Research Assistant - Experimental Cancer Genetics

Salary £18,422 to £23,027 plus excellent benefits.

Fixed term for 2 years.

Open Targets

With the completion of the human genome and analysis of variation across multiple individuals, attention is now turning to the functional analysis of genes in mammals and their validation as therapeutic targets. Open Targets aims to provide evidence on the biological validity of therapeutic targets and provide an initial assessment of the likely effectiveness of pharmacological intervention on these targets, using genome-scale experiments and analysis. This open innovation, public-private partnership between WTSI, EMBL-EBI, GSK and Biogen, aims to provide an R&D framework that applies to all aspects of human disease, and to share its data openly with the scientific community (http://www.opentargets.org).

A new project funded by Open Targets, joint between the Experimental Cancer Genetics group headed by Dr David Adams at WTSI and GSK immuno-oncology, is to perform in depth analysis of Natural Killer (NK) cell surface protein interactors. The first phase of this project is a protein microarray screen to identify ligands for orphan NK cell receptors and to identify additional interactions. Following on from the identification of these ligand/receptor pairs their expression in normal tissue and tumours will be investigated. Finally, the functional importance of these pairs will be interrogated using a variety of assays.

We are looking for an enthusiastic individual to contribute to the generation of this data using a variety of laboratory techniques such as cell culture including manipulation of genes, flow cytometry, gene and protein expression analysis. Detailed record keeping is required, as is contribution to data analysis, review and reporting.

We offer a competitive reward package, including excellent benefits.

Job Reference
82775

Essential Skills

  • BSc or equivalent experience in biological sciences
  • Demonstrable ability to oversee the day to day direction of projects
  • Highly organised
  • Quality orientated
  • Methodical and thorough approach
  • Computing skills
  • Experience of cell culture methods
  • Expertise in flow cytometry
  • Familiarity of methods to characterise cell lines such as PCR and western blot

Ideal Skills

  • Ability to work in a team and lead technical aspects of a team
  • Proven ability to deliver small scientific projects
  • Experience of large scale, high throughput phenotyping
  • Knowledge of gene expression manipulation techniques
  • Experience of working with primary human immune cells
  • Knowledge of cytotoxicity and degranulation assays

Other information

Open Targets is a recently established pioneering public-private initiative between GlaxoSmithKline, Biogen, EMBL-EBI (European Bioinformatics Institute) and the Wellcome Trust Sanger Institute (WTSI), located on the Wellcome Trust Genome Campus in Hinxton, near Cambridge, UK. Open Targets aims to generate evidence on the biological validity of therapeutic targets and provide an initial assessment of the likely effectiveness of pharmacological intervention on these targets, using genome-scale experiments and analysis. Open Targets aims to provide an R&D framework that applies to all aspects of human disease, and to share its data openly with the scientific community. The goal of the platform is to harness the power of 'big data' and genome sequencing to improve the success rate for discovering new medicines and share its data openly in the interests of accelerating drug discovery.

Campus Life

The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.

The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and will soon host Genomics England Limited’s 100,000 Genomes Sequencing Centre. The Campus is also home to Wellcome Genome Campus Connecting Science. Connecting Science inspires new thinking, sparks conversation and supports learning by drawing on the ground-breaking research taking place on the Campus. Its mission is to enable everyone to explore genomic science and its impact on research, health and society.

To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops.

Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

Please include a covering letter and CV with your application.  

Closing date for applications: 14th July 2017, however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline.