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Postdoctoral fellow - Experimental Cancer Genetics

Salary in the region of £31,503 - £39,492 (dependent on experience) plus excellent benefits

Fixed term for 3 years

CRISPR saturation mutagenesis to define cancer driver mutations and germline predisposing alleles

We are looking for a talented postdoctoral fellow to join our team at the Wellcome Sanger Institute. In this project you will use new genome editing techniques such as multiplex homology directed repair and base editing to pre-emptively identify all possible cancer pre-disposing alleles by saturation mutagenesis of cancer driver genes.

Classical genetic approaches for interpreting variants, such as case-control or co-segregation studies, require finding multiple individuals with each variant to associate that variant with a disease state. Because the majority of variants are present in only a small fraction of the population or are private to an individual, this strategy has clear limits. Fully realising the clinical potential of genetics requires that we accurately infer pathogenicity even for rare or private variation. Many computational approaches to predicting variant effects have been developed, but they can identify only a small fraction of pathogenic variants with high confidence. Experimentally measuring a variant's functional consequences can provide clearer guidance, but individual assays performed only after the discovery of the variant are both time and resource intensive. You will initially start with genes that predispose to melanoma development but we will ultimately extend this approach across all cancer genes.

This project is a collaboration between the labs of Dr. David Adams (https://www.sanger.ac.uk/people/directory/adams-david) and Dr. Andrew Bassett (https://orcid.org/0000-0003-1632-9137) from Experimental Cancer Genetics and Cellular Engineering, respectively, and is suitable for an energetic postdoctoral fellow with an interest in CRISPR technology and some computational experience. Informal enquires can be made to David Adams (da1@sanger.ac.uk) or Andrew Bassett (ab42@sanger.ac.uk).

Job Reference
83187

Essential Skills

  • PhD in biological sciences (or similar) 
  • Extensive experience in a research environment with a well-established publication track record 
  • Demonstrable ability to oversee the day to day direction of projects 
  • Highly organised 
  • Experience of CRISPR methods and screening 
  • Detailed knowledge of molecular biology techniques required for CRISPR library generation 
  • Ability to work in a team and lead technical aspects of a team 

Other information

The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute.

Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.

Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:

  • Group Defined Contribution Pension Scheme and Life Assurance
  • Group Income Protection
  • Private Health Insurance
  • 25 days annual leave, increasing by one day a year to a maximum of 30
  • Family friendly environment including options for flexible and part-time working, a childcare voucher scheme, Campus Nursery and Summer holiday club
  • Two days paid Employee Volunteering Leave a year
  • Employee Discount Scheme
  • Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities
  • Active Campus Sports and Social Club
  • Free Campus Bus Service

Genome Research Limited is an Equal Opportunity employer. As part of our commitment to equality, diversity and inclusion and promoting equality in careers in science, we hold an Athena SWAN Bronze Award and have an active Equality, Diversity and Inclusion programme of activity. We will consider all applicants without discrimination on grounds of disability, sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. We are open to a range of UK-based flexible working options including part-time or full-time employment as well as flexible hours due to caring or other commitments.

Please include a covering letter and CV with your application. Closing date: 21st September 2018