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Senior/ Principal Software Developer - Bacterial Genomics

We are looking to recruit a Senior/Principal Software Developer (grade dependent on skills and experience) to join a major international research project, funded by the Bill and Melinda Gates Foundation, that aims to sequence the genomes of a large collection of Streptococcus agalactiae samples to inform global disease prevention strategies.

About you

We are seeking to appoint a talented, enthusiastic and motivated individual who enjoys developing software solutions for the curation and analytics of large-scale biological datasets. The role would suit somebody with a degree in a computer science discipline and several years of practical experience developing software in large or complex projects, who is a confident user of UNIX systems, and feels at home both in the back-end and the front-end world.

About the role

The role will involve developing a software system for the management, analysis and visualisation of large genomic datasets. It will also require maintenance of the existing software infrastructure as well as working closely with the other team members to understand scientific software requirements and providing input for strategic decisions relating to the team’s informatics operations. 

About the team

The post will be within the Genomics of Pneumonia and Meningitis team that belongs to the Parasites and Microbes Programme at the Wellcome Sanger Institute. The Institute has a world class record of pioneering the use of large-scale genomic data analysis to understand pathogen biology, epidemiology and evolution. You will join a team that is engaged in many exciting research topics such as pathogen person-to-person transmission, global spread, acquisition of antimicrobial resistance and changes in pathogen population in response to vaccine implementation. Our studies are supported by genomic, clinical and epidemiological data for thousands of samples providing opportunity for well-powered analyses. We are a multi-disciplinary team that combines the expertise of microbiologists, mathematicians, and bioinformaticians. We also work in strong collaboration with our Pathogen Informatics group. For more information about the team please see Genomics of Pneumonia and Meningitis.

For informal enquiries about the post please contact Stephen Bentley (sdb@sanger.ac.uk)

Grade: 1 Salary per annum: 41,259 to 49,922 (G2)/ 48,290 to 58,432 (G1) Full Time or Part Time: Full Time Contract Type: Fixed Term Contract Length: Fixed term for 2 years with potential to extend for 3 years Reference:83640


Software Developer/ Bioinformatician

The Opportunity

We seek an experienced software developer/bioinformatician to develop the infrastructure to provide a catalogue of genetic risk scores for diseases. Genetic risk scores, also known as polygenic risk scores (PGS), have potential in predicting disease risk, enabling improved targeting of disease intervention strategies, thus improving human health. The PGS Catalog will store and distribute information and resources supporting both research and clinical uses of PGS (e.g. variant information, sample/cohort information, score development details, benchmarking). The Catalog will be developed with strong links to the NHGRI-EBI GWAS Catalog and will be a one-stop-shop for PGS for a wide range of diseases (e.g. CVD, breast cancer, diabetes).

About you

The role requires a developer to create a production quality website. You will be a strong web developer and programmer, ideally with some background knowledge or interest in genetics. You will be flexible and be willing to learn new languages to find the right tool for the right problem.

Responsible for the development and maintenance of the PGS Catalog software using a variety of tools, frameworks and technologies, you will possess excellent communication and interpersonal skill in order to work effectively with non-technical biologists and scientific developers to maintain a strong focus on the biological requirements of the Catalog.

More about the HDR Programme

Health Data Research UK is the new national institute for data science for health, which is being established in 2018 with long term (10 year+) funding support from research councils, UKRI, charitable and governmental research funders. The mission of HDR UK is to drive improvements in the health tripartite of patients and populations through research at regional and national scale. To deliver this mission, the Wellcome Sanger Institute (WSI), EMBL-European Bioinformatics Institute (EBI), and the University of Cambridge and its associated hospitals came together as the HDR Cambridge partnership.

Health Data Research UK is funded by UK Research and Innovation, Department of Health (England) and the UK devolved administrations, and leading medical research charities.

Grade: 2 Salary per annum: 41,259 to 49,922 Full Time or Part Time: Full Time Contract Type: Fixed Term - Special Project Contract Length: 3 years Reference:83586


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