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Senior/Advanced Research Assistant - Immune Genomics

Salary range £24,589 to £30,995 pa plus excellent benefits. (Advanced Research Assistant)

Salary range £31,498 to £39,729 pa plus excellent benefits. (Senior Research Assistant)


Fixed Term for 2,5 years

We are looking for a highly-motivated, self-driven person, who can ideally start immediately, to provide laboratory support to the Immune Genomics group led by Gosia Trynka. The prospective candidate will join a project that forms part of an Open Targets ( collaboration between GlaxoSmithKline, Biogen, EMBL-EBI (European Bioinformatics Institute) and the Wellcome Trust Sanger Institute (WTSI), where the goal is to use genome-scale experiments and analyses to generate evidence on the biological validity of therapeutic targets.

Our group studies how genetic variants control the function of the immune system and may lead to development of autoimmune diseases. We characterise the function of immune system through a combination of immune, genomic and proteomic assays carried out on primary human cells. We are looking for a candidate to join our group and perform high-throughput genomic and immune profiling protocols, including cell-sorting, FACS, immune cell assays, cell isolation and cell culture, as well as DNA and RNA extraction, PCR, ChIP, ATAC, proteomics and others.

We are seeking for someone who has strong research interests, is a team player, and will be actively involved in planning and leading the execution of experiments. Our group is a part of a dynamic and collaborative environment at the Wellcome Genome Campus. The position offers an exciting opportunity to work at one of the world-leading genomic research centres and to participate in the development and application of experimental techniques at the forefront of current genomic research.

Job Reference

Essential Skills

  • Degree in Biological Sciences, or equivalent qualification.
  • Previous work experience in a molecular biology laboratory.
  • Experience with core molecular biology techniques, including sample preparation, RT & qPCR, and RNA/DNA extraction.
  • Excellent organisational and communication skills.
  • Ability to work well as a member of a closely collaborative team.

Ideal Skills

  • PhD in Biological/Medical Sciences
  • Experience in mammalian cell culture.
  • Experience in handling and protocols for human blood samples and isolated immune cells.
  • Experience in immune cells assays, FACS and cell sorting.
  • Experience with protocols relevant to genomics of gene expression and gene regulation including chromatin immunoprecipitation (ChIP), and ATAC-seq.
  • Experience with proteomics.
  • Experience in scaling up protocols and sample management for high-throughput assays.

Other information

The project will form part of an Open Targets ( collaboration.

Open Targets is a recently established pioneering public-private initiative between GlaxoSmithKline, Biogen, EMBL-EBI (European Bioinformatics Institute) and the Wellcome Trust Sanger Institute (WTSI), located on the Wellcome Trust Genome Campus in Hinxton, near Cambridge, UK. Open Targets aims to generate evidence on the biological validity of therapeutic targets and provide an initial assessment of the likely effectiveness of pharmacological intervention on these targets, using genome-scale experiments and analyses. Open Targets aims to provide an R&D framework that applies to all aspects of human disease, and to share its data openly with the scientific community. The goal of the platform is to harness the power of 'big data' and genome sequencing to improve the success rate for discovering new medicines and share its data openly in the interests of accelerating drug discovery.

Sanger Life

The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.

The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and will soon host Genomics England Limited’s 100,000 Genomes Sequencing Centre. The Campus is also home to Wellcome Genome Campus Connecting Science. Connecting Science inspires new thinking, sparks conversation and supports learning by drawing on the ground-breaking research taking place on the Campus. Its mission is to enable everyone to explore genomic science and its impact on research, health and society.

To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops.

Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

Please include a covering letter and CV with your application.  

Closing date for applications: 5th April 2017 , however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline.