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Senior Bioinformatician - Cancer Dependency Map Analytics

Salary £36,373 to £44,011 (dependant on experience) plus excellent benefits

Fixed term for 3 years

The Wellcome Sanger Institute is seeking for an experienced Bioinformatician to provide computational support to the international Cancer Dependency Map consortium, and to other projects engaged in the analysis of data from genome-editing and functional-genomics screens, in collaboration with Open Targets.

The selected candidate will join the Cancer Dependency Map Analytics team, actively interacting with the Cancer Dependency Map consortium, whose broad goal is to identify vulnerabilities and dependencies that could be exploited therapeutically in every cancer cell.

The successful candidate will be able to extensively use computational pipelines for pre-processing and quality control assessment of data from genome-editing screens, and to implement new analytical pipelines on an individual project needs’ basis extending existing software, writing, documenting and maintaining code packages on public/internal repositories. Past experience with genomic data curation and familiarity with the management of data from large-scale in-vitro drug/functional-genomic screens will be positively considered.

Finally, the selected candidate will interact with Open Targets partners and collaborators, and with web development teams to coordinate data/results flows on the public domain.

This position offers the opportunity to work at one of the world’s leading genomic centres at the forefront of genomic research. The successful candidate will have access to Sanger's computational resources, including a 15000+ core computational cluster, the largest in life science research in Europe, and multiple petabytes of high-speed cluster file systems.

We are part of a dynamic and collaborative environment at the Genome Campus and, although we seek someone who can work independently, the selected candidate will have the opportunity to interact with researchers across many programmes at the Institute.

Job Reference
83074

Essential Skills

  • PhD in a relevant subject area (Physics, Computer Science, Engineering, Statistics, Mathematics, Computational Biology, Bioinformatics) 
  • Full working proficiency in a scripting language (e.g. R, Python, Perl) 
  • Full working proficiency with software versioning systems (eg. Git, gitub, svn) 
  • Previous experience in creating, documenting, and maintaining finished software
  • Previous experience with implementing–omics data analysis pipelines on a cluster 
  • Basic knowledge of statistics and combinatorics 
  • Full working proficiency in UNIX/Linux 
  • Ability to communicate ideas and results effectively 
  • Ability to work independently and organise own workload 
  • Interest in bioinformatics and molecular biology 
  • Ability to work with others in a collegiate manner 
  • Ability to communicate effectively internally at all levels and with select external individuals 
  • Able to present internally 

Ideal Skills

  • Ability to devise novel quantitative models, use relevant mathematics-heavy literature 
  • Experience in formulating the world in statistical models and applying them to real data 
  • Strong publishing record 
  • Knowledge of genomics and molecular biology 
  • Previous experience with data from high throughput assays 
  • Previous experience with data from genetic screens 
  • Full working proficiency in a compiled language (e.g. C, C++, D, Fortran) 

Other information

The Cancer Dependency Map is a collaborative initiative involving the Wellcome Sanger Institute and the Broad Institute of Harvard and MIT. By leveraging the expertise and infrastructure available at both organisations, we aim to identify genetic dependencies and vulnerabilities that could be exploited therapeutically in every cancer cell, to advance personalized cancer treatments.

Open Targets is a pioneering public-private partnership between Biogen, Celgene, EMBL-EBI, GlaxoSmithKline (GSK), Takeda, and the Wellcome Sanger Institute and is located on the Wellcome Genome Campus in Hinxton, near Cambridge, UK. Open Targets brings together expertise from six complementary institutions to systematically identify and prioritise targets from which safe and effective medicines can be developed, to help others find good targets, and to get those targets adopted into drug discovery pipelines. We currently focus on oncology, immunology and neurodegeneration through an R&D framework that can be applied to all aspects of human disease. We believe that evidence generated in the most human relevant systems showing which targets are causing disease will have a significant impact on the successful development of new medicines. To build a good therapeutic hypothesis we need to find not only which targets are involved, but also how we might alter complex disease mechanisms.

Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.

Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:

  • Group Defined Contribution Pension Scheme and Life Assurance
  • Group Income Protection
  • Private Health Insurance
  • 25 days annual leave, increasing by one day a year to a maximum of 30
  • Family friendly environment including options for flexible and part-time working, a childcare voucher scheme, Campus Nursery and Summer holiday club
  • Two days paid Employee Volunteering Leave a year
  • Employee Discount Scheme
  • Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities
  • Active Campus Sports and Social Club
  • Free Campus Bus Service

Genome Research Limited is an Equal Opportunity employer. As part of our commitment to equality, diversity and inclusion and promoting equality in careers in science, we hold an Athena SWAN Bronze Award and have an active Equality, Diversity and Inclusion programme of activity. We will consider all applicants without discrimination on grounds of disability, sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. We are open to a range of flexible working options including part-time or full-time employment as well as flexible hours due to caring or other commitments.

Please include a covering letter and CV with your application. Closing date for applications: 17th June 2018. 

Contact francesco.iorio@sanger.ac.uk for informal enquiries