results from these analyses will then be combined with our detailed maps of IBD risk loci (and other gastrointestinal diseases) to identify genes that are dysregulated to bring about disease. The ultimate goal of the research is thus to improve our basic knowledge of IBD pathogenesis and identify novel candidate drug targets for treating disease.

You will use your established expertise in single-cell genomics and/or QTL mapping to lead the analysis and ensure that the project delivers on its ambitious goals. You will take intellectual ownership of the project and think broadly about questions that can be addressed using the data. You will collaborate closely with other members of the Anderson Lab working on a similar project to build a single-cell derived map of gut eQTLs from biopsies ascertained from 300 healthy individuals. As such, this project will suit a self-motivated individual with good communication skills who is looking to make a personal contribution to genomic research.

Job Reference

Essential Skills

  • Ability to work with others in a collegiate and collaborative environment.
  • Motivation and ambition to make a personal contribution to genomic research
  • A PhD in a relevant subject (genetics, functional genomics, computer science, maths)
  • Experience with large-scale computational analysis
  • Statistical/computational genetics skills and an analytical mindset
  • Previous experience with analysis of genotype, sequence or functional genomic data
  • Experience with computer programming & scripting
  • An attention to detail and a drive for rigor

Ideal Skills

  • A strong scientific publication record
  • An interest in understanding the biological basis of immune-mediated diseases

Other information

The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute. 

Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.

Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:

  • Defined Contribution Pension Scheme and Life Assurance
  • Group Income Protection
  • Private Health Insurance
  • 25 days annual leave, increasing by one day a year to a maximum of 30
  • Family friendly environment including options for flexible and part-time working, a childcare voucher scheme, Campus Nursery and Summer holiday club
  • Two days paid Employee Volunteering Leave a year
  • Employee Discount Scheme
  • Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities
  • Active Campus Sports and Social Club
  • Free Campus Bus Service

Genome Research Limited hold an Athena SWAN Bronze Award and will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

Please include a CV and a Cover Letter.

Closing date: 3th August 2019, however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline.