Senior Staff Scientist - Functional Genomics

Salary: £44,159 to £53,432 per annum depending on experience plus excellent benefits.

Permanent position

Applications are invited for a Senior Staff Scientist within the Genomics of Inflammation and Immunity group headed by Dr. Carl Anderson at the Wellcome Sanger Institute (

Our group uses large-scale genetic and genomic data to understand the biological basis of immune-mediated diseases, with a particular focus on inflammatory bowel disease (IBD) and primary sclerosing cholangitis (PSC). We are also interested in how genetic variation shapes the immune-response to challenge.

This Senior Staff Scientist position offers an exciting opportunity to join the leadership team of the group. This permanent position comes with line-management responsibility of a small team of computational staff scientists, and significant mentorship and supervision responsibilities for students and postdocs. You will help maintain the friendly and collegiate atmosphere within the team, which currently consists of geneticists, bioinformaticians, statisticians, immunologists, cell biologistsand clinicians.

We have a number of large-scale molecular QTL mapping studies planned or already underway in the group. You will bring your established expertise in functional genomics and QTL mapping to the group to help lead and deliver these projects. Many of these projects will involve modelling the effect of genetic variation on gene-expression (or other genomic features) over time. In addition, familiarity with the design, analysis and interpretation of single-cell sequence data will be a significant advantage because we are undertaking sc-eQTL mapping studies of intestinal biopsies ascertained from hundreds of IBD patients and healthy controls. You will also help with the interpretation of our large-scale genetic association studies of immune-mediated disease. You will guide the use of in-house and publicly-available functional genomics data to identify the likely effector genes dysregulated by non-coding variants associated immune-mediated diseases.

In addition to taking responsibility for the delivery of our functional genomics projects, you will have significant input into the design of future research projects within the group. The Sanger Institute benefits from world-class data generation pipelines and the significant core funding enables us to rapidly deploy these to answer important biology questions. As such, you will be expected to keep up-to-date with technological advances and consider how these could help the group achieve its high-level research goals.

Job Reference

Essential Skills

  • Ability to work with others in a collegiate and collaborative environment.
  • A PhD in a relevant subject (genetics, functional genomics, computer science, maths)
  • Experience with large-scale computational analysis
  • Statistical/computational genetics skills and an analytical mindset
  • Previous experience with analysis of genotype, sequence or functional genomic data
  • Experience with computer programming & scripting
  • An attention to detail and a drive for rigor
  • Line management potential, with an interest in developing people

Ideal Skills

  • A strong scientific publication record
  • An interest in understanding the biological basis of immune-mediated diseases

Other information

The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute. 

Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.

Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:

  • Defined Contribution Pension Scheme and Life Assurance
  • Group Income Protection
  • Private Health Insurance
  • 25 days annual leave, increasing by one day a year to a maximum of 30
  • Family friendly environment including options for flexible and part-time working, a childcare voucher scheme, Campus Nursery and Summer holiday club
  • Two days paid Employee Volunteering Leave a year
  • Employee Discount Scheme
  • Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities
  • Active Campus Sports and Social Club
  • Free Campus Bus Service

Genome Research Limited hold an Athena SWAN Bronze Award and will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

Please include a CV and a Cover Letter

Closing date: 9th June, however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline.