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Operational Lead (Global Health Research Unit)

Salary range: circa: £40000 pa plus excellent benefits

Fixed-term until 31st March 2021

The NIHR Global Health Research Unit (GHRU) on Genomic Surveillance of Antimicrobial Resistance (AMR) aims to provide intelligent global surveillance of bacterial pathogens using whole genome sequencing (WGS) through appropriate sampling and analysis in sentinel surveillance sites within strategically relevant countries. 

We are seeking an Operational Lead to lead front-line laboratory support for large scale sample management and sequencing of bacterial strains at The Centre for Genomic Pathogen Surveillance (CGPS) at The Wellcome Sanger Institute (WSI). You will facilitate transfer of expertise and ownership in four sentinel laboratories in strategic locations; India, the Philippines, Colombia and Nigeria.  Each laboratory has been chosen to represent a network of hospitals either actively or on the cusp of being involved in the surveillance of AMR within each country.  Expertise in interpretation through easy-to-use data tools and analytics will enable each location to further develop local research agendas and to feed data into broader global monitoring of particular pathogens between sites through open access databases.

You will take a lead in the development of cross-facility training programmes, SOPs and protocols (for sequencing and standard molecular and phenotypic testing), and build a network of laboratory expertise across units to operationalise the process of rollout of WGS for surveillance of AMR. 

You will have experience of managing/running a sequencing laboratory focussed on prokaryotic pathogens, along with an enthusiasm and appetite for operationalising standard procedures, QA and cross-site QC and the rollout of sequencing for embedding within in LMICs. 

You will exhibit an exquisite attention to detail, good laboratory practice and excellent interpersonal skills, liaising with the sequencing facilities and infrastructure at WSI to access, understand barriers and implement best practice in conjunction with local laboratory and facilities managers.

Job Reference

Essential Skills

  • BSc in biological sciences or equivalent experience
  • Previous experience of handling complex biological pipelines and smooth process management in one or more laboratories
  • Experience in DNA extraction, QC, sequence library creation and sequencing
  • Expertise in microbiological methods
  • Substantial organisational skills
  • Scientific and laboratory management experience
  • Health and safety experience
  • Training/supervision experience
  • Scientific understanding of troubleshooting and process improvement
  • Demonstrable success in working to deadlines and with numerous priorities
  • Effective communicator with the ability to develop and maintain relationships over protracted time periods
  • Willingness to travel to sentinel sites to support sequencing set up, training and build collaborations

Other information

The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute. 

Our Campus: Set over 125 acresthe stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and extraordinary scientific community, committed to delivering life-changing science with the reach, scale and imagination to solve some of humanity’s greatest challenges.  

The Campus is a community of organisations working in genomic research, enterprise, education and discourse. It is home to some of the world's foremost institutes and organisations in genomics and computational biology, including the Wellcome Sanger Institute which is the largest organisation on Campus, the European Bioinformatics Institute (EMBL-EBI), Open Targets and Genomics England.  Also located here is Connecting Science - its mission is to enable everyone to explore genomic science and its impact on research, health and society by drawing on the ground-breaking research taking place on the Campus.

Genome Research Limited is an Equal Opportunity employer. As part of our commitment to gender equality and promoting women’s careers in science, we hold an Athena SWAN Bronze Award. We will consider all applicants without discrimination on grounds of disability, sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

Please include a covering letter and CV with your application.

Closing date for applications 12 April 2018.