Advanced Research Assistant - Haematological Cancers

Salary in the region of £26,960 - £32,622 (dependent on experience) plus excellent benefits

Fixed term until 31st January 2020

An Advanced Research Assistant post is available for a motivated individual interested in the pathogenesis of leukaemias and the identification of novel therapeutic targets for the treatment of these diseases. The laboratory uses a combination of in vitro, cellular and animal models to study the impact of cancer gene mutations in leukaemogenesis. Genome-wide CRISPR/Cas9 screens are used to identify genetic vulnerabilities in leukaemia cells engineered to harbour specific leukaemia-associated mutations, while complementary in vitro studies address the mechanistic role of specific genetic vulnerabilities in leukaemia survival.

The successful applicant will perform routine molecular biology tasks e.g. manipulation of recombinant DNA and cell culture. The research assistant will work alongside other members of the group to prepare and analyse tissues using flow cytometry. The individual may be involved in new protocol development, necessitating a methodical approach at the bench and detailed record keeping. While team work is expected, the individual must also demonstrate the ability to independently trouble shoot and adapt protocols where necessary.

Previous experience of flow cytometry and molecular cloning would be advantageous. Given competing demands, the individual needs to be able to work flexibly between projects.

Job Reference

Essential Skills

  • BSc or equivalent experience in biological sciences
  • Familiarity with general molecular biology, biochemistry or cell biology techniques
  • Ability to follow written protocols accurately
  • Ability to adapt and plan protocols to own needs
  • Methodical approach to benchwork
  • Meticulous documentation of work and data
  • Ability to work both independently and within a small team
  • Ability to communicate effectively with collaborators and at group/external meetings

Ideal Skills

  • Previous experience in working with murine models
  • Expertise in multi-colour flow cytometry

Other information

The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute. 

Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.

Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:

  • Group Defined Contribution Pension Scheme and Life Assurance
  • Group Income Protection
  • Private Health Insurance
  • 25 days annual leave, increasing by one day a year to a maximum of 30
  • Family friendly environment including options for flexible and part-time working, a childcare voucher scheme, Campus Nursery and Summer holiday club
  • Two days paid Employee Volunteering Leave a year
  • Employee Discount Scheme
  • Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities
  • Active Campus Sports and Social Club
  • Free Campus Bus Service

Genome Research Limited hold an Athena SWAN Bronze Award and will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

Please include a covering letter and CV with your application. Closing date for applications: 6th March 2019