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Postdoctoral Fellow - Cellular mapping of the human brain

Salary in the region of £31,503 - £39,492 (dependent on experience) plus excellent benefits

Fixed term for 3 years

We are looking to appoint a highly motivated postdoctoral fellow in developmental neuroscience to join Omer Bayraktar’s new group at the Wellcome Sanger Institute.

Our group will seek to explore the vast cellular diversity of cell types in the human body, with a primary focus in the brain. A remarkable meshwork of neuronal and glial cells lies at the root of our consciousness and exposes us to various neurodevelopmental and psychiatric diseases. To understand human behavior and neurological disorders, we need to understand how all the different neurons and glial cells talk to each other and build a functional brain. However, we lack large-scale approaches that can systemically map molecular interactions between human brain cell types and help identify developmental and disease-relevant developmental pathways.

You will lead an exciting project in mapping cell types and screening glial-neuronal interactions during human brain development. Your primary objectives will be 1) profiling neural cell types in the postnatal human cerebral cortex with single cell/nuclei RNA-sequencing and 2) large-scale identification of protein interactions between cortical glia and neurons. The transcriptomic profiling will be a part of the Human Cell Atlas (HCA) and you will work closely with a growing number of HCA teams at Sanger and elsewhere as well as various neuroscience labs across the UK. On large-scale protein interaction screening, you will collaborate closely with Gavin Wright’s group at Sanger.

Your work will help shape the future research questions in the lab and you will be supported to develop your own research projects within the scope of the group’s interests. You will also be exposed to related research in spatial tissue mapping and imaging in our group and will be encouraged to participate in the design and planning of these projects.

This is primarily a training post, with associated responsibility of the faculty team leader and Sanger Institute to ensure training is delivered.

Job Reference

Essential Skills

  • PhD in relevant wet-lab subject (e.g. Developmental Biology, Neuroscience, Molecular Biology)
  • Experience working with tissues and primary cells
  • Understanding of single-cell or nuclei RNAseq approaches
  • Understanding of ethics of working with human tissue samples
  • Experience of planning research projects
  • Excellent communication skills to allow efficient interactions with collaborators
  • Experimental troubleshooting skills
  • Experience of writing manuscripts for publication
  • Ability to work within a team

Ideal Skills

  • Experience performing single-cell or nuclei RNAseq on cells dissociated from primary tissue samples 
  • Experience with analysis of scRNAseq data 
  • Experience with high throughput screens sand assays 

Other information

The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute.

Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.

Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:

  • Group Defined Contribution Pension Scheme and Life Assurance
  • Group Income Protection
  • Private Health Insurance
  • 25 days annual leave, increasing by one day a year to a maximum of 30
  • Family friendly environment including options for flexible and part-time working, a childcare voucher scheme, Campus Nursery and Summer holiday club
  • Two days paid Employee Volunteering Leave a year
  • Employee Discount Scheme
  • Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities
  • Active Campus Sports and Social Club
  • Free Campus Bus Service

Genome Research Limited is an Equal Opportunity employer. As part of our commitment to equality, diversity and inclusion and promoting equality in careers in science, we hold an Athena SWAN Bronze Award and have an active Equality, Diversity and Inclusion programme of activity. We will consider all applicants without discrimination on grounds of disability, sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. We are open to a range of UK-based flexible working options including part-time or full-time employment as well as flexible hours due to caring or other commitments.

Please include a covering letter and CV with your application. Closing date: 2nd September 2018