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Postdoctoral Fellow - Organoid Models of Cancer

Salary £31,115 to £39,004 plus excellent benefits.

Fixed term for 3 years.

We are seeking a postdoctoral scientist to join the Garnett Faculty team to research cancer gene function and cooperativity using CRISPR/Cas9 genome-editing in 3D organoid cultures. 

The teams research focuses on how genetic alterations contribute to carcinogenesis and impact on patient responses to anti-cancer medicines.  This research is at the interface of cancer genomics, cell biology and cancer therapeutics and employs high-throughput biology approaches together with detailed mechanistic studies. You will be working within a collaborative environment as part of a multi-disciplinary team of wet lab and computational biologists.

Candidates will have access to state-of-the-art facilities including high content microscopy, large-scale functional screening infrastructure (chemical, RNAi, CRISPR, transposon), DNA sequencing, patient-derived organoid cultures, and genetically engineered mouse models.

Postdoctoral Fellows are typically in their first or second postdoctoral position as part of a period of early career research training. The position is initially for a 3 year fixed term. 

Job Reference

Essential Skills

  • PhD in molecular biology or cell biology, or related discipline.
  • Mammalian cell culture experience
  • Self-motivation and diligence
  • Good organizational skills and accuracy
  • Proven track record in industry or academia
  • Exceptional communication skills
  • Team orientated approach

Ideal Skills

  • Experience using 3D cell culture
  • Experience using CRISPR/Cas9 genome-editing
  • Knowledge of cancer genetics and therapeutics

Other information

The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.

The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and will soon host Genomics England Limited’s 100,000 Genomes Sequencing Centre. The Campus is also home to Wellcome Genome Campus Connecting Science. Connecting Science inspires new thinking, sparks conversation and supports learning by drawing on the ground-breaking research taking place on the Campus. Its mission is to enable everyone to explore genomic science and its impact on research, health and society.

To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops.

Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

Please include a covering letter and CV with your application.  

Closing date for applications: 2nd April 2017, however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline.