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Postdoctoral Fellow - Mutational Signatures Projects

Salary range: £31115 – £39004 pa dependent on experience plus excellent benefits.

Fixed-term 12 months.

Mutational Signatures


An exciting computational position has become available working with Dr Serena Nik-Zainal, which involves developing computational and statistical methods in a pioneering project within the Cancer, Ageing and Somatic Mutation Programme.

The post holder will have responsibilities to develop computational and statistical methods for a project exploring somatic mutations associated with aberrations in DNA repair pathways. We are generating human iPSC lines from patients with germline mutations in DNA repair/replication pathways and generating parallel CRISPr/CAS-9 edited lines of the same genes. The over-arching objective is to explore mutational signatures in the context of the biological mechanisms associated with DNA repair, by integrating cellular/molecular approaches with genome-wide assays including genomic sequencing, RNA-seq and ChIP-seqAn exciting computational position has become available working with Dr Serena Nik-Zainal, which involves developing computational and statistical methods in a pioneering project within the Cancer Genomics Programme.


Job Reference

Essential Skills

  • PhD in a relevant subject area (Statistics, Computational Biology, Population Genetics/Genomics, Computer Science, Physics)
  • Strong statistical and quantitative skills
  • Strong publishing record
  • Excellent programming skills (both interpreted and compiled languages e.g. C/Fortran +Perl/Python/Ruby)
  • Familiarity with statistical modeling and software
  • Extensive experience of UNIX/Linux and cluster computing
  • Experience with very large data sets
  • Extensive experience of communicating effectively internally at all levels and with select external individuals
  • Ability to communicate ideas and results effectively
  • Ability to work independently and organise own workload



Ideal Skills

  • Experience with analysis of -omics data sets
  • Previous experience with QTL analysis
  • Previous experience with stem cells
  • Some understanding of genomics assays (RNA-seq, ChIP, genome sequencing) would be advantageous

Other information

A detailed role profile and further information regarding the new program can be found on our website at:

The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.

The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and will soon host Genomics England Limited’s 100,000 Genomes Sequencing Centre. The Campus is also home to the Wellcome Genome Campus Courses, Conferences and Public Engagement (CCPE) programme. The CCPE programme delivers training and engagement focussed around genomics, its applications, and implications.  Its vision is to inspire a range of audiences both on the Campus and beyond it, and make the world of genomics open and accessible to all.

To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops. In addition the Campus is home to the Wellcome Trust Advanced Course and Scientific Conferences programme and the Wellcome Trust Conference Centre.

Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

Please include a covering letter and CV with your application.  

Applications will be considered and reviewed on an on-going basis.