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Postdoctoral Fellow - Functional Genomics

Salary in the region of £31,503 - £39,492 (dependent on experience) plus excellent benefits

Fixed term for 3 years

We are looking to appoint a computational postdoctoral fellow in functional genomics to join Emma Davenport’s new group at the Wellcome Sanger Institute.

When a group of patients are treated with a drug, there can be substantial heterogeneity in their response to treatment. A better understanding of the sources of patient-to-patient heterogeneity both within a disease and in response to treatment is critical for the success of clinical trials and to improve drug usage in the clinic. Our group focuses on integrating functional genomics with clinical data in order to understand how genetics contributes to this patient-to-patient heterogeneity. We use our expertise in computational methods, wet lab molecular biology and data acquisition to apply sophisticated analytical strategies to cohorts of patients.

You will lead exciting new projects with clinical and industry collaborators to analyse RNA-seq datasets from cohorts of patients with inflammatory diseases such as sepsis and autoimmune diseases. The main aim is to identify gene expression signatures for predicting disease severity and treatment response as well as using quantitative trait locus (eQTL) mapping to understand the role of regulatory DNA in patient heterogeneity.  You will have the ability to think creatively and you will be supported to develop your own research projects within the scope of the group’s interests.  

Job Reference

Essential Skills

  • PhD in a relevant subject area (e.g. Biology, Genetics, Computational Biology, Statistics)
  • Ability to communicate effectively with interdisciplinary team members and collaborators
  • Ability to work both independently and as part of a team
  • Ability to work with others in a friendly and collegiate environment
  • Experience of writing manuscripts for publication
  • A passion for problem solving and creative thinking
  • Excellent organisational skills

Ideal Skills

  • Experience in the analysis of functional genomic datasets (e.g. gene expression datasets)
  • Proficiency in a scripting language (e.g. R, Python, Perl)
  • Ability to develop novel statistical/computational methods

Other information

The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute.

Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.

Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:

  • Group Defined Contribution Pension Scheme and Life Assurance
  • Group Income Protection
  • Private Health Insurance
  • 25 days annual leave, increasing by one day a year to a maximum of 30
  • Family friendly environment including options for flexible and part-time working, a childcare voucher scheme, Campus Nursery and Summer holiday club
  • Two days paid Employee Volunteering Leave a year
  • Employee Discount Scheme
  • Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities
  • Active Campus Sports and Social Club
  • Free Campus Bus Service

Genome Research Limited is an Equal Opportunity employer. As part of our commitment to equality, diversity and inclusion and promoting equality in careers in science, we hold an Athena SWAN Bronze Award and have an active Equality, Diversity and Inclusion programme of activity. We will consider all applicants without discrimination on grounds of disability, sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. We are open to a range of UK-based flexible working options including part-time or full-time employment as well as flexible hours due to caring or other commitments.

Please include a covering letter and CV with your application. Closing date: 29th October 2018