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Postdoctoral Fellow - Lawniczak Group

Salary range: £31,897 to £39,986 depending on experience

Fixed term for 3 years

We are looking for a postdoc interested in using single cell sequencing technologies to investigate natural populations of malaria parasites. This position is funded by an MRC award entitled “Using single-cell RNAseq to investigate human malaria parasite transmission dynamics”

Malaria parasites are single celled organisms, and single cell technologies are revealing new levels of individual variations in lab strains. We have completed the first step in building a “Malaria Cell Atlas” that included single cell RNAseq data from laboratory malaria parasites at various stages in their life cycle (Howick et al 2019 bioRxiv). We will now extend the Malaria Cell Atlas to investigate wild parasites that are likely to exhibit cell-to-cell variation important for pathology and transmission. We will be working closely with African scientists in these efforts and the post will involve spending time in Mali working closely with our collaborators.

We are particularly interested in hearing from applicants who have expertise in working with malaria parasites in the lab or in the field, parasite genomics, and/or single cell or transcriptomic technologies from other organisms. Creativity and initiative are essential and the successful applicant will demonstrate dedication to leading the project while working collaboratively with a range of other scientists. 

We value diversity and we welcome applications from anyone regardless of their gender, age, race, sexual orientation, religion, disability, nationality, or their requirement for part time or flexible working hours due to childcare or other commitments.

Job Reference
83423

Essential Skills

  • PhD in molecular biology, genomics, population genetics or other relevant area of molecular or quantitative analysis
  • Demonstrated analytical and problem solving skills
  • Clear written and oral communication skills 
  • Experience in conducting and trouble shooting complex molecular biology experiments 
  • Excellent organisational and record keeping practise 
  • Knowledge and experience in a relevant field as evidenced by publication record
  • Ability to lead an area of work while working collaboratively
  • Ability to deliver high-quality scientific outputs from complex projects involving multiple partners

Ideal Skills

  • Interest and desire to spend several months per year in Mali 
  • Ability to speak French due to extended periods of time in Mali 
  • Experienceofprocessinglargedatasetsonparallelcomputingclusters
  • Experience of working with malaria parasites 
  • Knowledge of bioinformatic methods for processing next-generation sequencing data, transcriptomic data or similar

Other information

The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute. 

Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity’s greatest challenges.

Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:

  • Defined Contribution Pension Scheme and Life Assurance
  • Group Income Protection
  • Private Health Insurance
  • 25 days annual leave, increasing by one day a year to a maximum of 30
  • Family friendly environment including options for flexible and part-time working, a childcare voucher scheme, Campus Nursery and Summer holiday club
  • Two days paid Employee Volunteering Leave a year
  • Employee Discount Scheme
  • Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities
  • Active Campus Sports and Social Club
  • Free Campus Bus Service

Genome Research Limited hold an Athena SWAN Bronze Award and will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

Please include a covering letter and CV with your application. Closing date for applications: 8th May 2019