Senior Software Developer - CASM

Salary in the region of £41,259 - £49,922 (dependent on experience) plus excellent benefits

Permanent/ Open Contract

The Opportunity

Highly motivated individual required to join team in the design and development of IT Systems & Workflows for Big Data Genome analysis.

An exciting IT opportunity has become available to further develop our IT systems and analysis workflows in the Cancer, Ageing and Somatic Mutation (CASM) Division. The CASM IT team provide support to scientific staff to help in the Group’s aim of increasing our understanding of cancer and ageing.

Specifically, the role will support the design and development of our compute infrastructure to allow our analysis workflows to be run in a distributed, adaptable and scalable environment. This position would be ideal for someone who enjoys working in a team environment to develop IT solutions for large scale data analysis. These solutions need to be efficient, flexible and under continuous integration to ensure reliability. The design and implementation of the user interfaces to these resources used by the scientific staff need to be intuitive and robust. There are many training opportunities to advance technical skills and personal development.

We are looking for an individual who enjoys working in a supportive multi-disciplinary team environment to help solve complex IT issues which will ultimately aid our understanding of cancer and ageing in humans.

The role can be performed flexibly in line with the Wellcome Sanger Institute’s flexible working arrangements.

The CASM Support IT team has successfully developed a suite of algorithms to analyse genetic variation in cancer genome data. This includes software to detect tumour genetic variation (e.g. single-base substitutions, structural rearrangements, copy number changes) and the ability to annotate the resulting variants and mine the data for interesting patterns and signatures (

The CASM Division has led the way in the systematic analysis of cancer genomes by using the human genome sequence and high throughput mutation detection techniques to identify somatically acquired sequence variants/mutations and hence identify genes critical in the development of human cancers (


Job Reference

Essential Skills

• Good degree in Scientific discipline or Computing 
• Software development skills e.g. Python 
• Keen to learn and share ideas and knowledge 
• Ability to work with scientific staff and translate their requests into reliable and maintainable software 
• Has an eye for detail and takes pride in their work 
• Enjoy working as part of a supportive team 

Ideal Skills

• Ability to work independently, organise own workload and meet deadlines 
• Handling Next Generation sequencing data 
• Experience of using large scale compute farms 
• Developing code in software containers (e.g. Docker) and in cloud environments (e.g. OpenStack) 
• Experience of relational databases 
• Working in an Agile team 

Other information

The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute. 

Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.

Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:

  • Defined Contribution Pension Scheme and Life Assurance
  • Group Income Protection
  • Private Health Insurance
  • 25 days annual leave, increasing by one day a year to a maximum of 30
  • Family friendly environment including options for flexible and part-time working, a childcare voucher scheme, Campus Nursery and Summer holiday club
  • Two days paid Employee Volunteering Leave a year
  • Employee Discount Scheme
  • Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities
  • Active Campus Sports and Social Club
  • Free Campus Bus Service

Genome Research Limited hold an Athena SWAN Bronze Award and will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

Please include a covering letter and CV with your application. Closing date for applications: 11th April 2019