Research Assistant / Advanced Research Assistant

Here at the world-famous and internationally respected Wellcome Sanger Institute, we have an exciting opportunity for a number of talented Research Assistants and Advanced Research Assistants to join the Cellular Operations (CellOps) division.

The roles will be part of our Cellular Screening and Cellular Generation teams to perform high-quality cell biology work across one of our of key projects.

About the role

As an Research Assistant or Advanced Research Assistant within these projects, you will be involved in one of the following areas:


  • Derivation of new 3D organoid models, their expansion and cryopreservation, plus ensuring Quality Controls are met.
  • Developing models from a variety of tissues including human tumour samples.

CRISPR screening

  • Perform large-scale CRISPR-Cas9 screens on human cancer and iPSC lines to investigate gene essentiality
  • Analyse the screens using quality control assays such as flow cytometry and viability assays

iPSC differentiation

  • Expansion, banking and differentiation of iPSCs into neural stem cells using both wild type and knock out iPSCs
  • Perform and analyse iPSCs and NSCs using ICC quality control assays

About you

  • A proactive, self-organising individual, enthusiastic about the development of cell biology models and techniques.
  • Capable of carrying out routine technical tasks independently.
  • Able to excel at working in diverse, collaborative teams in a matrix-managed setting. We function in a collaborative environment spanning across multiple Faculty and core facility groups.

About the research

We are a core research group, responsible for providing molecular and cell biology resource and expertise to the wider Institute. We do this by running multiple, diverse, high-throughput projects for Faculty teams across the Sanger Institute. Our current portfolio of projects includes the generation of CRISPR-edited cells, genome wide CRISPR screens of cancer cells, differentiation of iPSC toward neuronal lineages, organoid derivation, and Spatial Genomics.

As signatories of the Technician Commitment, we value the personal growth and recognition of our dedicated staff. As part of this role, you will be actively encouraged to take part in learning and development opportunities, public engagement and department-wide initiatives. We have a number of working groups that you may join, such as the communication group, which aims to effectively promote our work across the Institute and externally. In addition, we are driven by a culture of inclusion, which means you will be fully supported to engage with the various staff networks or take part in any Institute-wide initiative.

Further information about Cellular Operations, and the institute’s involvement in the Technician Commitment, can be found on our website:

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Athena Swan
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Working Families
Salary per annum
20,500 to 34,000
Full Time, Part Time, Flexible Working
Full Time/ Part Time/Flexible Working
Contract Type
Closing Date
19 August 2022
Job Reference

Essential Skills

  • Degree in Biological Sciences, or equivalent experience
  • Experience in a life science laboratory
  • Good knowledge of cell culture techniques
  • High attention to detail and good record keeping
  • Proven ability to be able to organise and schedule their own work
  • Excellent written and oral communication skills
  • Experience collaborating with others and effectively working in teams

Advanced Research Assistant only:

  • Extensive mammalian cell culture experience
  • Experience of running cell based assays or antibody staining techniques
  • Experience in troubleshooting and protocol development
  • Excellent organisational skills, able to multi-task and prioritise effectively
  • Experience training others in scientific techniques

Other information

Applications will be reviewed on an ongoing basis and the role may close when a successful appointment has been made