Senior/ Principal Bioinformatician (Vento-Tormo Team, CellGen)

Salary in the region of £36,737- £53,432- dependent on skills and experience (grade 1 or 2)plus excellent benefits

Permanent/Open contract

The Vento-Tormo lab is seeking a senior/principal bioinformatician (dependant on experience) to work on immunogenomics, developmental transcriptomics and genetics.

Our group aims to understand the influence of cellular micro-environments on defining cellular identities. To perform this research, we make use of state-of-the-art technological advances, such as (but not limited to): single cell transcriptomics and chromatin accessibility sequencing, spatial transcriptomics and whole genome sequencing. We have access to extensive collections of sample repositories through collaboration with local and international groups. We are significant contributors to the Human Cell Atlas and the Human Developmental Cell Atlas projects, an international project to systematically map all cells in the body across the lifespan.

You will be embedded in a multidisciplinary team and lead and coordinate an exciting research project constructing a transcriptomic map of germ cells and gametes across the lifespan. Your primary activities will be to: i) coordinate the project with project partners and team members;  ii) analyse single cell and spatial transcriptomics data to characterise the cell states present in the tissue and their communication at different developmental and adult stages and suggested validation strategies to confirm your findings; iii) support and participate in the development of new computational methods to study cellular communication and gene regulatory networks from single-cell and spatial transcriptomics data. The position would suit a Bioinformatician/Statistician who enjoys developing algorithms and statistical modelling to analyse complex transcriptomics data sets.

For more information on our group visit www.VenToLab.org and the Vento-Tormo group page

Essential Skills

Senior Bioinformatician

  • PhD awarded /in the processes to be awarded in relevant quantitative discipline (e.g. Computational Biology, Genetics, Bioinformatics, Physics, Engineering or Mathematics)
  • Data handling skills
  • Familiarity with Next Generation Sequencing
  • Experience programming in high level scripting languages (preferably R or python)
  • High-impact publications
  • Excellent communication skills to allow efficient interactions with collaborators
  • Experience of writing manuscripts for publication
  • Ability to work within a team
  • Highly developed problem-solving skills

Principal Bioinformatician

  • PhD in relevant quantitative discipline (e.g. Computational Biology, Genetics, Bioinformatics, Physics, Engineering or Mathematics)
  • Demonstrated expertise in the management and analysis of very large data sets
  • Data handling skills
  • Critical and analytic thinking around problems
  • Experience programming in high level scripting languages (preferably R or python)
  • High-impact publications
  • Excellent communication skills, ability to interact across multi-disciplinary team to develop and maintain good working relationship
  • Experience of writing manuscripts for publication
  • Ability to work within a team
  • Highly developed problem-solving skills
  • Ability to anticipate needs and problems while creating solutions
  • Demonstrable good time management and project management skills
  • Attention to detail

 

 

 

Ideal Skills

  • Experience developing statistical methods for the analysis of large data sets, particularly constrained generalised linear models and machine learning methods such as regularised logistic regression, decision trees, or support vector machines
  • Experience with image data analysis

Other information

The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute. 

Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.

Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:

  • Defined Contribution Pension Scheme and Life Assurance
  • Group Income Protection
  • Private Health Insurance
  • 25 days annual leave, increasing by one day a year to a maximum of 30
  • Family friendly environment including options for flexible and part-time working, a childcare voucher scheme, Campus Nursery and Summer holiday club
  • Two days paid Employee Volunteering Leave a year
  • Employee Discount Scheme
  • Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities
  • Active Campus Sports and Social Club
  • Free Campus Bus Service

Genome Research Limited hold an Athena SWAN Bronze Award and will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

Please include a covering letter and CV with your application. Closing date for applications: 27th March 2019