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Team Leader - Human Genetics Informatics

Salary in the region of £55,688 - £75,938 (dependent on experience) plus excellent benefits

Permanent/ Open Contract

The Wellcome Sanger Institute is seeking a talented and experienced team leader to lead a software development, deployment and management team that develops the informatics workflows and delivers the standard data products that are essential for research projects within the Human Genetics Programme. The successful candidate will drive the development and adoption of new bioinformatics approaches within the Programme, and influence informatics strategy more widely within the Institute.

The Wellcome Sanger Institute houses one of the largest set of computing assets dedicated to life sciences in the word, including ~45PB of data and 30,000 processing cores. The Human Genetics programme is the largest user of these compute facilities and is a world-leader in large scale genetic and genomic analyses. The Institute is transitioning from a traditional HPC architecture to a hybrid internal-external cloud-based strategy. The leader of the HGI team will be instrumental in driving and implementing this change within the programme.

We welcome candidates with expertise in full stack software development, large-scale genetic data analysis and cloud-based deployment and operations. The successful candidate will work closely with the eight Faculty groups within Human Genetics as well as IT and informatics experts throughout the institute, and on the wider campus. You will have a key role in improving our understanding, diagnosis and treatment of common and rare genetic diseases.

For further information on research in Human Genetics please visit: Human Genetics programme. For a discussion about the role, contact Nicola Corton ( and Matthew Hurles (

The Institute is an internationally outstanding genomic research centre with approximately 40 core Faculty teams and 1,100 employees based south of Cambridge. Our mission is to use genome sequences to advance understanding of the biology of humans and pathogens in order to improve human health. With core funding and state-of-the-art platforms in sequencing, high-performance computing, model organisms, genome editing and cellular genetics, we enable our researchers to concentrate on biological questions across a diverse range of genomic and genetic science, in both independent studies and large-scale collaborations. The result is a unique, vibrant and interactive research environment.

Job Reference

Essential Skills

  • Proven demonstrable experience in delivering robust software and data products for large-scale genetics/genomics research 
  • Detailed knowledge of core computer science concepts (e.g. object oriented design, memory management, algorithm implementation) and practices (e.g. version control, agile development, extreme programming) 
  • Experience of all phases of software development for large-scale analytical pipelines, including analytical programming, scripting and code review.  
  • Extensive experience programming in a number of languages 
  • Excellent communication skills 
  • A flexible and service oriented attitude 
  • Proven ability to deliver good quality solutions within fixed timelines 

Ideal Skills

  • Proven and demonstrable experience in managing a wide range of people-related issues through formal and informal mechanisms
  • Experience in managing software developers 
  • Intimate knowledge of UNIX based operating systems 
  • Experience with cloud-based technologies 
  • Experience analyzing large genetic datasets 
  • Experience with designing and implementing data security solutions 
  • Ability to understand and apply new concepts quickly 
  • Evidence of having successfully created software solutions dealing with large scale, complex problems 
  • Experience of dealing with rapidly changing priorities 
  • Highly developed problem solving skills 

Other information

The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute.

Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.

Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:

  • Group Defined Contribution Pension Scheme and Life Assurance
  • Group Income Protection
  • Private Health Insurance
  • 25 days annual leave, increasing by one day a year to a maximum of 30
  • Family friendly environment including options for flexible and part-time working, a childcare voucher scheme, Campus Nursery and Summer holiday club
  • Two days paid Employee Volunteering Leave a year
  • Employee Discount Scheme
  • Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities
  • Active Campus Sports and Social Club
  • Free Campus Bus Service

Genome Research Limited is an Equal Opportunity employer. As part of our commitment to equality, diversity and inclusion and promoting equality in careers in science, we hold an Athena SWAN Bronze Award and have an active Equality, Diversity and Inclusion programme of activity. We will consider all applicants without discrimination on grounds of disability, sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. We are open to a range of UK-based flexible working options including part-time or full-time employment as well as flexible hours due to caring or other commitments.

Applications should be accompanied by:

  • Curriculum vitae, complete list of publications and details of three referees
  • A covering letter outlining why you think you would be a good fit for the role, and your perspective on the key drivers of change in the informatics of large-scale human genetics research.

Closing date for applications: 5th September 2018. Interviews will be held in September/October.