Principal Bioinformatician

Salary £38,989 to £49,602 plus excellent benefits.

We are seeking to appoint a highly skilled Principal Bioinformatician to join the Sandhu team at the Wellcome Trust Sanger Institute.

The sucessful candidate will have overall responsibility to implement and develop as needed analysis pipelines for whole genome/transcriptomic/targeted sequencing data, using next and third generation sequencing platforms, including linked read (10x genomics) and single molecule (SMRT PacBio) sequencing, specifically in genetically diverse popualtions.

The role will provide the applicant with the opportunity to work with large-scale high resolution genomes from indigenous diverse populations, at the frontline of methodological development in genetics. The post holder will participate in strategic planning at the team level, and will drive forward the adoption of new sequencing technologies. The role is responsible, among other tasks, for the preparation and analysis of large datasets, as well as a for managing collaborative relationships within the frame of large international consortia.

Job Reference

Essential Skills

  • Applicants should ideally have a first degree in a highly numerate subject (e.g. natural sciences, maths, statistics or computer science) or have a degree in another subject coupled with extensive experience working with quantitative data;
  • Proven understanding and experience in the fields of genomics, data processing, high-throughput data analysis, and genomic databases;
  • Understanding of genome structure is a must;
  • Direct experience processing NGS data (e.g. from Illumina platforms) for the identification of SNPs and structural variants;
  • Firm grasp of univariate statistical analysis fundamentals;
  • Critical and analytic thinking around problems;
  • Strong computational skills, particularly in data parsing, cleansing, data modelling, analysis, and database design and implementation;
  • Knowledge and experience working in a unix/linux environment;
  • Demonstrated programming skills in shell scripting (e.g. bash, tcsh), interpreted/scripting languages (e.g. Perl, Python, R);
  • Experience with cluster computing;
  • Ability to anticipate needs and problems while creating solutions;
  • Good written and verbal communication skills;
  • Ability to review, synthesise, and present scientific data and methods;
  • Experience providing advice, training and support to other researchers in the areas of bioinformatics and data analysis;
  • Demonstrable good time management  and project management skills;
  • The ability to work within a team.

Ideal Skills

  • A PhD in computer science, computational biology, biostatistics, bioinformatics, or similar fields is highly desired although not strictly necessary;
  • Experience processing NGS data from the emerging technologies developed by PacBio, 10x Genomics, BioNano, Dovetail, ect.
  • Experience in using and integrating information from the main public bioinformatics resources;
  • Experience with multivariate statistics or statistical modelling;
  • Familiarity with the capabilities and limitations of NGS platforms and informatics pipelines, so that data can be appropriately integrated into analyses.
  • Programming skills in compiled language(s) (e.g. Java, C, C++);

Other information

The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.

The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and will soon host Genomics England Limited’s 100,000 Genomes Sequencing Centre. The Campus is also home to Wellcome Genome Campus Connecting Science. Connecting Science inspires new thinking, sparks conversation and supports learning by drawing on the ground-breaking research taking place on the Campus. Its mission is to enable everyone to explore genomic science and its impact on research, health and society.

To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops.

Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

Please include a covering letter and CV with your application.  

Closing date for applications:  2nd July 2017, however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline.