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Postdoctoral Fellow - Mutational Signatures

Salary range: £31,115 to £39,004 per annum plus excellent benefits.

 Fixed-Term until: 30/09/2017

A postdoctoral position is available at the Wellcome Trust Sanger Institute (WTSI) under the leadership of Professor Sir Mike Stratton to work on mutational signatures as part of the Cancer, Ageing and Somatic Mutation Programme. This is an exciting opportunity for the successful candidate to apply cutting edge technologies, utilising biochemical and molecular assays and novel bioinformatic algorithms, to unravel the pathways driving APOBEC-associated mutagenesis in human cancer. The experimental work will be accompanied by the large-scale analyses of next-generation sequencing data to extract APOBEC-associated mutational signatures, which are used as a readout of the corresponding mutagenesis in human cancer cells. Hence, the project requires an ability to plan, perform and simultaneously coordinate both wet and dry laboratory-based experiments.

Job Reference

Essential Skills

  • PhD in Biological Sciences
  • Excellent cell culture, flow cytometry and molecular biology skills
  • Expertise in computational biology and processing of next-generation sequencing data (DNA and RNA) and designing bespoke solutions to answer specific biological questions
  • Ability to use bioinformatic approaches to identify mutational signatures from next-generation sequencing data and excellent biological understanding of the underlying concepts
  • Previous experience in single cell genomics (computational and laboratory experience)
  • Experience in cancer genetics and genomics
  • Excellent organisational and communication skills, together with the ability to work well within a team
  • Other knowledge, skills and experience as appropriate to the research area, e.g. next-generation DNA- and RNA-sequencing protocols and data-analyses (paired-end mapping, genetic variant calling, etc.)

Other information

The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.

The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and will soon host Genomics England Limited’s 100,000 Genomes Sequencing Centre. The Campus is also home to the Wellcome Genome Campus Courses, Conferences and Public Engagement (CCPE) programme. The CCPE programme delivers training and engagement focussed around genomics, its applications, and implications.  Its vision is to inspire a range of audiences both on the Campus and beyond it, and make the world of genomics open and accessible to all.

To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops. In addition the Campus is home to the Wellcome Trust Advanced Course and Scientific Conferences programme and the Wellcome Trust Conference Centre.

Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

Please include a covering letter and CV with your application.  

Closing date for applications:  14th December 2016however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline.