Advanced Job Search Results

Advanced Job Search Results

Here you can take a quick look at the current jobs on offer. There are three ways of doing this: you can select on date posted, select criteria for the type of job you are interested in using the checkboxes and/or the free text.

Junior Bioinformaticians - COSMIC

We are seeking to recruit two passionate Junior Bioinformaticians who can help to develop and maintain genomic annotation pipeline for the world’s key cancer genomics resource, in COSMIC (Catalogue of Somatic Mutations of Cancer).

About Us:

COSMIC is the key information source in global human cancer research. We exist to speed up the field of precision oncology so that every cancer journey can be tailored, accurate, and precise. We do this by streamlining and simplifying genomics data analysis for better prevention, diagnosis, and treatment research.

To achieve our vision, we're growing rapidly in content, scope and value. This role is due to the evolution and expansion of our massive biological datasets and products to enable this growth. We make a real difference to scientific research and to cancer patients around the world. Data is currently gathered from a variety of sources, from manual curation to structured repositories, and standardised into the COSMIC database before release via our analytic website. This genetic and genomic data is increasing in quantity and scope, its value is enhanced by analytic highlights, and this position will improve the handling, annotation, meaningful presentation and user access of this information. More specifically to this role, we provide excellent opportunities to apply best practises in software development, writing clean code, and taking a test-driven development approach.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323903/

Key Responsibilities:

  • You will be responsible for developing and maintaining an automated genomic annotation system and pipeline to handle high throughput cancer genetics datasets,
  • Support the development of data structures that will support future COSMIC databases, downloads and websites.
  • You will support developing software and analytical tools across large and complex biological datasets, ensuring throughput and quality. 

About You:

This role would suit somebody with bioinformatics knowledge and some experience in handling genomic data. You will join a multidisciplinary, committed and supportive team with the opportunity to work in conjunction with software developers, bioinformaticians, curators and scientists as well as colleagues and collaborators both in the Cancer Ageing and Somatic Mutation Research Programme and externally.

Job Area: Wellcome Genome Campus Grade: 3 Salary per annum: 26,880 to 32,201 Full Time, Part Time, Flexible Working: Full Time/Flexible working considered Contract Type: Permanent Reference:84970


Junior Data Engineers - COSMIC

We are seeking to recruit two passionate Junior Data Engineers to help us to develop the solutions for the world’s key cancer genomics resource, in COSMIC (Catalogue of Somatic Mutations of Cancer). We welcome anyone who has a computer science or bioinformatics background to join us on this opportunity to work in cancer genomics. You will be helping us in the exciting projects, to implement tools and processes on cloud environments.

 

About Us:

COSMIC is the key information source in global human cancer research. We exist to speed up the field of precision oncology so that every cancer journey can be tailored, accurate, and precise. We do this by streamlining and simplifying genomics data analysis for better prevention, diagnosis, and treatment research.

To achieve our vision, we're growing rapidly in content, scope and value. This role is due to the evolution and expansion of our massive biological datasets and products to enable this growth. We make a real difference to scientific research and to cancer patients around the world. Data is currently gathered from a variety of sources, from manual curation to structured repositories, and standardised into the COSMIC database before release via our analytic website. This genetic and genomic data is increasing in quantity and scope, its value is enhanced by analytic highlights, and this position will improve the handling, annotation, meaningful presentation and user access of this information. More specifically to this role, we provide excellent opportunities to apply best practises in software development, writing clean code, and taking a test-driven development approach.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323903/

Key Responsibilities:

  • You will support the development of new automated pipelines and workflows for data curation and release of COSMIC products.
  • Participate in developing solutions for storage and production pipeline of vast genomic data on cloud environment.
  • Contribute to maintaining and supporting the automatic pipelines and workflows on cloud platforms.

About You:

You do not need to have any biological background but must show enthusiasm to learn different genomic datasets in cancer genomics.  You must be a good communicator and able to understand the goals and aims of the collaborative COSMIC team and its customers of researchers, scientists and clinicians, globally. You will have experience in developing software and analytical tools across large datasets, ensuring throughput and quality.

Job Area: Wellcome Genome Campus Grade: 3 Salary per annum: 34,460-40,939 Full Time, Part Time, Flexible Working: Full Time/Flexible working considered Contract Type: Permanent Reference:84971


Principal/Senior Bioinformatician - Teichmann Group

Looking for an opportunity to demonstrate your computational skills to support research in human health?

The Teichmann lab is seeking enthusiastic and skilled applicants for the post(s) of Senior and Principal Bioinformatician(s) on open-ended contracts to contribute to the group’s research in the general area of the Human Cell Atlas. To perform this research, we make use of state-of-the-art technological advances, including multi-modal single cell genomics (e.g., transcriptomics, chromatin accessibility, and protein expression) and spatial genomics (e.g. 10x visium, FISH, in situ sequencing) technologies. We have access to extensive collections of sample repositories through collaboration with local and international groups. We are significant contributors to the Human Cell Atlas (HCA) and the Human Developmental Cell Atlas, international projects to systematically map all cells in the body across the lifespan. For more information about the HCA project click here.

You will have significant opportunities in leading or contributing to publications to help deliver the research portfolio in the Teichmann group. In addition, the Principal Bioinformatician post will include organising grant packages to allow you to lead projects within the Teichmann group field of research. The Principal Bioinformatician role will also be responsible for managing other members of the dry lab team.

As a Programme, we are committed to personal and professional development, and would work with you to support your career aspirations.   

 Your primary responsibilities include:

Senior Bioinformatician: -  (Salary range £38,433-£46,039 per annum)

  1.     Analyse large scale multi-modal single cell genomics and spatial genomics data to characterise the cell states  present in the tissue and their communication
  2.     Support and participate in the development of new computational methods to study cellular communication and gene regulatory networks
  3.     Suggest validation strategies to confirm hypotheses and predictions from 1) and 2) above

 Principal Bioinformatician: - (Salary range £46,199-£55,341 per annum)

  1. Leading dry lab staff members in the group
  2. Contributing to group’s scientific and organisational strategy
  3. Analyse large scale multi-modal single cell genomics and spatial genomics data to characterise the cell states present in the tissue and their communication
  4. Support and participate in the development of new computational methods to study cell state, cellular communication and gene regulatory networks
  5. Suggest validation strategies to confirm hypotheses and predictions from 3) and 4) above

Job Area: Research Programmes Grade: 1/2 Salary per annum: Dependent upon skills/experience - see below for further details Full Time, Part Time, Flexible Working: Full Time Contract Type: Permanent Reference:84967


Senior Bioinformatician in Spatial Multi-omics

The opportunity:

The Bayraktar group is seeking a senior bioinformatician for single cell and spatial transcriptomic studies of the healthy and diseased human brain. The role will support multiple computational projects across the lab, with a major focus on exploring how the tumour microenvironment (TME) drives malignant cell states in glioblastoma (GBM). Our exciting “GBM-space” project is an international collaboration funded by Wellcome LEAP to integrate single cell transcriptomics, epigenomics and spatial RNA/DNA-sequencing in order to systematically deconstruct TME-GBM cell interactions and plasticity in situ.

The team:

The Bayraktar group studies the cellular wiring of human tissues using spatial genomics, focusing on brain development and disease. We have significant expertise in single cell and spatial genomics and have developed new methods for multi-modal data integration (e.g. Cell2location in collaboration with Stegle team). We collaborate closely with leading computational biology teams in single cell and spatial biology. The GBM-space project led by Dr. Bayraktar brings us together with other experts in cancer and neurodevelopment across The German Cancer Research Centre (Oli Stegle), Cambridge (David Rowitch, Richard Mair) and the Crick (James Briscoe).

Key responsibilities:

  • Integrated single cell and spatial transcriptomic analysis of GBM and other human neurological disorders
  • Experimental data management and dissemination
  • Coordination of data analysis efforts across the Bayraktar team
  • Training other lab members in single cell and spatial transcriptomics analysis

 

Relevant publications of the team:

 Cell2location maps fine-grained cell types in spatial transcriptomic data. Kleshchevnikov V,  Shmatko A….Stegle O*,  Bayraktar OA*.

Nature Biotechnology 2022 40, 661–671.

https://www.nature.com/articles/s41587-021-01139-4

 

Transcriptome-wide spatial RNA profiling maps the cellular architecture of the developing human neocortex. Roberts K, Aivazidis A, Kleshchevnikov V, Li T, Fropf R, Rhodes M, Beechem J, Hemberg M, Bayraktar OA.

bioRxiv 2021

https://doi.org/10.1101/2021.03.20.436265

Job Area: Research Programmes Grade: 2 Salary per annum: 38,433 to 46,039 Full Time, Part Time, Flexible Working: Full Time Contract Type: Fixed Term Contract Length: 24 months Reference:84953


Senior Bioinformaticians - Cancer Research

The Experimental Cancer Genetics group aims to identify cancer genes and to understand their function. We are also interested in how genes interact to promote cancer development, and how these interactions may be exploited for therapy. The lab is a mixture of wet-lab experimental and data scientists.

About the Role:

We are seeking to recruit two Senior Bioinformaticians who can facilitate the scientific work of the group by helping drive the computational data analysis support for the DERMATLAS Project,  which aims to profile the somatic mutational landscape of rare skin tumour types and to understand the germline drivers of these conditions and the Sanger Comparative Oncogenomics project which is sequencing large numbers of animal tumours and comparing them to tumours from humans. You will need to be able to use existing pipelines and tools, as well as develop new analytical and statistical platforms, to effectively mine the data that we will generate.

About you:

You must be a good communicator and able to understand the objectives of the project and the clinical need. You must be proficient at devising and implementing software solutions and statistical analyses and able to effectively communicate with the wet-lab scientists. You will also be required to work with other bioinformaticians and also PhD students and postdocs in the team. This role would suit somebody with significant previous bioinformatics experience and a deep understanding of next-generation sequencing data analysis. You will work collaboratively with other computational biologists in the Cancer Ageing and Somatic Mutation Programme, as well as collaborators both within the Wellcome Sanger Institute and externally.

Job Area: Research Programmes Grade: 2 Salary per annum: 38,433-46,039 Full Time, Part Time, Flexible Working: Full Time/Flexible working considered Contract Type: Fixed Term Contract Length: 3 years Reference:84957


Senior Computer Biologist (Genome Curation)

The Opportunity: 

We are seeking a talented Computer Biologist to manually curate high throughput genome assemblies to chromosome-scale reference quality, using existing software tools that visualise data. Our project is generating genome assemblies for thousands of species. We need you to assess, analyse and improve the resulting assemblies to generate the best possible curated assemblies for use by the scientific community to further knowledge and understanding.

About you:

You will have a sound knowledge of genomic data and sequence assembly methods and possess excellent problem-solving skills to enable you to improve upon automated genome assemblies through genome curation using bespoke software and tools for which full training will be given.

You will be an excellent communicator and have experience of working collaboratively in a professional, international environment. You will be organised with the ability to work flexibly to support a number of projects and changing priorities whilst keeping to tight schedules. You will be focused on driving efficiency, working at scale and feeding back lessons learned from the curation process to assembly generation, influencing software development and overall assembly strategy.

About the Programme:

The Tree of Life Programme investigates the diversity of complex organisms through sequencing and cellular technologies to explore the evolution of life, provide the raw materials for new biotechnology and deliver tools and understanding for biodiversity conservation

The Darwin Tree of Life Project is a major national initiative, led by the Wellcome Sanger Institute, to provide high-quality ‘reference’ genome sequences for all eukaryotic species in the British Isles (Britain and Ireland). The project includes a wide range of partners across the UK such as the National History Museum (NHM), Kew Gardens, The Royal Botanic Gardens Edinburgh, The Earlham Institute, Wytham Woods and the Marine Biological Association (MBA).

There are further collaborations and partnerships with other large genome initiatives the Vertebrate Genomes Project, European Reference Genomes Atlas and Earth BioGenome Project.

Job Area: Research Programmes Grade: 2 Salary per annum: 38,433-46,039 Full Time, Part Time, Flexible Working: Full Time/ Part Time/Flexible Working Contract Type: Permanent Reference:84934