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Bioinformatician/ Data Scientist

Salary in the region of £37,000 plus excellent benefits

Fixed term for 2 years

We are looking for a talented and highly motivated data scientist/ bioinformatician to play a crucial role in new research on cancer mutations in the COSMIC team at the Sanger institute, Hinxton. In this study, we are aiming to characterise every genetic mutation in every form of cancer, to define - at high-resolution across global populations - the important events which are driving disease.

You will work together with COSMIC scientific team, bringing bioinformatic or data science expertise to a new project aiming to describe every cancer mutation across multiple biological properties. We aim to take a very broad approach across millions of variants and hundreds of cancer disease types, to identify which variants act as drivers of disease, then correlate how they work together to cause disease progression.

Working in the COSMIC team, the world’s largest and most detailed database of cancer mutations will be available to you. Within the broader Sanger Institute, you will have access to global specialists in genomics with decades of experience discovering new disease genes, and who are already exploring these data. In addition, this information is vital for use in pharmaceutical and clinical applications, so we have partnered with AstraZeneca on this project, working closely with their Oncology division, and therefore your research will impact directly on the discovery and development of new precision medicines.

We anticipate this project will become a major new resource to discover new targets in cancer genetics, and our research will ultimately have an impact on the clinical treatment of cancer patients when they reach hospital. You will also have opportunities to learn more about precision medicine, and how pharmaceutical development works. 

COSMIC - the Catalogue Of Somatic Mutations In Cancer - is an expert-curated database describing the wide variety of genetic variations associated with all forms of human cancer. A key resource underpinning cancer genetic research, COSMIC provides large high-quality datasets, methods and graphics to scrutinise the genetics causing this disease, giving insights to pharmaceutical design and patient therapies. Built within the world-leading Sanger Institute (UK) to support global research, millions of mutations across thousands of diseases can be explored at http://cancer.sanger.ac.uk.

The Wellcome Trust Sanger Institute operates at the forefront of genomics, sequencing and analyses targeting a wide range of genomes from single cell pathogens to higher vertebrates, with an emphasis on genomes relevant to human medicine and welfare.  The Cancer Genome Project at the Institute has led the way in the systematic analysis of cancer genomes by using the human genome sequence and high throughput mutation detection techniques to identify somatically acquired sequence variants/mutations and hence identify genes critical in the development of human cancers (http://www.sanger.ac.uk).

Job Reference
82917

Essential Skills

  • MSc in Bioinformatic or Computer Science discipline 
  • Highly self-motivated, able to work independently and organise own workload
  • Excellent communication and effective team-working skills  
  • Data handling skills
  • Experience of developing software

Ideal Skills

  • Good communication and presentation skills
  • Experience of developing software for scientific research
  • Knowledge of human or cancer genetics

Other information

The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.

The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and will soon host Genomics England Limited’s 100,000 Genomes Sequencing Centre. The Campus is also home to Wellcome Genome Campus Connecting Science. Connecting Science inspires new thinking, sparks conversation and supports learning by drawing on the ground-breaking research taking place on the Campus. Its mission is to enable everyone to explore genomic science and its impact on research, health and society.

To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops.

Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

Please include a covering letter and CV with your application.  

Closing date for applications: 7th December 2017, however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline.