Senior Bioinformatician - Immune Mediated Diseases

The Opportunity:

We are looking for a senior bioinformatician (data manager), who has experience of handling large genomic datasets, to look after our data repository. The work includes managing various data collections, performing data retrieval and pre-processing data for research projects, and developing tools and practices for data management and processing.

Our team and the role:

The Genomics of Inflammation and Immunity Group at the Wellcome Sanger Institute, led by Dr. Carl Anderson, is a diverse and multi-disciplinary team of statisticians, geneticists, immunologists, computer scientists and clinicians who work together to understand the genetics and genomics of immune-mediated disease (

You will play a central role in a substantial research programme using high-throughput genetics and genomics to further our biological understanding of immune-mediated diseases and, ultimately, identify new drug targets for these debilitating diseases. The team has complex genomic and phenotypic data on tens of thousands of patients and healthy individuals, and we are looking to recruit a Senior Bioinformatician to lead the integration and management of all genetic and phenotypic data in the group.

About you:

You will develop and establish best-practices for storage, backup, and organization of genetic (WGS, WES and genotyping array data), genomics (RNAseq and single cell expression data) and phenotypic data for thousands of participants. The work includes creating pipelines, in a high-performance computing environment, that implement these practices, including standardized quality control pipelines for ensuring data integrity. You will be responsible for ensuring that our data is uploaded to appropriate repositories, ensure data security, and handle queries from external users of our data. Similarly, you will drive the ascertainment of external datasets and ensure that these are documented and aligned appropriately to internal datasets.

You will also play a key role in selecting samples for whole exome sequencing, minimizing unwanted duplicates and ensuring that samples are tracked throughout their journey through the Institute’s core sequencing and informatics pipelines. You will contribute to standardizing and scaling analysis pipelines and to the writing of scientific research papers.

You will have a collaborative approach to research and take a full and active role in discussions, contributing both ideas and expertise as necessary.

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Athena Swan
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Technicians Commitment
Salary per annum
Full Time, Part Time, Flexible Working
Full Time/Flexible working considered
Contract Type
Fixed Term
Contract Length
3 Years
Job Reference

Essential Skills

Technical Skills:

  • A degree or equivalent experience in one of the following subjects: Bioinformatics, Biostatistics, Computer Science, Mathematics, Statistics, Life Sciences or equivalent experience 
  • Previous experience handling large-scale genetic/genomic data
  • Experience working with relational databases (i.e. MySQL) and good knowledge of programming languages to manipulate large datasets (Python, R) 
  • Experience working in a Unix environment 
  • Previous experience as a Data manager, or an equivalent coordination role 

 Behaviours and Competencies:

  • Strong organisational skills and ability to judge priorities 
  • Self-motivated, able to work independently and organise own workload 
  • Ability to work accurately, with attention to detail 
  • Ability to communicate effectively and work collaboratively with other team members and external collaborators

Ideal Skills

  • Knowledge of standards for exchange of human genetic, phenotypic and clinical data 
  • Experience of preparing data for analysis by others 
  • Experience in report writing and presentation skills 

Other information

 Application Process:

Please apply with your CV and a cover letter outlining your suitability for the role addressing the criteria set out above and in the job description.

This is a rolling advert, applications will be considered and interviews will take place on an ongoing basis and the role will close when successful appointment has been made.