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Staff Scientist (Molecular Biology for single-cell sequencing)

Salary in the region of £36,373 - £44,011 (dependent on experience) plus excellent benefits

Permanent/Open contract

We are seeking a Staff Scientist to be responsible for developing, implementing and running complex molecular biology methods for single-cell (multi-omics) sequencing. You will develop novel protocols for single-cell analyses and will take the experimental lead in key scientific research projects by performing complex single-cell experiments.

This will require a high degree of technical innovation, in-depth knowledge of and creativity with molecular assays, attention to detail, and high-level troubleshooting skills. You will demonstrate high accuracy in experimental work, close coordination and effective communication with other team members and teams/pipelines; this will be critical to meet the goals of key biological projects.

You will also process primary human tissue to generate cell suspensions and will be responsible for coordinating health and safety procedures in the lab.

Job Reference

Essential Skills

  • PhD in Molecular Biology/Biotechnology/Genetics/Genomics 
  • Extensive experience with and in-depth knowledge of classical molecular biology techniques, including DNA/RNA/protein work (isolation, purification, amplification, quantification, characterization, modification), enzymes and enzymatic reactions 
  • Extensive experience with high-throughput next-generation sequencing methods, including barcoding strategies, limitations of platforms and knowledge of a wide range of library construction methodologies 
  • Experience with development of novel/adapted molecular biology protocols, preferably for nucleic acids analyses 
  • Ability to be inventive and to present novel ideas in the area of molecular method development 
  • Proven ability to self-study, in order to understand and implement novel / complex molecular biology techniques appearing in the field 
  • Experience with designing (complex) experimental workflows using existing methods 
  • Ability to carry out complex experiments over several days 
  • Ability to keep detailed records, including those of complex experiments and large sample sets 
  • Ability to write up detailed protocols/SOPs which capture all key details of a method 
  • Highly developed problem-solving skills 
  • Attention to detail and highly accurate working style 
  • Experience with cell culture 
  • Ability to organise own workload 
  • Ability to work independently and within a group 
  • Evidence for productivity in a research setting such as publications, patents, etc. 
  • Good written and oral communication skills 
  • Prior experience of using common PC packages Excel/Word 

Ideal Skills

  • Experience with liquid handling robots 
  • Experience with high throughput assays (e.g. microfluidics) 
  • Experience with single-cell molecular biology work 

Other information

The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute.

Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.

Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:

  • Group Defined Contribution Pension Scheme and Life Assurance
  • Group Income Protection
  • Private Health Insurance
  • 25 days annual leave, increasing by one day a year to a maximum of 30
  • Family friendly environment including options for flexible and part-time working, a childcare voucher scheme, Campus Nursery and Summer holiday club
  • Two days paid Employee Volunteering Leave a year
  • Employee Discount Scheme
  • Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities
  • Active Campus Sports and Social Club
  • Free Campus Bus Service

Genome Research Limited is an Equal Opportunity employer. As part of our commitment to equality, diversity and inclusion and promoting equality in careers in science, we hold an Athena SWAN Bronze Award and have an active Equality, Diversity and Inclusion programme of activity. We will consider all applicants without discrimination on grounds of disability, sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. We are open to a range of UK-based flexible working options including part-time or full-time employment as well as flexible hours due to caring or other commitments.

Please include a covering letter and CV with your application.  Closing date: 17th June 2018 - we are looking at interviews to take place in week commencing 16th July 2018.