Advanced Research Assistant
Salary in the region of £26,364 - £31,900 (dependant on experience) plus excellent benefits
Fixed term for 2 years.
We are seeking an enthusiastic individual to join our established team Sanger Malaria Programme as an Advanced Research Assistant.
The Sanger Institute Malaria Programme generates and analyses large-scale genome datasets in order to understand how parasite genetics affects the biology and epidemiology of malaria.
You will play a part in developing new genetic tools to manipulate Plasmodium genomes. Recent developments in our team have allowed us to scale up reverse genetic analysis of the rodent model malaria parasite Plasmodium berghei (Gomes et al. (2015) Cell Host Microbe PMID: 25732065). We are now turning our efforts towards human malaria parasites, with the focus of this role being the translation of vector production and transfection technology to human-infective species such as Plasmodium falciparum.
You will use a combination of advanced molecular biology techniques including Gibson assembly, recombineering and Gateway technology to produce gene targeting constructs. The role will also support the team with other molecular biology tasks associated with conducting genome-wide KO screens. This is chiefly a vector pipeline / production position, where the majority of the day-to-day activities will be to perform molecular biology techniques. However, the long-term goals of the role extends to transfecting the constructs into parasites at a mid to high throughput scale.
We consider applications equally from those who wish to work full time (37 hours) or for a minimum of 18.5 hours per week via a flexible working arrangement
- A biological sciences degree (BSc or equivalent), with previous significant experience working with DNA and being comfortable using a range of molecular biology techniques
- Experience of mammalian cell culture work, being used to working under sterile conditions.
- Previous experience working closely with other team members
- Excellent communication and collaboration skills
- Able to work without constant supervision, enjoys working independently but as part of a team, with an adaptable approach to your workload.
- Excellent organisation and record keeping skills with a methodical and technically approach
- Basic computer skills
• Experience in culturing Plasmodium falciparum is desirable but not essential
The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute.
Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and extraordinary scientific community, committed to delivering life-changing science with the reach, scale and imagination to solve some of humanity’s greatest challenges.
The Campus is a community of organisations working in genomic research, enterprise, education and discourse. It is home to some of the world's foremost institutes and organisations in genomics and computational biology, including the Wellcome Sanger Institute which is the largest organisation on Campus, the European Bioinformatics Institute (EMBL-EBI), Open Targets and Genomics England. Also located here is Connecting Science - its mission is to enable everyone to explore genomic science and its impact on research, health and society by drawing on the ground-breaking research taking place on the Campus.
Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.
Genome Research Limited is an Equal Opportunity employer. As part of our commitment to gender equality and promoting women’s careers in science, we hold an Athena SWAN Bronze Award. We will consider all applicants without discrimination on grounds of disability, sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.
Please include a covering letter and CV with your application. Closing date for applications: 28th March 2018