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Senior Bioinformatician - Wormbase

Salary in the region of £36,737- £44,451 (dependent on experience) plus excellent benefits

Permanent/ Open Contract

The Parasite genomics team at the Wellcome Sanger Institute are seeking a talented Bioinformatician to develop WormBase ParaSite (, an integrated portal for parasitic worm genomics.

Parasitic worms are responsible for more than one billion human infections globally and have a devastating impact on livestock and agriculture. WormBase ParaSite facilitates new approaches to the study and control of parasitic worms by integrating, analysing and displaying genomic data for hundreds of species. At also serves as a foundation for comparative genomics, enabling deep explorations of genome evolution across all roundworms and flatworms and, more broadly, across other animal taxa.

You will work on a range of data analysis, data integration and community-engagement activities for WormBase ParaSite, and will also actively participate in the exciting next phase of development for the resource. The main areas of focus will be:

  • Customisation and deployment of annotation pipelines for parasitic worm genomes
  • Analysis, curation and integration of large-scale genomics data sets (e.g. studies of gene expression and genomic variation)
  • Community engagement, including presentations and training workshops at conferences

WormBase ParaSite is a sister project to the well-known WormBase ( and Ensembl ( projects. As well as working with genome scientists within the Parasite genomics team, you will also collaborate closely with WormBase and Ensembl staff at the neighbouring European Bioinformatics Institute (EMBL-EBI).

Job Reference

Essential Skills

  • Programming/scripting experience (e.g. Perl, Python)
  • Experience with relational databases (MySQL or Postgres)
  • Proficiency in Unix/Linux operating system
  • Excellent communication skills
  • Attention to detail


Ideal Skills

  • Bioinformatics experience at Masters or PhD level
  • Experience analysing functional genomics experiments (especially RNASeq)
  • Knowledge of parasitology, preferably helminths
  • Experience with genome annotation methodologies and pipelines
  • Experience with the Ensembl genomics infrastructure

Other information

The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute. 

Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.

Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:

  • Group Defined Contribution Pension Scheme and Life Assurance
  • Group Income Protection
  • Private Health Insurance
  • 25 days annual leave, increasing by one day a year to a maximum of 30
  • Family friendly environment including options for flexible and part-time working, a childcare voucher scheme, Campus Nursery and Summer holiday club
  • Two days paid Employee Volunteering Leave a year
  • Employee Discount Scheme
  • Campus Gym, tennis courts and sports hall plus a range of dining facilities
  • Active Campus Sports and Social Club
  • Free Campus Bus Service

Genome Research Limited hold an Athena SWAN Bronze Award and will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

Please include a covering letter and CV with your application. Closing date for applications: 28th June 2019