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Senior Staff Scientist - CRISPR screening and cellular modelling

Salary range; £44,159 to £53,432 per annum, plus benefits 

Part time and flexible applications considered equally with full time.

We are seeking an enthusiastic, motivated senior staff scientist to lead in the development of cutting-edge techniques for high throughput genetic screening and cellular phenotyping. You will work in the Cellular Operations division as part of the research and development team led by Dr Andrew Bassett, and be involved in shaping the scientific direction of this group.

The development of genome editing technologies such as CRISPR/Cas9 has allowed us to accurately model the genetic basis of many human diseases and enabled genome-wide genetic screens in human cellular systems. The Wellcome Sanger Institute has an exceptional background in human disease genetics, high throughput CRISPR screening and single cell biology. In close collaboration with other groups at the institute you will develop novel cutting-edge CRISPR screening techniques such as saturation mutagenesis, base editing, dual guide libraries and CRISPRa/i and couple these to complex phenotypic readouts such as single cell transcriptomics, spatial genomics or phenotypic assays of cellular function. You will also be involved in developing human cellular systems (e.g. hematopoietic stem cells), and differentiation protocols of iPSCs in both 2D and 3D (e.g. cortical organoids) to better model human disease states in vitro. The systems developed will be applied to probe the genetic basis of cellular function in health and disease and understand the underlying cell biology.

The cellular research and development team is interested in the development of genome editing techniques, cellular differentiation and cellular phenotyping systems, especially with respect to high-throughput investigation of gene and non-coding regulatory element function. The Wellcome Sanger Institute offers a world-class academic environment, access to cutting edge sequencing facilities and extensive expertise in genome analysis and human genetics.

For informal enquiries please contact Andrew Bassett at ab42@sanger.ac.uk

Job Reference
83494

Essential Skills

  • PhD and extensive postdoctoral experience in molecular biology, cell biology, genetics or related discipline or other equivalent experience.
  • Proven track record of publications.
  • Demonstrated ability to quickly learn, understand and implement new technologies.
  • An ability to develop novel techniques.
  • Significant practical experience using CRISPR technology in mammalian cell systems.
  • Extensive experience of molecular biology e.g. vector design and construction, high throughput sequencing library prep, etc.
  • Comprehensive, up to date and in depth understanding of CRISPR-based genetic screening, stem cell culture and differentiation, automation of cell culture, single cell transcriptomics and spatial genomics.
  • Proven practical experience in at least one or more of these five areas.
  • Self-motivated, ability to work independently and organise own workload.
  • An ability to lead and inspire others to achieve scientific projects.
  • Exceptional communication, organisational and presentation skills.
  • Strategic planning – an ability to create a vision and plan to achieve that vision.
  • Good at relationship building and able to influence, negotiate and persuade others.
  • Excellent collaborator.

Ideal Skills

  • Experience in supervising, training and teaching others.
  • Practical experience in gene editing in human ES or iPS cells.
  • Background in fluorescence imaging.

Other information

The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute. 

Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.

Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:

  • Defined Contribution Pension Scheme and Life Assurance
  • Group Income Protection
  • Private Health Insurance
  • 25 days annual leave, increasing by one day a year to a maximum of 30
  • Family friendly environment including options for flexible and part-time working, a childcare voucher scheme, Campus Nursery and Summer holiday club
  • Two days paid Employee Volunteering Leave a year
  • Employee Discount Scheme
  • Campus Gym, tennis courts, and sports hall plus a range of dining facilities
  • Active Campus Sports and Social Club
  • Free Campus Bus Service

Genome Research Limited hold an Athena SWAN Bronze Award and will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

Please include a covering letter and CV with your application. 

Closing date: 17th June 2019

Interviews expected to take place week commencing 24th June.