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Postdoctoral Fellow - Computational Genomics

Salary range: £31,115 to £39,004 dependent on experience.

Fixed-term 3 years.

A postdoctoral position is available in Computational Genomics at the Wellcome Trust Sanger Institute under the leadership of Dr Daniel Gaffney.

The long-term goal of the lab is to understand how genetic changes influence gene regulation, using a combination of statistical and experimental approaches. The post-holder will develop computational methods to analyze and integrate a wide variety of high-throughput sequencing data, with the goal of understanding how variation in gene regulation and expression affects complex phenotypes and disease susceptibility. The successful applicant will also have the opportunity to directly test computational results experimentally using CRISPR/Cas9 genome editing, working with the experimental members of the group. The successful applicant will also be expected to develop his or her own research interests as the project progresses.

Candidates in Biology with a strong background in quantitative analysis and population genetics are strongly encouraged to apply. We also welcome candidates with a background in Physics, Statistics or Computer Science with strong interests in computational biology. Excellent programming skills, experience with very large data sets and an ability to work as part of a team are essential. The post-holder will work as part of the Gaffney group at WTSI, for more information on the group’s research see:

Job Reference

Essential Skills

  • PhD in a relevant subject area (Computational Biology, Population Genetics/Genomics, Computer Science, Physics)
  • Strong publishing record
  • Strong statistical and quantitative skills and familiarity with statistical modeling and software
  • Excellent programming skills (C, C++, Perl, Python, Java) and extensive experience of UNIX/Linux and cluster computing
  • Ability to communicate ideas and results effectively
  • Ability to work well with other team members
  • Ability to work to tight deadlines

Ideal Skills

  • Previous experience in population genetic analysis
  • Experience with analysis of -omics data sets
  • Some familiarity with the stem cell biology

Other information

The goal of our lab is to understand how regulatory variants alter cellular phenotypes using a variety of experimental and computational approaches. The Sanger Centre offers a world-class academic environment, access to cutting edge sequencing facilities and extensive expertise in genome analysis and human genetics.

Postdoctoral Fellows are typically in their first or second postdoctoral position as part of a period of early career research training. Successful applicant(s) who have submitted their PhD thesis and are awaiting their PhD award are encouraged to apply. This position is initially for a fixed term of 3 years. For further information please contact Daniel Gaffney on

Campus Life

The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.

The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and will soon host Genomics England Limited’s 100,000 Genomes Sequencing Centre. The Campus is also home to the Wellcome Genome Campus Courses, Conferences and Public Engagement (CCPE) programme. The CCPE programme delivers training and engagement focussed around genomics, its applications, and implications.  Its vision is to inspire a range of audiences both on the Campus and beyond it, and make the world of genomics open and accessible to all.

To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops. In addition the Campus is home to the Wellcome Trust Advanced Course and Scientific Conferences programme and the Wellcome Trust Conference Centre.

Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

Please include a covering letter and CV with your application.  

Closing date for applications:  12th December 2016, however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline.