Postdoctoral fellow (CRISPR Screening)-Experimental Cancer Genetics
Salary range: £31,503 to £39,492 depending on experience plus excellent benefits
Fixed Term contract for 3 years
With the completion of the human genome and analysis of variation across multiple individuals, attention is now turning to the functional analysis of genes in mammals and their validation as therapeutic targets. Open Targets aims to provide evidence on the biological validity of therapeutic targets and provide an initial assessment of the likely effectiveness of pharmacological intervention on these targets, using genome-scale experiments and analysis. This pioneering public-private partnership between Biogen, Celgene, EMBL-EBI, GlaxoSmithKline, Takeda, and the Wellcome Sanger Institute, aims to provide a R&D framework that applies to all aspects of human disease, and to share its data openly with the scientific community (http://www.opentargets.org).
A new project funded by Open Targets, joint between the Experimental Cancer Genetics group headed by Dr David Adams at the Wellcome Sanger Institute together with Open Targets partners, is to perform in depth analysis of factors that control T cell survival and differentiation within the tumour microenvironment. This will involve the use of bespoke targeted CRISPR screens applied to primary cells and using in vivo tumour models in order to identify novel candidate genes and/or pathways for validation and in-depth characterization.
We are looking for a talented postdoctoral fellow to be responsible for the CRISPR library aspect of this project to include the generation and optimisation of the CRISPR reagents required for the in vivoscreens. You will follow the validation and characterisation phases of the project.
We offer a competitive reward package, including excellent benefits.
Postdoctoral Fellows are typically in their first or second postdoctoral position as part of a period of early career research training. You are encouraged to apply if you have submitted your PhD thesis and you are awaiting your PhD award.
- PhD in biological sciences (or similar)
- Extensive experience in a research environment with a well-established publication track record
- Demonstrable ability to lead the day to day direction of projects
- Highly organised
- Experience of CRISPR methods and screening
- Detailed knowledge of molecular biology techniques required for CRISPR library generation
Open Targets is a pioneering public-private partnership between Biogen, Celgene, EMBL-EBI, GlaxoSmithKline (GSK), Takeda, and the Wellcome Sanger Institute and is located on the Wellcome Genome Campus in Hinxton, near Cambridge, UK. Open Targets brings together expertise from six complementary institutions to systematically identify and prioritise targets from which safe and effective medicines can be developed, to help others find good targets, and to get those targets adopted into drug discovery pipelines.
We currently focus on oncology, immunology and neurodegeneration through an R&D framework that can be applied to all aspects of human disease. We believe that evidence generated in the most human relevant systems showing which targets are causing disease will have a significant impact on the successful development of new medicines. To build a good therapeutic hypothesis we need to find not only which targets are involved, but also how we might alter complex disease mechanisms.
Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.
Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:
- Group Defined Contribution Pension Scheme and Life Assurance
- Group Income Protection
- Private Health Insurance
- 25 days annual leave, increasing by one day a year to a maximum of 30
- Family friendly environment including options for flexible and part-time working, a childcare voucher scheme, Campus Nursery and Summer holiday club
- Two days paid Employee Volunteering Leave a year
- Employee Discount Scheme
- Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities
- Active Campus Sports and Social Club
- Free Campus Bus Service
Genome Research Limited is an Equal Opportunity employer. As part of our commitment to equality, diversity and inclusion and promoting equality in careers in science, we hold an Athena SWAN Bronze Award and have an active Equality, Diversity and Inclusion programme of activity. We will consider all applicants without discrimination on grounds of disability, sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. We are open to a range of flexible working options including part-time or full-time employment as well as flexible hours due to caring or other commitments.
Please include a covering letter and CV with your application. Closing date: 24th June 2018 however applications will be considered and reviewed on an ongoing basis and therefore the post may be filled before the deadline.