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Senior Bioinformatician-CRUK Grand Challenge: Mutographs of Cancer Project

Highly motivated Bioinformatician required to develop State of the Art analysis tools for CRUK funded Grand Challenge.

Salary Range: £31,498 to £39,729, plus excellent benefits.

Fixed-Term contract for 5 years.

An exciting bioinformatics opportunity has become available under the leadership of Professor Sir Mike Stratton as part of the CRUK Grand Challenge, Mutographs of Cancer project.

Specifically, this position will involve helping to develop and apply novel algorithms to unravel the mutational signatures that will explain the major global differences in cancer incidence. This important project aims to understand the biological mechanisms underlying cancer-causing mutational processes and to explore their application towards surveillance of mutagenic exposures in human populations.

The successful candidate will be embedded in a multidisciplinary team and will be tasked with further developing the analysis software and workflows. This role involves working alongside world leading scientific and IT staff to analyse and interpret the large genomic sequencing data sets that will be generated.

This position would suit a Bioinformatician/Software Developer who enjoys developing software tools for the analysis of large genomic data sets. The analysis software needs to be efficient, visually appealing and interpretable by the scientific/clinical community. We are looking for an individual who enjoys working in a multi-disciplinary team environment to help solve complex IT issues which will ultimately aid our understanding of mutational processes in humans.

Job Reference

Essential Skills


  • Good degree in Bioinformatics, Mathematics, Physics or Computer Science with a scientific background 
  • Experience of statistical analysis in a bioinformatics (e.g. R and/or Julia) 
  • Software development skills (using Perl and/or Python)
  • Experience of handling Next Generation sequencing data 
  • LSF or Open Grid scheduling software 
  • Experience working, developing and compiling software tools in a UNIX/LINUX environment 
  • Ability to manage own projects
  • Ability to work independently, organise own workload and meet tight deadlines
  • Ability to communicate ideas and results effectively
  • Excellent communication skills, ability to interact across a multi-disciplinary team to develop and maintain good working relationships
  • Enjoy working as part of a team 

Ideal Skills

  • Software development using a compiled language (C,C++,Java)
  • Experience of VMware, OpenStack or Amazon Web Services (AWS)
  • ORACLE/MySQL databases 
  • Experience of workflow management IT systems 
  • Experience of working in an Agile Software Development Group 
  • Web development using Perl, Java, HTML(5), CSS, JavaScript 
  • Background in cancer genetics 

Other information

Cancer Research UK's Grand Challenge is the most ambitious cancer research grant in the world - a series of £20m awards supporting international, multi-disciplinary teams willing to take on the toughest challenges in cancer - providing the freedom to try novel approaches, at scale, in the pursuit of life changing discoveries.

The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.

The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and will soon host Genomics England Limited’s 100,000 Genomes Sequencing Centre. The Campus is also home to Wellcome Genome Campus Connecting Science. Connecting Science inspires new thinking, sparks conversation and supports learning by drawing on the ground-breaking research taking place on the Campus. Its mission is to enable everyone to explore genomic science and its impact on research, health and society.

To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops.

Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

Although experience of bioinformatics would be a distinct advantage, applications are welcome from enthusiastic and committed graduates or candidates from other fields who wish to pursue a career in bioinformatics whilst carrying out a challenging and rewarding role.

Please include a covering letter and CV with your application.  

Closing date for applications: 15th September 2017, however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline.