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Postdoctoral Fellow - Single cell RNA seq of cell models

Salary £31,115 to £39,004pa plus excellent benefits.

Two year fixed-term position 

A postdoctoral position is available at the Wellcome Trust Sanger Institute (WTSI) under the leadership of Dr Martin Hemberg (WTSI) and Dr Rick Livesey (Gurdon Institute). The position provides an exciting opportunity for the successful candidate to create multicellular stem cell-derived models of the human cerebral cortex. Using established directed differentiation protocols, cortical excitatory neurons, interneurons and microglia will be differentiated from induced pluripotent stem cells (iPSC) reprogrammed from patients harboring familial Alzheimer’s disease mutations and isogenic control lines. Single cell RNA sequencing of these models will be performed to provide insights into the neuronal and inflammatory pathways involved in Alzheimer’s Disease pathogenesis. The candidate will collaborate extensively during this process with the Teichmann and Liu groups (WTSI) in order to optimise the preparation of samples for single cell sequencing and interpret the data produced. 

The post-holder will be expected to spend most of their time at the Gurdon Institute. The successful candidate will develop methods to create a complex co-culture system that incorporates these three major cell types to generate a more physiological model of Alzheimer’s disease initiation in vitro than those that are currently employed. We welcome candidates with a background in cell biology, molecular biology or developmental biology with extensive experience in performing cell and molecular biological assays. Experience in embryology or mammalian cell culture are highly desirable, as is a background with handling human iPSCs or immune cells. The successful candidate will have the opportunity to interact with experimental research and computational teams working at the Wellcome Trust/Cancer Research UK Gurdon Institute, the WTSI and at Biogen Inc. and will become part of team employing cutting edge cellular and transcriptomic techniques.

Job Reference

Essential Skills

  • Postgraduate qualification in Biological Sciences, or equivalent qualification
  • An excellent record of research publications in high impact journals
  • Extensive experience of core molecular and cell biology techniques
  • Extensive experience with and mammalian cell culture
  • Excellent organisational, communication skills and work ethic
  • Ability to independently develop, optimise and deploy research support, as a member of a closely collaborative team

Ideal Skills

  • A background in neurobiology and Alzheimer’s disease
  • Experience in handling human induced pluripotent stem cells
  • Experience in protocols for human IPS cell differentiation assays

Other information

The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.

The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and will soon host Genomics England Limited’s 100,000 Genomes Sequencing Centre. The Campus is also home to the Wellcome Genome Campus Courses, Conferences and Public Engagement (CCPE) programme. The CCPE programme delivers training and engagement focussed around genomics, its applications, and implications.  Its vision is to inspire a range of audiences both on the Campus and beyond it, and make the world of genomics open and accessible to all.

To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops. In addition the Campus is home to the Wellcome Trust Advanced Course and Scientific Conferences programme and the Wellcome Trust Conference Centre.

Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

Please include a covering letter and CV with your application.  

Closing date for applications:  2nd January 2017however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline.