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Postdoctoral Fellow - Cellular Genetics

Salary in the region of £31,503 - £39,492 (dependent on experience) plus excellent benefits

Fixed term for 3 years

The Trynka group at the Wellcome Sanger Institute is looking for a highly-motivated, self-driven postdoctoral fellow to join our group. We are at a very exciting times in genetics of complex diseases. There are thousands of genetic variants linked with risk of autoimmune diseases. Understanding how these variants affect cellular phenotypes would provide invaluable knowledge of the disease biology, allowing for better diagnosis and drug development. However, for most of the disease variants the function remains unknown.

The overarching theme of our research is to understand the role of genetic variants in regulating function of the immune system and in predisposition to the disease development. Our group combines large scale experimental and computational work. We use immune assays to challenge cells in different conditions and measure different cellular processes. The backbone to all our cellular readouts is a rich palette of genomic assays, which we use to profile gene expression regulation and chromatin activity in bulk, as well as at the single cell level. These approaches allow us to link how genetic variants regulate cellular responses.

We are seeking someone with strong research interests in genetics of autoimmune diseases, who is a team player, and will be actively involved in planning and leading the execution of large-scale experiments. You should have experience in immunogenomic assays and analysis of genomic data. We are looking for someone creative, who will engage in the ongoing research projects as well as demonstrate independent thinking and shape the future research questions in the lab. You will be supported to develop your own research projects within the scope of the group’s interests.

Our group is a part of a dynamic and collaborative environment at the Wellcome Genome Campus. The position offers an exciting opportunity to work at one of the world-leading genomic research centres and to participate in the development and application of experimental techniques at the forefront of genomic research.

Job Reference
83222

Essential Skills

  • PhD in immunology, genetics, molecular biology or relevant subject area
  • Experience in immunology assays (including cell sorting, FACS, isolating and culturing primary human cells)
  • High self motivation and critical thinking skills
  • Basic or proficient programming skills (e.g. Python, Perl, R).
  • Experience in analysis of large scale genomic datasets
  • Ability to communicate ideas and results effectively
  • Ability to work independently and organise own workload
  • Excellent written and spoken English
  • Experience writing scientific manuscripts
  • The ability to effectively communicate with collaborators ad occasionally present orally to large groups
  • Proven independent working style, problem solving, data analysis and generation of novel ideas

Ideal Skills

  • Experience of performing single-cell RNA-seq
  • Experience with analysis of scRNAseq data
  • Experience with CRISPR assays
  • Experience with genomic protocols including chromatin immunoprecipitation (ChIP) and ATAC-seq
  • Experience with high throughput screens and assays.

Other information

The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute.

Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.

Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:

  • Group Defined Contribution Pension Scheme and Life Assurance
  • Group Income Protection
  • Private Health Insurance
  • 25 days annual leave, increasing by one day a year to a maximum of 30
  • Family friendly environment including options for flexible and part-time working, a childcare voucher scheme, Campus Nursery and Summer holiday club
  • Two days paid Employee Volunteering Leave a year
  • Employee Discount Scheme
  • Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities
  • Active Campus Sports and Social Club
  • Free Campus Bus Service

Genome Research Limited is an Equal Opportunity employer. As part of our commitment to equality, diversity and inclusion and promoting equality in careers in science, we hold an Athena SWAN Bronze Award and have an active Equality, Diversity and Inclusion programme of activity. We will consider all applicants without discrimination on grounds of disability, sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. We are open to a range of UK-based flexible working options including part-time or full-time employment as well as flexible hours due to caring or other commitments.

Please include a covering letter and CV with your application.  Closing date: 26th October 2018