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Senior Research Assistant - Cellular Generation and Phenotyping

Salary in the region of £33,599 to £40,652 (dependent on experience),plus benefits

A new opportunity has arisen for a talented cell biology specialist to support the Cellular Generation and Phenotyping (CGaP) team. You will be working as part of a team on a project involving differentiation of induced pluripotent stem cells (iPSC) and the use of multi-drug resistant bacteria.

  • Do you thrive in a multi-disciplinary team, working together to solve complex cell biology issues?
  • Have you ever worked in a R&D, high throughput or process driven setting?
  • Do you have experience in differentiating iPSC or working in containment levels 2 or 3 (CL2/CL3)?
  • Alternatively, do you have extensive experience in cell biology?

If you said yes to the above questions, then this could very well be the job for you.

We are a core facility, responsible for providing cell biology resource and expertise to the wider institute. We do this by running multiple, diverse, high throughput projects for various faculty teams from across the Sanger Institute. Our current portfolio of projects includes, iPSC derivation and differentiation toward myeloid and neuronal lineages, genome wide CRISPR screens, organoid derivation, the Human Cell Atlas Initiative and the generation of Plasmodium mutants as well as work with various species of the pathogen Klebsiella. We work closely as a team of Scientific Managers, Research Assistants and Faculty members to successfully deliver large scale projects.

As a Senior Research Assistant you will play a fundamental role in delivering a project involving differentiation of iPSC into macrophages and their exposure to different species of the pathogen Klebsiella. The team you will be working with will be running in parallel other projects consisting of deriving iPSC from blood samples and performing a CRISPR-Cas9 screen into iPSC. Over time there will be scope for you to move between diverse projects.

Your role will also include offering day to day support to the team including, training, troubleshooting and identifying areas for process improvement. A fundamental aspect of the role will be to inspire, develop and mentor junior staff, as well as working closely with the Senior Scientific Managers to successfully deliver projects.

In addition to the lab work you will be expected to have strong time management and organisational skills, be an excellent communicator as you could acquire line management responsibilities. 

Job Reference

Essential Skills

  • BSc in Biology plus extensive cell biology laboratory experience
  • Prior experience of running and developing cell based assays and processes, including cell culture systems, reporter assays, flow cytometry, ICC, PCR, etc.
  • Ability to troubleshoot complicated laboratory processes
  • Experience of identifying and successfully resolving complex scientific/technical issues
  • Proven track record in generating and analysing high quality data
  • High attention to detail and good record keeping
  • Proven ability to be able to organise and schedule your own work
  • Proven experience in training and developing others in scientific techniques
  • Excellent communication skills
  • Experience in collaborating with others and effectively working in teams

Ideal Skills

  • Experience in iPSC differentiation.
  • Experience working in CL2/CL3 settings.
  • Experience in CRISPR-Cas9 library screening.
  • Proven ability to be able to organise and schedule more junior staffs work.

Other information

Our Campus: Set over 125 acresthe stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and extraordinary scientific community, committed to delivering life-changing science with the reach, scale and imagination to solve some of humanity’s greatest challenges.  

The Campus is a community of organisations working in genomic research, enterprise, education and discourse. It is home to some of the world's foremost institutes and organisations in genomics and computational biology, including the Wellcome Sanger Institute which is the largest organisation on Campus, the European Bioinformatics Institute (EMBL-EBI), Open Targets and Genomics England.  Also located here is Connecting Science - its mission is to enable everyone to explore genomic science and its impact on research, health and society by drawing on the ground-breaking research taking place on the Campus.

Genome Research Limited is an Equal Opportunity employer. As part of our commitment to gender equality and promoting women’s careers in science, we hold an Athena SWAN Bronze Award. We will consider all applicants without discrimination on grounds of disability, sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

Please include a covering letter with your application describing how you meet the essential criteria for this role.

Closing date: 10th January, 2019

 Interviews are expected to take place week commencing 28th January.