Postdoctoral Fellow - Tumour Cell Immune Response CRISPR

Open Targets

Salary range £31,897 - £39,240 (dependent on experience) plus excellent benefits

Fixed Term for 3 Years

The Garnett lab is seeking a postdoctoral scientist to develop CRISPR base-editing screens to investigate tumour cell mediators of immune signalling and response to immunotherapy. 

Immunotherapies against PD1 and CTLA-4 are effective for the treatment of multiple tumour types. However, immune checkpoint blockade is not effective for all cancers or molecular subtypes, and the range and duration of clinical responses remains poorly understood. The aim of this project is to develop CRISPR base-editing screens in cancer cells to characterize regulation of tumour cell mediated immune signaling to understand mechanisms of resistance to checkpoint therapies. 

You will work as part of multidisciplinary and collaborative team. The project forms part of the Open Targets collaboration, a private-public partnership between academia and industry, including the Sanger Institute, the Netherlands Cancer Institute (PI: Dr. Emile Voest, MD PhD), and pharmaceutical companies as part of the Open Targets community.

You will have a background in immunology and cancer biology, an in-depth knowledge and experience of CRISPR-based screening methods, and strong molecular biology skills. You should be a team player, have excellent organizational skills, and strong verbal and written communications skills, as well as a proven track record of productivity. Postdoctoral fellows are typically in their first or second postdoctoral position as part of a period of early career research training. The position is initially for a 3-year fixed term.  

Further details of the Garnett lab (https://www.sanger.ac.uk/science/groups/garnett-group), Sanger Institute CRISPR R&D team (https://www.sanger.ac.uk/science/groups/gene-editing-and-cellular-research-and-development), (Voest lab (https://www.nki.nl/divisions/molecular-oncology-immunology/voest-e-group/) and Open Targets (https://www.opentargets.org/) are available at the provided links.

Job Reference
83479

Essential Skills

  • PhD in immunology, cancer biology, molecular biology, or related discipline
  • In depth knowledge of CRISPR technology, especially base editing
  • Excellent communication, organisational and presentation skills
  • Excellent problem solving and troubleshooting skills
  • Ability to work independently and organize own workload
  • Ability to organize, plan and prioritize tasks or projects
  • Demonstrated ability to network and build relationships
  • Ability to communicate ideas and results effectively

Ideal Skills

  • Experience using CRISPR base-editing or related CRISPR method
  • Knowledge of cancer immunology
  • Knowledge of cancer biology and therapeutics

Other information

Open Targets is a pioneering public-private partnership between EMBL-EBI (European Bioinformatics Institute), GlaxoSmithKline (GSK), the Wellcome Sanger Institute (Sanger), Celgene, Sanofi and Takeda, located on the Wellcome Genome Campus in Hinxton, near Cambridge, UK.

Open Targets brings together expertise from six complementary institutions to generate evidence on the biological validity of therapeutic targets and provide an initial assessment of the likely effectiveness of pharmacological intervention on these targets, using genome-scale experiments and analysis. Open Targets aims to provide an R&D framework that applies to all aspects of human disease, to improve the success rate for discovering new medicines and share its data openly in the interests of accelerating drug discovery.

Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.

Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:

  • Defined Contribution Pension Scheme and Life Assurance
  • Group Income Protection
  • Private Health Insurance
  • 25 days annual leave, increasing by one day a year to a maximum of 30
  • Family friendly environment including options for flexible and part-time working, a childcare voucher scheme and Campus Nursery
  • Two days paid Employee Volunteering Leave a year
  • Employee Discount Scheme
  • Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities
  • Active Campus Sports and Social Club
  • Free Campus Bus Service

Genome Research Limited hold an Athena SWAN Bronze Award and will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

Please include a covering letter and CV with your application.

Closing date: 9th June 2019