Postdoctoral Fellow - Rayner Group

Salary in the region of £31,503 - £39,492 (dependent on experience) plus excellent benefits

Fixed term for 3 years

The Rayner group uses large-scale experimental approaches to identify and prioritise malaria drug and vaccine targets. Focusing on the blood stages of human malaria parasite species, the group combines systematic genetic modification, proteomics, cellular phenotyping, biochemistry and sequencing to understand basic biology and to advance new therapeutic targets. One expanding area of focus is the prioritisation of vaccine targets for Plasmodium vivax. P. vivax causes the majority of malaria outside of Africa, but vaccine development for this organism has been hampered by the absence of an in vitro culture system in which to test candidates. The Rayner lab is collaborating with the lab of Prof. Manoj Duraisingh at the Harvard T.H. Chan School of Public Health, who has pioneered the development of ex vivo assays forP. vivax, to change the scale of P. vivax vaccine development.

There is now an opening for a three-year post-doctoral fellowship position working between the Rayner and Duraisingh labs to prioritise Plasmodium vivax blood-stage vaccine targets. The project will take a reverse vaccinology approach, systematically expressing large numbers of candidate antigens using a mammalian cell expression system, raising antibodies against them, and testing them for protective efficacy in ex vivo and in vitro assays. The project will require working closely with other scientists at the Sanger Institute and Harvard T. H. Chan School of Public Health, and with partners in malaria endemic countries. You will be independent and a self-starter, who will be keen to make the most of this exciting opportunity. You may be new to the malaria field, but you will have a strong track record in eukaryotic cell culture, protein expression and purification. While the position is a three year postdoctoral fellowship, the rich biology has many possibilities for the development of new independent projects, career development and support.

Job Reference

Essential Skills

  • PhD in molecular and cell biology 
  • Extensive experience in eukaryotic cell culture and recombinant protein purification
  • Able to communicate effectively about complex technical matters with both experts and non-experts 
  • Excellent organisation and record keeping skills
  • An independent working style with high self-motivation
  • A passion for problem solving and creative thinking

Ideal Skills

  • Experience working with Plasmodium parasites 
  • Experience performing lab-based experimental projects in malaria endemic settings 

Other information

The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute.

Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.

Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:

  • Group Defined Contribution Pension Scheme and Life Assurance
  • Group Income Protection
  • Private Health Insurance
  • 25 days annual leave, increasing by one day a year to a maximum of 30
  • Family friendly environment including options for flexible and part-time working, a childcare voucher scheme, Campus Nursery and Summer holiday club
  • Two days paid Employee Volunteering Leave a year
  • Employee Discount Scheme
  • Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities
  • Active Campus Sports and Social Club
  • Free Campus Bus Service

Genome Research Limited is an Equal Opportunity employer. As part of our commitment to equality, diversity and inclusion and promoting equality in careers in science, we hold an Athena SWAN Bronze Award and have an active Equality, Diversity and Inclusion programme of activity. We will consider all applicants without discrimination on grounds of disability, sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. We are open to a range of UK-based flexible working options including part-time or full-time employment as well as flexible hours due to caring or other commitments.

Please include a covering letter and CV with your application. Closing date: 6th August 2018