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Postdoctoral Fellow - Statistical Geneticist

Salary range: £31,115 to £39,004 dependent on experience.

Fixed-term 3 years.

We are seeking to appoint a highly motivated Postdoctoral Fellow to join the Sandhu team at the Wellcome Trust Sanger Institute.

The role will have overall responsibility to lead projects involving the large-scale genome wide association studies in diverse African populations, with association analyses of rare and common genetic variants with cardiovascular, metabolic and infectious disease traits. The candidate will be expected to interpret GWAS results in the context of transcriptomic, and other functional data.

These projects will entail examining the genetic diversity among populations, and understanding associated analytic complexities. The work will involve designing the primary analyses, developing and implementing necessary analytical methods and pipelines.

The sucessful candidate will be aware of, and participate in strategic planning at the team level, and will be involved in driving forward the adoption of new sequencing technologies, such as 10x genomics and PacBio. The role is responsible, among other tasks, for the preparation and analysis of large datasets, as well as managing collaborative relationships within the frame of large international consortia. Training and supporting international researchers in large-scale genome analysis will also be part of the role core accountabilities.

Job Reference
82740

Essential Skills

  • Applicants should ideally have a first degree in a highly numerate subject (e.g. natural sciences, maths, statistics or computer science) or have a degree in another subject coupled with extensive experience working with quantitative data;
  • PhD in relevant discipline,
  • Proven understanding and experience in the fields of statistical genetics, high-throughput genome data analysis, and genomic databases;
  • Firm grasp of statistical genetics and tools fundamentals;
  • Experience with multivariate statistics or statistical modelling;
  • Strong computational skills, particularly in data parsing, cleansing, data modelling, analysis, and database design and implementation;
  • Knowledge and experience working in a unix/linux environment;
  • Demonstrated programming skills in shell scripting (e.g. bash, tcsh), interpreted/scripting languages (e.g. Perl, Python, R);
  • Experience with cluster computing;
  • Good written and verbal communication skills;
  • Ability to review, synthesise, and present scientific data and methods;
  • Experience providing advice, training and support to other researchers in the areas of bioinformatics and data analysis;
  • Demonstrable good time management  and project management and problem solving skills;
  • The ability to work well within a team.

Ideal Skills

  • A PhD in computer science, computational biology, biostatistics, bioinformatics, or similar fields is highly desired although not strictly necessary;
  • An understanding and experience with basic population genetics;
  • Direct experience processing NGS data (e.g. from Illumina platforms) for the identification of SNPs and structural variants;
  • Experience in using and integrating information from the main public bioinformatics resources;
  • Familiarity with the capabilities and limitations of NGS platforms and informatics pipelines, so that data can be appropriately integrated into analyses.
  • A PhD in computer science, computational biology, biostatistics, bioinformatics, or similar fields is highly desired although not strictly necessary;
  • An understanding and experience with basic population genetics;
  • Direct experience processing NGS data (e.g. from Illumina platforms) for the identification of SNPs and structural variants;
  • Experience in using and integrating information from the main public bioinformatics resources;
  • Familiarity with the capabilities and limitations of NGS platforms and informatics pipelines, so that data can be appropriately integrated into analyses.

Other information

The successful applicant may be required to travel occasionally to Africa.

The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.

The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and will soon host Genomics England Limited’s 100,000 Genomes Sequencing Centre. The Campus is also home to Wellcome Genome Campus Connecting Science. Connecting Science inspires new thinking, sparks conversation and supports learning by drawing on the ground-breaking research taking place on the Campus. Its mission is to enable everyone to explore genomic science and its impact on research, health and society.

To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops.

Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

Please include a covering letter and CV with your application.  

Closing date for applications:  8th June 2017, however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline.