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Postdoctoral Fellow in Population Genomics in Single Cells

Salary in the region of £31,503 - £39,492 (dependent on experience) plus excellent benefits

Fixed term for 3 years

A postdoctoral position is available in the Wellcome Sanger Institute under the leadership of Dr Daniel Gaffney. The candidate will use single cell sequencing in population scale data sets from a range in vitro and in vivo systems, in particular using cellular model systems based on human induced pluripotent stem cells. The goal of the project is to understand how common and rare genetic variation influences cellular behavior and function at a single cell level. One component of the work will build on our work as part of the Human Induced Pluripotent Stem Cells Initiative (www.hipsci.org). Another component will be to combine transcriptomic readouts in single cells with image-based cellular phenotypes.

Candidates in Biology with a background in quantitative analysis and population genetics are strongly encouraged to apply. We also welcome candidates with a background in Physics, Statistics or Computer Science with strong interests in computational biology. Excellent programming skills, experience with very large data sets and an ability to work as part of a team are essential. The post-holder will work as part of the Gaffney group at WTSI, for more information on the group’s research see: http://www.sanger.ac.uk/science/groups/gaffney-group

The goal of our lab is to understand how regulatory variants alter cellular phenotypes using a variety of experimental and computational approaches. The Sanger Centre offers a world-class academic environment, access to cutting edge sequencing facilities and extensive expertise in genome analysis and human genetics.

Postdoctoral Fellows are typically in their first or second postdoctoral position as part of a period of early career research training. Successful applicant(s) who have submitted their PhD thesis and are awaiting their PhD award are encouraged to apply. This position is initially for a fixed term of 3 years. For further information please contact Daniel Gaffney on dg13@sanger.ac.uk

Job Reference
83283

Essential Skills

  • PhD in a relevant subject area (Computational Biology, Population Genetics/Genomics, Computer Science, Physics)
  • Strong publishing record
  • Strong statistical and quantitative skills and familiarity with statistical modeling and software
  • Excellent programming skills and extensive experience of UNIX/Linux and cluster computing
  • Ability to communicate ideas and results effectively
  • Ability to work well with other team members
  • Ability to work to tight deadlines

Ideal Skills

  • Previous experience in population genetic analysis
  • Experience with analysis of -omics data sets
  • Some familiarity with the stem cell biology

Other information

The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute.

Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.

Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:

  • Group Defined Contribution Pension Scheme and Life Assurance
  • Group Income Protection
  • Private Health Insurance
  • 25 days annual leave, increasing by one day a year to a maximum of 30
  • Family friendly environment including options for flexible and part-time working, a childcare voucher scheme, Campus Nursery and Summer holiday club
  • Two days paid Employee Volunteering Leave a year
  • Employee Discount Scheme
  • Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities
  • Active Campus Sports and Social Club
  • Free Campus Bus Service

Genome Research Limited hold an Athena SWAN Bronze Award and will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

Please include a covering letter and CV with your application.  Closing date: 6th January 2019