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Postdoctoral Fellow - neurobiology and bioinformatics

Salary £31,115 to £39,004 plus excellent benefits.

Fixed term for 2 years.Open Targets

The Wellcome Trust Sanger Institute conducts cutting edge genomic research and the focus of our group is to develop new methods and models that will further our understanding of gene expression and gene regulation. We are looking for a dynamic and motivated Postdoctoral Fellow to join the Hemberg Faculty Team and undertake research into neurobiology and bioinformatics. The successful candidate will be expected to contribute to the formulation and submission of research publications and research proposals as well as help manage and direct this complex and challenging project, as opportunities allow.

The primary goal of this position is to be involved in the Open Targets funded study of human neuronal cultures derived from patients with familial Alzheimer’s disease (AD) mutations using single-cell RNA-seq (scRNA-seq). The main goal is to characterize and compare different cell-types for mutants and controls to identify the pathways that result in early onset AD. This will require using established pipelines and software for analysing scRNA-seq data, as well as developing novel methods for identifying differentially expressed genes and inferring gene regulatory networks. The project is a collaboration with the Livesey and Teichmann labs, and an important aspect of this role will be to interact with members of those groups for the analysis and interpretation of the data.

Job Reference

Essential Skills

  • PhD (or equivalent) in Mathematics, Physics or Computer Science
  • Ability to independently solve complex scientific/technical problems and manage scientific projects 
  • Excellent communication skills
  • Self-motivation and diligence
  • Ability to work with an international group of scientists
  • Good publication track record

Ideal Skills

  • Advanced bioinformatics skills in NGS data analysis
  • Good understanding of genomics and molecular biology
  • Strong programming skills
  • Experience with single-cell genomics

Other information

The project will form part of an Open Targets ( collaboration.

Open Targets is a recently established pioneering public-private initiative between GlaxoSmithKline, Biogen, EMBL-EBI (European Bioinformatics Institute) and the Wellcome Trust Sanger Institute (WTSI), located on the Wellcome Trust Genome Campus in Hinxton, near Cambridge, UK. Open Targets aims to generate evidence on the biological validity of therapeutic targets and provide an initial assessment of the likely effectiveness of pharmacological intervention on these targets, using genome-scale experiments and analysis. Open Targets aims to provide an R&D framework that applies to all aspects of human disease, and to share its data openly with the scientific community. The goal of the platform is to harness the power of 'big data' and genome sequencing to improve the success rate for discovering new medicines and share its data openly in the interests of accelerating drug discovery.

Campus Life

The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.

The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and will soon host Genomics England Limited’s 100,000 Genomes Sequencing Centre. The Campus is also home to Wellcome Genome Campus Connecting Science. Connecting Science inspires new thinking, sparks conversation and supports learning by drawing on the ground-breaking research taking place on the Campus. Its mission is to enable everyone to explore genomic science and its impact on research, health and society.

To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops.

Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

Please include a covering letter and CV with your application.  

Closing date for applications: 31st March 2017 , however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline.