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Postdoctoral Fellow - Experimental Genomics

Salary in the region of £31,503 - £39,492 (dependent on experience) plus excellent benefits

Fixed term for 3 years

We are looking for a motivated postdoctoral fellow to join our team at the Wellcome Sanger Institute, to develop and apply large scale cellular and molecular methodologies to understanding the role of rare protein-coding and non-coding variation in causing developmental disorders. 

New technologies such as Saturation Genome Editing, Massively Parallel Reporter Assays, genome-wide CRISPR-knockout screens and CROP-seq allow us to address fundamental questions such as: To what degree do non-coding mutations contribute to rare genetic diseases?  What is the functional impact of individually changing every amino acid in a disease-associated protein?  What genetic factors impact on severity in rare genetic diseases?  We are interested in tackling these and other questions that naturally emerge from the large scale sequencing analysis projects of severe developmental disorders ongoing in the Hurles lab. 

Initial projects will focus on Saturation Genome Editing of developmental disorder associated genes, to improve our understanding of disease mechanism and improve clinical interpretation, but the PDF will be encouraged to develop their own ideas and projects aligned with the fundamental questions above.

Please contact Sebastian Gerety ( and Matthew Hurles ( for more information.

Job Reference

Essential Skills

  • PhD in biological sciences (or similar) 
  • Extensive experience in a research environment with a well-established publication track record 
  • Highly organised 
  • Detailed knowledge of molecular biology techniques, such as those required for CRISPR library generation 
  • Demonstrable ability to work independently 

Ideal Skills

  • Experience of CRISPR methods and screening 
  • Experience in cell culture techniques 
  • Bioinformatics experience

Other information

The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute.

Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.

Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:

  • Group Defined Contribution Pension Scheme and Life Assurance
  • Group Income Protection
  • Private Health Insurance
  • 25 days annual leave, increasing by one day a year to a maximum of 30
  • Family friendly environment including options for flexible and part-time working, a childcare voucher scheme, Campus Nursery and Summer holiday club
  • Two days paid Employee Volunteering Leave a year
  • Employee Discount Scheme
  • Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities
  • Active Campus Sports and Social Club
  • Free Campus Bus Service

Genome Research Limited is an Equal Opportunity employer. As part of our commitment to equality, diversity and inclusion and promoting equality in careers in science, we hold an Athena SWAN Bronze Award and have an active Equality, Diversity and Inclusion programme of activity. We will consider all applicants without discrimination on grounds of disability, sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. We are open to a range of UK-based flexible working options including part-time or full-time employment as well as flexible hours due to caring or other commitments.

Please include a covering letter and CV with your application.  

Closing date for applications: 5th November 2018, however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline.