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Postdoctoral Fellow - Transcriptomic Analysis of Immune Cells in Dengue Fever

Salary in the region of £31,503 - £39,492 (dependent on experience) plus excellent benefits

Fixed term for 2 years

We are seeking a Postdoctoral Research Fellow to carry out single cell transcriptome profiling of the innate immune response in dengue virus infected patients using single-cell RNA sequencing. Specifically the aim is to gain an insight into the immune mechanisms that allow the development of an asymptomatic infection followed by virus clearance versus those mechanisms that lead to fever or severe infection.

The role will be part of the Teichmann group working on a specific project with collaborators at Mahidol University, Thailand and Oxford University.

Job Reference

Essential Skills

  • PhD in immunology 
  • Extensive experience in T cell and B cell experiments and up to date knowledge of T and B cell biology 
  • Experience in transcriptomic analysis, including population RNA-seq and single cell RNA-seq with both plate-based and droplet based methods 
  • Expertise with data analysis and interpretation
  • Good publication track record in this area 
  • Ability to interact and work closely with the clinical teams in Thailand 

Ideal Skills

  • Excellent presentation skills
  • Excellent working knowledge of the literature

Other information

The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute.

Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.

Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:

  • Group Defined Contribution Pension Scheme and Life Assurance
  • Group Income Protection
  • Private Health Insurance
  • 25 days annual leave, increasing by one day a year to a maximum of 30
  • Family friendly environment including options for flexible and part-time working, a childcare voucher scheme, Campus Nursery and Summer holiday club
  • Two days paid Employee Volunteering Leave a year
  • Employee Discount Scheme
  • Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities
  • Active Campus Sports and Social Club
  • Free Campus Bus Service

Genome Research Limited is an Equal Opportunity employer. As part of our commitment to equality, diversity and inclusion and promoting equality in careers in science, we hold an Athena SWAN Bronze Award and have an active Equality, Diversity and Inclusion programme of activity. We will consider all applicants without discrimination on grounds of disability, sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. We are open to a range of UK-based flexible working options including part-time or full-time employment as well as flexible hours due to caring or other commitments.

Please include a covering letter and CV with your application. Closing date: 25th October 2018