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Postdoctoral Fellow - Human Genome Analysis

Salary £31,115 to £39,004 plus excellent benefits.

Fixed term for 3 years.

We are looking for an enthusiastic and skilled Postdoctoral Fellow in Human Genome Analysis to join the Soranzo team at the Wellcome Trust Sanger Institute (http://www.sanger.ac.uk/research/faculty/nsoranzo/). The post will suit an ambitious and talented individual who is interested in applying his/her skills at the interface of human disease and regulatory genomics.

The Soranzo team at the Sanger Institute studies genomic predisposition to cardiometabolic risk. In the last ten years, we have led international efforts to discover genetic variants associated with both established and emerging risk factors in cardiovascular disease, diabetes and immunity. Distinguishing features of our research are the focus on large-scale science, the use of genome sequencing for genomic exploration, and a focus on high-dimensional (‘omic’) phenotypes, including metabolomics and gene expression phenotypes.

As part of a Sanger-led initiative in Precision Medicine, we are performing whole-genome sequencing on thousands of individuals from the INTERVAL Study, an extensively phenotyped UK-wide Bioresource (see http://www.intervalstudy.org.uk for further information). The successful candidate will be primarily responsible for computational analyses of whole-genome sequencing datasets, with the aim to characterise different classes of sequence variants, including: (i) single-nucleotide variants/small insertion/deletion polymorphisms; (ii) structural and copy number variation; (iii) telomere length; (iv) mitochondrial DNA variation. Depending on skills and interest, there will be opportunities to develop research projects focusing on different applications of the data, including but not limited to population genetics, genome graphs, genotype imputation, or genotype-phenotype association studies. The appointed researcher will be embedded in an interdisciplinary team of computational scientists, bioinformaticians, statisticians and wet lab scientists. The results will inform efforts to characterise the properties and function of rare and low-frequency sequence variation affecting human complex phenotype.

The project will also involve collaboration with the Metabolic Disease Group at the Sanger Institute (Dr Ines Barroso), and the Cardiovascular Epidemiology Unit (CEU), Department of Public Health and Primary Care, University of Cambridge (Professor John Danesh and Dr Adam Butterworth).

Job Reference
82818

Essential Skills

  • Postgraduate degree in a quantitative science, including but not limited to physics, statistics, mathematics or computational biology.
  • Firm grounding in statistical and computational methods for genome analysis.
  • Experience in working with whole-genome sequence data.
  • Grounding in methods for calling different classes of sequence variation.
  • Programming skills in Perl, Python, C, C++ or equivalent languages.
  • Excellent communication, organisational and problem-solving skills.
  • High level report writing.
  • Ability to work independently and as part of a team.
  • Ability to work to tight timelines.
  • Ability to communicate efficiently with a diverse array of scientific expertise.
  • Enthusiasm, commitment and attention to detail.
  • Experience in working with the statistical programming language R.

Ideal Skills

  • Documented previous statistics experience working with large-scale genetic datasets in relation to complex human phenotype.
  • Strong interest in human disease and or population genetics.
  • Documented scientific writing skills.

Other information

The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.

The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and will soon host Genomics England Limited’s 100,000 Genomes Sequencing Centre. The Campus is also home to Wellcome Genome Campus Connecting Science. Connecting Science inspires new thinking, sparks conversation and supports learning by drawing on the ground-breaking research taking place on the Campus. Its mission is to enable everyone to explore genomic science and its impact on research, health and society.

To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops.

Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

Please include a covering letter and CV with your application.

Closing date for applications: 24th August 2017; however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline